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Kit O.I.

Rostov Research Institute of Oncology, Rostov-na-Donu, Russia

Frantsiyants E.M.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Bandovkina V.A.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Cheryarina N.D.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Aleinov V.I.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Shalashnaya E.V.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

The content of steroid hormones, their precursors and ACTH in the blood of patients with pathology of pancreas

Authors:

Kit O.I., Frantsiyants E.M., Bandovkina V.A., Cheryarina N.D., Aleinov V.I., Shalashnaya E.V.

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Journal: P.A. Herzen Journal of Oncology. 2020;9(3): 29‑33

DOI: 10.17116/onkolog2020903129

Read: 7579 times

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THE CONTENT OF STEROID HORMONES, THEIR PRECURSORS AND ACTH IN THE BLOOD OF PATIENTS WITH PATHOLOGY OF PANCREAS
THE CONTENT OF STEROID HORMONES, THEIR PRECURSORS AND ACTH IN THE BLOOD OF PATIENTS WITH PATHOLOGY OF PANCREAS

To cite this article:

Kit OI, Frantsiyants EM, Bandovkina VA, Cheryarina ND, Aleinov VI, Shalashnaya EV. The content of steroid hormones, their precursors and ACTH in the blood of patients with pathology of pancreas. P.A. Herzen Journal of Oncology. 2020;9(3):29‑33. (In Russ.)
https://doi.org/10.17116/onkolog2020903129

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Introduction. The relationship of pancreatic pathology with sex steroids has only indirect confirmation. Aim of study — to study the content of steroid hormones and ACTH in the blood of patients with pancreatic diseases. In the blood of 51 men with pancreatic pathology, the standard RIA methods were used to determine the level of steroid sex hormones, cortisol and ACTH. In patients with chronic pancreatitis, an increase in the level of testosterone and cortisol was revealed in the blood, patients with pancreatic cancer showed a decrease in the level of DHEA-S and 17ONP. The presence of the neuroendocrine component exacerbated the decrease of the precursors of steroid DHEA-S and 17OHP, which affected the drop of testosterone and estradiol levels in blood. Only in patients with adenocarcinoma, regardless of the presence of the neuroendocrine component, a high level of ACTH was revealed. Chronic pancreatitis and pancreatic cancer are accompanied by an increase in the ratio of cortisol/DHEA-S in the blood, which indicates a decrease in the adaptive capacity of the body. It was only for pancreatic malignant tumors that a decrease in blood levels of the precursors of synthesis of sex steroids DHEA-S and 17OHP was found to be characteristic.

Keywords:

pancreas
adenocarcinoma
neuroendocrine cancer
steroid hormones
cortisol
ACTH

Authors:

Kit O.I.

Rostov Research Institute of Oncology, Rostov-na-Donu, Russia

Frantsiyants E.M.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Bandovkina V.A.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Cheryarina N.D.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Aleinov V.I.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

Shalashnaya E.V.

Rostov Cancer Research Institute, Rostov-on-Don, Russia

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References:

  1. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22(44):9694-9705. https://doi.org/10.3748/wjg.v22.i44.9694
  2. Paternoster S, Falasca M. The intricate relationship between diabetes, obesity and pancreatic cancer. Biochim Biophys Acta Rev Cancer. 2019;1873(1):188326. https://doi.org/10.1016/j.bbcan.2019.188326
  3. Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA, Del Río Hernández AE. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. 2019;20(1). pii: e46556. https://doi.org/10.15252/embr.201846556
  4. Satake M, Sawai H, Go VLW, Satake K, Reber HA, Hines OJ, Eibl G. Estrogen receptors in pancreatic tumors. Pancreas. 2006;33(2):119-127. https://doi.org/10.1097/01.mpa.0000226893.09194.ec
  5. Georgiadou D, Sergentanis TN, Sakellariou S, Vlachodimitropoulos D, Psaltopoulou T, Lazaris AC, Gounaris A, Zografos GC. Prognostic role of sex steroid receptors in pancreatic adenocarcinoma. Pathol Res Pract. 2016;212(1):38-43. https://doi.org/10.1016/j.prp.2015.11.007
  6. Masoudi S, Momayez Sanat Z, Mahmud Saleh A, Nozari N, Ghamarzad N, Pourshams A. Menstrual and reproductive factors and risk of pancreatic cancer in women. Middle East J Dig Dis. 2017;9(3):146-149. https://doi.org/10.15171/mejdd.2017.65
  7. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):359-386. https://doi.org/10.1002/ijc.29210
  8. Tang LH, Basturk O, Sue JJ, Klimstra DS. A practical approach to the classification of WHO grade 3 (G3) well-differentiated neuroendocrine tumor (WD-NET) and poorly differentiated neuroendocrine carcinoma (PD-NEC) of the pancreas. Am J Surg Pathol. 2016;40(9):1192-1202. https://doi.org/10.1097/PAS.0000000000000662
  9. Patel N, Barbieri A, Gibson J. Neuroendocrine tumors of the gastrointestinal tract and pancreas. Surg Pathol Clin. 2019;12(4):1021-1044. https://doi.org/10.1016/j.path.2019.08.007
  10. Perez K, Chan J. Treatment of gastroenteropancreatic neuroendocrine tumors. Surg Pathol Clin. 2019;12(4):1045-1053. https://doi.org/10.1016/j.path.2019.08.011
  11. Stevens KJ, Lisanti C. Pancreas imaging. StatPearls [Internet]. Treasure Island (FL): StatPearls Publ.; 2019. Available at: http://creativecommons.org/licenses/by/4.0/
  12. Sollie S, Michaud DS, Sarker D, Karagiannis SN, Josephs DH, Hammar N, Santaolalla A, Walldius G, Garmo H, Holmberg L, Jungner I, Van Hemelrijck M. Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study. BMC Cancer. 2019;19(1):858. https://doi.org/10.1186/s12885-019-6082-6
  13. Lew D, Afghani E, Pandol S. Chronic pancreatitis: current status and challenges for prevention and treatment. Dig Dis Sci. 2017;62(7):1702-1712. https://doi.org/10.1007/s10620-017-4602-2
  14. Yanagita I, Fujihara Y, Kitajima Y, Tajima M, Honda M, Kawajiri T, Eda T, Yonemura K, et al. A high serum Cortisol/DHEA-S ratio is a risk factor for sarcopenia in elderly diabetic patients. J Endocr Soc. 2019;3(4):801-813. https://doi.org/10.1210/js.2018-00271
  15. deLignières B. Androgen replacement therapies for postmenopausal women. In: Erkkola R., ed. The menopause. Philadelphia, PA: Elsevier; 2006.
  16. Kanda N, Hoashi T, Saeki H. The roles of sex hormones in the course of atopic dermatitis. Int J Mol Sci. 2019;20(19). pii: E4660. https://doi.org/10.3390/ijms20194660
  17. Cho S, Park WJ, Kang W, Lim HM, Ahn JS, Lim DY, Moon JD. The association between serum dehydroepiandrosterone sulfate (DHEAS) levels and job-related stress among female nurses. Ann Occup Environ Med. 2019;31:18. https://doi.org/10.35371/aoem.2019.31.e18
  18. Lai HM, Liu MS, Lin TJ, Tsai YL, Chien EJ. Higher DHEAS levels associated with long-term practicing of Tai Chi. Chin J Physiol. 2017;60(2):124-130. https://doi.org/10.4077/CJP.2017.BAF454
  19. Aoki K, Terauchi Y. Effect of dehydroepiandrosterone (DHEA) on diabetes mellitus and obesity. Vitam Horm. 2018;108:355-365. https://doi.org/10.1016/bs.vh.2018.01.008
  20. Yehuda R, Flory JD, Southwick S, Charney DS. Developing an agenda for translational studies of resilience and vulnerability following trauma exposure. Ann N Y Acad Sci. 2006;1071(1):379-396. https://doi.org/10.1196/annals.1364.028
  21. Will A, Wynne-Edwards K, Zhou R, Kitaysky A. Of 11 candidate steroids, corticosterone concentration standardized for mass is the most reliable steroid biomarker of nutritional stress across different feather types. Ecol Evol. 2019;9(20):11930-11943. https://doi.org/10.1002/ece3.5701
  22. Basaki M, Saeb M, Saeb S. Androgen profile in young females with insulin resistance; the importance of 17-HydroxyprogesteroneAndrogens in young insulin resistant females. Gynecol Endocrinol. 2019;35(12):1094-1098. https://doi.org/10.1080/09513590.2019.1630377
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