Autologous plasma enriched with platelet cells (Platelet Rich Plasma, PRP) is a promising treatment agent in regenerative medicine as far as it is a source of cytokines, growth factors and other biologically active substances. This technique is increasingly used in various areas of medicine, including aesthetic medicine. The use of autologous drugs has a number of advantages, including low risk of immunological responses, safety, good tolerance with minimal side effects. Plasma therapy for some inflammatory diseases (acne, rosacea, seborrhea) is recommended in comprehensive therapy of skin pathology. Patient D., 31 years old, complaining of increased skin oiliness, rashes on the facial skin was under our supervision. Acne vulgaris diagnosis was made based on the patient’s complaints, medical history’s data and clinical laboratory results. A comprehensive therapy with systemic isotretinoin, phototherapy and the autologous plasma administration was prescribed. We have convincingly demonstrated that comprehensive acne therapy with systemic isotretinoin, phototherapy and PRP provide synergistic effect, which allows to achieve regression of the disease’s clinical manifestations, reduce its duration and decrease the drug load on the patient’s body in the absence of side effects.