The objective of the study was to assess the impact on the efficacy of the treatment of colorectal cancer included in the scheme of drug therapy Remaxol. The analysis of the data of 145 patients with colorectal cancer metastases T4 and without. Chemotherapy was conducted in two schemes: FOLFOX - in 51 patients in the first group and 34 - of the second and FOLFIRI - in 32 and 28 patients respectively. Repeated courses of 2 weeks. In both schemes conducted from 6 to 12 courses. Patients without liver metastasis in the first stage of the treatment received surgery in the presence of metastasis - the operation is not carried out. The study group included 83 patients who received the drug Remaxol - intravenously, slowly, 400 ml, 1 time per day, for the introduction of 4 after each course of chemotherapy. In the control group 62 patients received standard therapy support. The patients were examined according to the accepted standards, in addition to observing the dynamics of the investigated parameters of hepatic activity and quality of life. It was found that the effectiveness of treatment of patients with colorectal cancer metastases T 4 and free for inclusion in the scheme of the drug remaxol increased by reducing the liver toxicity of chemotherapy conducted manifested faster and more pronounced cupping indicators of hepatic activity. Improving the quality of life of patients by improving the performance of physical, mental and social activity to a greater extent - in patients who have undergone organ-operation. The results allow us to offer turn Remaxol as a preparation accompanying therapy during chemotherapy in patients with colorectal cancer.