Oxidative stress in type 2 diabetes mellitus and methods for its correction

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Recent publications concerning mechanisms of late vascular complications of type 2 diabetes mellitus lay emphasis on oxidative stress as a major factor contributing to their development. Moreover, oxidative stress induced by hyperglycemia is considered to be the main cause underlying beta-cell lesion that accelerates progression of diabetes. Modern hypoglycemic agents must have additional properties preventing the development of vascular complications. Gliclazide MV is considered to be a medicine displaying anti-atherogenic and anti-oxidative properties that promote the survival of beta-cells exposed to oxidative stress and increase the resistance of low-density lipoproteins to oxidation.

Keywords:

type 2 diabetes mellitus

oxidative stress

active oxygen species

gliclazide MV

Authors:

Ametov A.S.

Federal'noe agentstvo po zdravookhraneniiu i sotsial'nomu razvitiiu;
GOU DPO Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Solov'eva O.L.

GOU DPO Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

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