Objective. To determine biological correlations between tissue oxygen pressure and skin blood flow with changes in free-radical processes in people of different age groups. Material and methods. The study included 153 healthy women (84%) and men (16%) of different age groups and degree of skin aging. Clinical examination was associated with instrumental survey (oximetry and flowmetry at different points of the neck and face). Laboratory examination included analysis of serum reactive oxygen forms, antioxidant activity and malonedialdehyde as a marker of cellular destruction. Results. The level of reactive oxygen forms directly correlated with age of people. Concentration of active oxygen forms was more than 5 times higher in advanced age group compared with than younger people. The revealed changes directly correlated with age-related skin aging and inversely correlated with microcirculation (r= –0.419; p<0.05). In young people (25—30 years old), capillary blood flow rates were 26% higher and skin oxygen pressure 60% higher compared with older people. Serum indices of lipid peroxidation were constant in healthy persons. Conclusion. We confirmed reduced capillary blood flow in skin that is associated with reduced cellular metabolic processes. Age-related aggravation of tissue hypoxia is followed by growth of active oxygen forms. These changes result skin aging. Considering stable indices of lipid peroxidation in people of various age, we can assume that increased level of active oxygen forms in mitochondria is a consequence of tissue blood flow disturbances rather primary cause of these disorders. Thus, progressive decrease of blood circulation in the skin followed by systemic increase of reactive oxygen forms justifies an expediency of application of the procedures or drugs for elimination of skin aging signs. These measures facilitate blood flow recovery and conversion of anaerobic glycolysis into aerobic one. Thus, energy release is increased by 19 times. As a result, treatment outcomes in plastic surgery and cosmetology may be improved.