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Kochetov A.G.

Tsentr kardiokhirurgii i tsentr urologii 3-go Tsentral'nogo voennogo klinicheskogo gospitalia im. A.A. Vishnevskogo MO RF, Moskovskaia oblast', Krasnogorsk

Lyang O.V.

Assotsiatsija spetsialistov i organizatsij laboratornoj sluzhby «Federatsija laboratornoj meditsiny», 127083 Moskva, ul. 8 Marta, 1, str.12

Gimadiev R.R.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare of the Russian Federation

Abramov A.A.

National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation

Zhirov I.V.

National medical research center of cardiology MH RF

Skvortsov A.A.

Federal State Budget Organization National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation, Moscow, Russia

Zaseeva A.V.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare of the Russian Federation

Bosykh E.G.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare of the Russian Federation

Masenko V.P.

National Medical Research Center of Cardiology, Ministry of Healthcare of Russia

Tereshchenko S.N.

National medical research center of cardiology MH RF

Expression of circulating microRNA in chronic heart failure in patients with cardiovascular pathologies

Authors:

Kochetov A.G., Lyang O.V., Gimadiev R.R., Abramov A.A., Zhirov I.V., Skvortsov A.A., Zaseeva A.V., Bosykh E.G., Masenko V.P., Tereshchenko S.N.

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Journal: Laboratory Service. 2016;5(1): 26‑32

DOI: 10.17116/labs20165126-32

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Table of contents

EXPRESSION OF CIRCULATING MICRORNA IN CHRONIC HEART FAILURE IN PATIENTS WITH CARDIOVASCULAR PATHOLOGIES
EXPRESSION OF CIRCULATING MICRORNA IN CHRONIC HEART FAILURE IN PATIENTS WITH CARDIOVASCULAR PATHOLOGIES

To cite this article:

Kochetov AG, Lyang OV, Gimadiev RR, et al. . Expression of circulating microRNA in chronic heart failure in patients with cardiovascular pathologies. Laboratory Service. 2016;5(1):26‑32. (In Russ.)
https://doi.org/10.17116/labs20165126-32

Подписка 2025 Лабораторная служба (Laboratory Service)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Recent experimental and clinical studies in chronic heart failure (CHF) pointed on the dysregulation of circulating microRNA expression. The goal of this research was to evaluate diagnostic potential of microRNA in plasma of patients with CHF. Materials and methods. The level of circulating microRNA (21, 423-5р, 208а, 499а and 34а) were tested in plasma of 56 patients with CHF and 15 patients with cardiovascular pathologies without evidence of CHF (control group) using RT-PCR. Results. Biomarkers for the principal causes of CHF were found: dilatational cardiomyopathy (DCMP) and inflammatory cardiomyopathy (ICMP). It was shown that the level of microRNA-34a in patients with CHF caused by uncompensated hypertonic heart was 20.8 times lower in comparison with the control group (p=0.009). The level of microRNA-21 was 1.7 times higher in patients with CHF (p=0.022) and can be used as a biomarker for CHF (AUC 0.694 (CI =95% 0.550—0.838), threshold value 882.9 i.u., sensitivity and specificity — 52% and 87% respectively). Besides this, an inverse correlation was found between the level of microRNA-21 and stages of CHF according to Vasilenko VH and Starzhesko ND classification (r=–0.304, р=0.036). Plasma levels of microRNA-21 and microRNA-423-5p were 4.4 and 11.3 times higher in patients with ICMP, respectively. Plasma level of microRNA-21 in patients with DCMP was 1.7 times higher than in control group. Conclusion. We were able to show that plasma levels of microRNA-21 can be used as biomarkers of CHF, ICMP and DCMP; and plasma level of microRNA-423-5p can be used as biomarker of ICMP.

Keywords:

chronic heart failure
inflammatory cardiomyopathy
dilatational cardiomyopathy
microRNA

Authors:

Kochetov A.G.

Tsentr kardiokhirurgii i tsentr urologii 3-go Tsentral'nogo voennogo klinicheskogo gospitalia im. A.A. Vishnevskogo MO RF, Moskovskaia oblast', Krasnogorsk

Lyang O.V.

Assotsiatsija spetsialistov i organizatsij laboratornoj sluzhby «Federatsija laboratornoj meditsiny», 127083 Moskva, ul. 8 Marta, 1, str.12

Gimadiev R.R.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare of the Russian Federation

Abramov A.A.

National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation

Zhirov I.V.

National medical research center of cardiology MH RF

Skvortsov A.A.

Federal State Budget Organization National Medical Research Center of Cardiology, Ministry of Healthcare Russian Federation, Moscow, Russia

Zaseeva A.V.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare of the Russian Federation

Bosykh E.G.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare of the Russian Federation

Masenko V.P.

National Medical Research Center of Cardiology, Ministry of Healthcare of Russia

Tereshchenko S.N.

National medical research center of cardiology MH RF

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References:

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