Inflammation of adipose tissue (Part 5). The relationship with physiological insulin resistance

Shvarts V.Ia.; Bad Kolberg.

doi:https://doi.org/

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Abstract:

This review contains the results of investigations representing insulin resistance as a physiological factor that ensures supply of macroergic substrates for the functioning organs and tissues. Physical activity promotes the development of insulin resistance in adipose and renal cells with the resulting enhancement of the secretion of glucose and lipids into blood. Simultaneously, the insulin action in muscular cells increases which facilitates utilization of these compounds. The opposite change in insulin sensitivity of different cells is mediated through a rise in interleukin-6 secretion during muscular activity. The immune processes are associated with the development of insulin resistance in adipocytes, hepatocytes, and myocytes leading to the elevation of blood glucose and lipid levels that accounts for the enhanced requirement of immune cells in these compounds. The mechanism underlying the development of insulin resistance during immune processes consists of activation of Toll-like receptors. Increased secretion of placental hormones in the course of gestation causes disturbances in the insulin action in the peripheral tissues and thereby ensures supply of energy-rich and plastic substrates for the growing fetus. Inflammation of adipose tissue is associated with physiological and pathological insulin resistance. This condition is discussed as a factor contributing to the transformation of physiological insulin resistance to pathological one.

Keywords:

adipose tissue

inflammation

adiposity

insulin resistance

physical activity

immune processes gestation

Authors:

Shvarts V.Ia.

Reabilitatsionnaia klinika Bad Kolberg, Germaniia

Bad Kolberg.

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References:

Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006; 7: 85-96.
Thirone A.C., Huang C., Klip A. Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol Metab 2006; 17: 72-78.
Duncan R.E., Ahmadian M., Jaworski K., Sarkadi-Nagy E., Sul H.S. Regulation of lipolysis in adipocytes. Ann Rev Nutr 2007; 27: 79-101.
Gual P., Le Marchand-Brustel Y., Tanti J.F. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005; 87: 99-109.
Shvarts V. Vospalenie zhirovoi tkani (chast' 2). Patogeneticheskaya rol' pri sakharnom diabete 2-go tipa. Probl endokrinol 2009; 5: 43-48.
Dongsheng G., Minsheng Y., Frantz D.F. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-Β and NF-χB. Nature Med 2006; 11: 2: 183-190.
Friedman J.E., Ishizuka T., Shao J., Huston L., Highman T., Catalano P. Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes. Diabetes 1999; 48: 1807-1814.
Saad M.J., Maeda L., Brenelli S.L., Carvalho C.R., Paiva R.S., Velloso L.A. Defects in insulin signal transduction in liver and muscle of pregnant rats. Diabetologia 1997; 40: 179-186.
Yamada K., Yamakawa K., Terada Y., Kawaguchi K., Sugaya A., Sugiyama T., Toyoda N. Expression of GLUT4 glucose transporter protein in adipose tissue and skeletal muscle from streptozotocin-induced diabetic pregnant rats. Horm Metab Res 1999; 31: 508-513.
Connolly C.C., Papa T., Smith M.S. et al. Hepatic and muscle insulin action during late pregnancy in the dog. Regulatory, integrative and comparative physiology. Am J Physiol 2008; 292: 1: R447-R452.
Polderman K.H., Gooren L.J., Asscheman H., Bakker A., Heine R.J. Induction of insulin resistance by androgens and estrogens. J Clin Endocrinol Metab 1994; 79: 265-271.
Weigert C., Schleicher E.D. Interleukin-6 - Freund oder Feind für den Diabetiker? Diabetes Stoffwechsel 2005; 14: 141-149.
Winnick J.J., Sherman W.M., Habash D.L. et al. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepstic insulin sensitivity. J Clin Endocrinol Metab 2008; 93: 771-778.
Shvarts V. Regulyatsiya metabolicheskikh protsessov interleikinom-6. Tsitokiny i vospalenie 2009; 3: 3-10.
Febbraio M.A., Pedersen B.K. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 2002; 16: 1335-1347.
Pedersen B.K. IL-6 signaling in exercise and disease. Biochem Soc Trans 2007; 35: 1295-1297.
Febbraio M.A., Hiscock N., Sacchetti M. et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 2004; 53: 1643-1648.
Penkowa M., Keller C., Keller P. et al. Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise. FASEB J 2003; 17: 2166-2168.
Ostrowski K., Rohde T., Asp S. et al. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol 1999; 515: Pt 1: 287-291.
Desruisseaux M.S., Nagajyothi, Trujillo M.E. et al. Adipocyte, Adipose Tissue, and Infectious Disease. Infect Immun 2007; 75: 1066-1078.
Lanza-Jacoby S., Tabares A. Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats. Am J Physiol 1990; 258: E678-E685.
Esteve E., Ricart W., Fernandez-Real J.M. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr 2005; 24: 16-31.
Khovidhunkit W., Kim M.S., Memon R.A. et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanism and consequence to the host. J Lipid Res 2004; 45: 1169-1196.
Wolowczuk I., Verwaerde C., Viltart O. et al. Feeding Our Immune System: Impact on Metabolism. Clin Dev Immunol 2008; 2008: 639-803.
Ciofani M., Zúñiga-Pflücker J.C. Notch promotes survival of pre-T cells at the Β-selection checkpoint by regulating cellular metabolism. Nature Immunology 2005; 6: 9: 881-888.
Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294: 5548: 1871-1875.
Schaeffler A., Schoelmerich J., Bruchler C. Mechanisms of disease: adipocytokines and visceral adipose tissue-emerging role in intestinal and mesenteric diseases. Nature Clin Pract Gastroenterol Hepatol 2005; 2: 2: 103-111.
Zauner A., Nimmerrichter P., Anderwald C. et al. Severity of insulin in critically ill medical patients. Metabolism 2006; 56: 1-5.
Brikos C., ONeill L.A. Signaling of toll-like receptors. Handb Exp Pharmacol 2008; 183: 21-50.
Suganami T., Tanimoto-Koyama K., Nishida J. et al. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 2007; 27: 84-91.
Shi H., Kokoeva M.V., Inouye K., Tzameli I., Yin H., Flier J.S. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Inv 2006; 116: 3015-3025.
Radin M.S., Sinha S., Bhatt B.A. et al. Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle. Diabetologia 2008; 51: 336-346.
Lee J.Y., Hwang D.H. The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Molecul Cells 2006; 21: 2: 174-185.
Schaeffler A., Gross P., Buettner R. et al. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology 2009; 126: 233-245.
Shvarts V. Vospalenie zhirovoi tkani (chast' 4). Ozhirenie - novoe infektsionnoe zabolevanie? Probl endokrinol 2010; 5.
Wilson P.W., Umpierrez G.E. Insulin resistance and pubertal changes. J Clin Endocrinol Metab 2008; 93: 7: 2472-2473.
Dulloo A.G. Regulation of fat storage via suppressed thermogenesis: a thrifty rhenotype that predisposes individuals with catch-up growth to insulin resistance and obesity. Horm Res 2006; 65: 90-97.
Erol A. Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress. Bioessays 2007; 29: 811-818.
Fridlyand L.E., Philipson L.H. Reactive species and early manifestation of insulin resistance in type 2 diabetes. Diabetes Obes Metab 2006; 8: 136-145.
Moorad J.A., Hall D.W. Age-dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy. J Evol Biol 2009; 125: 38-49.
Nunn A.V.W., Bell J.D., Guy G.W. Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nutrit Metab 2009; 6: 16-29.