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Stefan Pilz
Medical University of Graz
Armin Zittermann
Clinic for Thoracic and Cardiovascular Surgery NRW
Christian Trummer
Medical University of Graz
Verena Theiler-Schwetz
Medical University of Graz
Elisabeth Lerchbaum
Medical University of Graz
Keppel Martin H.
University Institute for Medical and Chemical Laboratory Diagnostics
Grübler Martin R.
University of Bern
Winfried März
Medical University of Graz;
Ruperto-Carola University of Heidelberg;
Synlab Medical Center of Human Genetics Mannheim
Marlene Pandis
Medical University of Graz
Vitamin D testing and treatment: a narrative review of current evidence
Journal: Laboratory Service. 2021;10(2): 55‑72
Views: 7422
Downloaded: 152
To cite this article:
Stefan Pilz, Armin Zittermann, Christian Trummer, et al. . Vitamin D testing and treatment: a narrative review of current evidence. Laboratory Service.
2021;10(2):55‑72. (In Russ.)
https://doi.org/10.17116/labs20211002155
Vitamin D testing and treatment is a subject of controversial scienti c Discussions, and it is challenging to navigate through the expanding vitamin D literature with heterogeneous and partially opposed opinions and recommendations. In this narrative review, we aim to provide an update on vitamin D guidelines and the current evidence on the role of vitamin D for human health with its subsequent implications for patient care and public health issues. Vitamin D is critical for bone and mineral metabolism, and it is established that vitamin D De ciency can cause rickets and osteomalacia. While many guidelines recommend target serum 25-hydroxyvitamin D (25[OH]D) concentrations of ≥50 nmol/L (20 ng/mL), the minimum consensus in the scienti c community is that serum 25(OH)D concentrations below 25—30 nmol/L [10—12 ng/mL) must be prevented and treated. Using this latter threshold of serum 25(OH)D concentrations, it has been Documented that there is a high worldwide prevalence of vitamin D De ciency that may require public health actions such as vitamin D food forti cation. On the other hand, there is also reason for concern that an exploding rate of vitamin D testing and supplementation increases costs and might potentially be harmful. In the scienti c Debate on vitamin D, we should consider that nutrient trials Di er from Drug trials and that apart from the opposed positions regarding indications for vitamin D treatment we still have to better characterize the precise role of vitamin D for human health.
Authors:
Stefan Pilz
Medical University of Graz
Armin Zittermann
Clinic for Thoracic and Cardiovascular Surgery NRW
Christian Trummer
Medical University of Graz
Verena Theiler-Schwetz
Medical University of Graz
Elisabeth Lerchbaum
Medical University of Graz
Keppel Martin H.
University Institute for Medical and Chemical Laboratory Diagnostics
Grübler Martin R.
University of Bern
Winfried März
Medical University of Graz;
Ruperto-Carola University of Heidelberg;
Synlab Medical Center of Human Genetics Mannheim
Marlene Pandis
Medical University of Graz
Received:
20.04.2021
Accepted:
02.05.2021
List of references:
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