Systemic bias in randomized clinical trials in different fields of medicine in 2014

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OBJECTIVE

To analyze the causes of systemic bias in modern randomized trials potentially distorting the results in relation to real clinical practice.

MATERIAL AND METHODS

The Rob2 tool presented in the Cochrane Handbook for Systematic Reviews of Interventions guidelines was used to assess the risk. Among 2.555 studies, we enrolled 25 ones into this review. For examples of each type of systemic bias, we selected one article related to each of the five topics: oncology, cardiology, endocrinology, COVID-19, biological drugs for various diseases (therapy, infectious diseases).

RESULTS

We established the main critical area of clinical trials where systemic bias leads to incomparability of populations of clinical trial subjects and patients in real practice.

CONCLUSION

Only pooling the results of clinical trials and real practice will allow a significant assessment of data.

Keywords:

evidence-based medicine

randomized clinical trials

systemic bias

real clinical practice

Authors:

Lantsova E.V.

Sciencefiles LLC

ORCID: 0000-0002-1412-0711

Smirnova N.G.

Sciencefiles LLC

ORCID: 0009-0008-0075-9638

Lebedinskii K.M.

Mechnikov North-West State Medical University

SPIN RSCI: 3590-2308
Scopus AuthorID: 6602775085
ResearcherID: O-8655-2014
ORCID: 0000-0002-5752-4812

Received:

07.06.2024

Accepted:

17.07.2024

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