Alterations of the thyroid structure and function in experimental hypopinealism

Bondarenko L.A.; Sergienko L.Iu.; Sotnik N.N.; Cherevko A.N.

doi:https://doi.org/

Bondarenko L.A.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Sergienko L.Iu.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Sotnik N.N.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Cherevko A.N.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Alterations of the thyroid structure and function in experimental hypopinealism

Authors:

Bondarenko L.A., Sergienko L.Iu., Sotnik N.N., Cherevko A.N.

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Journal: Problems of Endocrinology. 2011;57(2): 32‑35

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Bondarenko LA, Sergienko LIu, Sotnik NN, Cherevko AN. Alterations of the thyroid structure and function in experimental hypopinealism. Problems of Endocrinology. 2011;57(2):32‑35. (In Russ.)

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Abstract:

The pituitary-thyroid axis of young sexually mature rabbits kept under a 24-hour daylight photoperiod was shown to undergo phase-modulated variations of hormonal activity with its initial increase (during the first month) and subsequent progressive decrease (within 2-5 months after the onset of exposure to light). These changes correlated with the time-dependent fall in the blood T3, T4, and TSH levels. Simultaneously, the animals developed pathological changes in the histological structure of the thyroid gland similar to those in patients with secondary or tertiary hypothyroidism. It is concluded that hormonal and structural changes in the thyroid gland during long-term hypopinealism should be regarded as an experimental model of hypothyroidism of neuroendocrine origin.

Keywords:

hypopinealism

melatonin

thyroid gland

24-hour light photoperiod

Authors:

Bondarenko L.A.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Sergienko L.Iu.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Sotnik N.N.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

Cherevko A.N.

Institut problem éndokrinnoĭ patologii im. V.Ia. Danilevskogo AMN Ukrainy, Khar'kov, Ukraina

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