Objective. Lifetime study of the anatomical structure of the soleal veins using multislice computed tomography venography. Subjects and methods. In the period of 2015—2018, a total of 400 people of both sexes with chronic venous diseases were examined using the developed procedure for multislice CT venography. According to the international CEAP classification, the patients were allocated into: C0 (n=50 (12.5%)); C1 (n=58 (16.5%)); C2—C3 (n=173 (49.5%)), and 119 (34%) people had trophic disorders (C4—C6). Examinations were performed using a Philips Ingenuity 128-slice multislice CT scanner (the Netherlands) with the IntelliSpace Portal Image Editing Software package (the Netherlands), followed by 3D image reconstruction. Results. The 400 extremities examined were found to have 8.510 soleal veins that were represented by single, paired, V- and Y-shaped trunks, with 82% of the cases being mixed. Analysis of the findings allowed identification of first-order great veins, second-order axial veins, and third-order terminal veins (73, 83, and 73%, respectively). The great, network, and mixed types of development of the venous tubing line were identified according to the division of the great and axial veins and the extent of terminal veins. The valvular apparatus was detected at the level of the first-order great veins in 100% of cases and at the level of the second-order veins in 65%. The valvular apparatus was poorly visualized in the third-order terminal veins. There were vast majority of communication connections of the soleal veins with saphenous tubing lines on the medial and posteromedial surfaces of the leg via the perforating veins located there: with the oblique, intersaphenous, and posterior arch veins in 48, 23, and 57% of cases, respectively; i.e. these belonged to the retro-tibial perforators (Cockett’s group). The soleal veins had a cylindrical shape in 35.9% of cases and fusiform ectasia of different length was present in 64.1%. Conclusion. The lifetime features of the anatomical structure of the soleal veins, which are established by multislice CT venography, will assist vascular surgeons, phlebologists, radiologists, and ultrasound diagnosticians in interpreting the findings. The established fact that there is variability in the shape of the soleal veins with the development of their ectasia in patients with varicose disease may suggest that these veins are involved in the formation of anomalous segmental hypervolemia of the leg when chronic venous insufficiency develops and progresses.