Систематические ошибки рандомизированных клинических исследований в различных областях медицины, проведенных в 2014

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ЦЕЛЬ ИССЛЕДОВАНИЯ

Выполнить анализ источников рисков систематической ошибки в современных рандомизированных исследованиях, наличие которой может привести к искажению результатов по отношению к реальной клинической практике.

МАТЕРИАЛ И МЕТОДЫ

Для оценки риска применяли инструмент Rob2, представленный в рекомендациях Cochrane Handbook for Systematic Reviews of Interventions. Из найденных 2555 исследований в обзор включено 25. Для примеров каждого вида систематической ошибки выбрано по одной статье, относящейся к каждой из пяти выбранных тем: онкология, кардиология, эндокринология, COVID-19, применение биологических препаратов при различных заболеваниях (терапия, инфекционные болезни).

РЕЗУЛЬТАТЫ

Выявлена основная критическая зона клинических исследований, в которой наличие систематической ошибки приводит к несопоставимости популяций субъектов клинических исследований и пациентов реальной практики.

ЗАКЛЮЧЕНИЕ

Показано, что только объединение результатов клинических исследований и реальной практики позволит провести достоверную оценку полученных данных.

Ключевые слова:

доказательная медицина

рандомизированные клинические исследования

систематическая ошибка

реальная клиническая практика

Авторы:

Ланцова Е.В.

ООО «Сайнсфайлз»

ORCID: 0000-0002-1412-0711

Смирнова Н.Г.

ООО «Сайнсфайлз»

ORCID: 0009-0008-0075-9638

Лебединский К.М.

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России

SPIN РИНЦ: 3590-2308
Scopus AuthorID: 6602775085
ResearcherID: O-8655-2014
ORCID: 0000-0002-5752-4812

Дата поступления:

07.06.2024

Дата принятия в печать:

17.07.2024

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