The role of photoprotection in light-sensitive dermatoses

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It is known that UV-radiation significantly affects skin, causes premature aging, pigmentation and other changes. Sunscreens with UV-filters that mainly block UVA- and UVB-radiation are used as protection against UV-radiation. Sun protection is particularly important in a number of photosensitive dermatoses. One of such diseases is rosacea. UV-radiation exposure increases risks of rosacea development, in addition, UVB has angiogenic properties that contribute to telangiectasia occurrence. Another condition caused by negative effect of UV-radiation is cutaneous lupus erythematosus. Adaptive immune system is activated under the ultraviolet action, autoantibodies are produced that leads to further dermatosis development. It has also been shown that UV-radiation can increase apoptosis. Chloasma, which is most common in pregnant women, should be noted among pigment disorders caused by sunlight. The use of photoprotective agents comes to the first place due to the impossibility of applying certain therapies in this group. Recently, the effect of visible light, particularly blue light (400—500 nm), on the skin has been actively studying. It has been shown that visible light causes more pronounced pigmentary changes in chloasma. The light in blue spectrum can penetrate deeper into the dermis and cause more serious damages than UV-light. Additionally, an increase of the expression of a number of proinflammatory cytokines under the impact of waves of this length is noted, which may play an important role in some chronic dermatoses. That is why it is important to use photoprotective agents which can protect the skin not only from ultraviolet radiation, but also from blue light.

Keywords:

rosacea

lupus erythematosus

chloasma

photoprotective agents

Authors:

Sakaniya L.R.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Center for Theoretical Problems of Physicochemical Pharmacology Institution of Russian Academy of Sciences

ORCID: 0000-0003-2027-5987

Mikheeva E.S.

Peoples’ Friendship University of Russia

ORCID: 0000-0001-8934-3197

Tserikidze N.G.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0003-2758-4002

Korsunskaya I.M.

Center for Theoretical Problems of Physicochemical Pharmacology Institution of Russian Academy of Sciences

ORCID: 0000-0002-6583-0318

Received:

09.04.2024

Accepted:

23.04.2024

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