The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Tereshchenko G.P.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

Gadzhigoroeva A.G.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

Golousenko I.Yu.

Russian University of Medicine

Clinical and epidemiological features of atopic type of alopecia areata

Authors:

Tereshchenko G.P., Potekaev N.N., Gadzhigoroeva A.G., Zhukova O.V., Golousenko I.Yu.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(2): 155‑160

DOI: 10.17116/klinderma202423021155

Views: 439

Downloaded: 5

Buy for 200₽
Contact the author
Table of contents

To cite this article:

Tereshchenko GP, Potekaev NN, Gadzhigoroeva AG, Zhukova OV, Golousenko IYu. Clinical and epidemiological features of atopic type of alopecia areata. Russian Journal of Clinical Dermatology and Venereology. 2024;23(2):155‑160. (In Russ.)
https://doi.org/10.17116/klinderma202423021155

Подписка 2025 (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Mediasphera_Net
Close metadata
Recommended articles:
Como­rbidity patterns and stru­cture of depressive episodes in patients with bipo­lar diso­rder and major depressive diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(11-2):108-114
Orga­nic mental diso­rders with como­rbid alco­holism in the elde­rly. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;(12):27-33
Mental diso­rders, social and demo­graphic characteristics of patients with chro­nic and episodic migraine. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(1):94-101
Alexithymia and self-harm in people with borderline personality diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(1):102-108
Pecu­liarities of the dyna­mics of eating diso­rders in the stru­cture of depressive states. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(1):109-113
Multimorbidity in asthma. Russian Journal of Preventive Medi­cine. 2024;(1):84-89
Features of cognitive impairment in bipo­lar affe­ctive diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):15-19
Fluvoxamine in the treatment of anxiety-depressive spectrum diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):101-109
Anxiety diso­rders as como­rbid conditions in neuropsychiatric diseases in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):56-64

BACKGROUND

Alopecia areata (AA) is autoimmune disease of hair follicles which in some cases leads to significant area of hair loss and has a pronounced negative impact on patients’ life quality. Combination of AA with atopic diseases is currently assessed as risk of adverse AA course. The selection of atopy as a comorbid condition in AA has not only a predictive, but also a therapeutic and tactical importance, because allows to personalize treatment, planning systemic therapy with targeted pathogenetic preparations for such patients.

OBJECTIVE

To determine the occurrence of atopic diseases in AA and to assess clinical features of AA course combining with atopic diseases compared to AA without atopy.

MATERIAL AND METHODS

The number of patients with AA equal 146 aged 5–18 years, mean age 12.9±0.8 years, has been examined. Study group included 38 (26%) patients with confirmed comorbid atopic diseases (atopic dermatitis, allergic rhinitis, bronchial asthma). Control group consisted of 108 patients with AA and without atopic diseases. The following clinical parameters were assessed in both groups: patients’ age at the first visit, age of AA manifestation, number of events, duration of current event, area of hair loss, clinical phenotype of AA.

RESULTS

It has been demonstrated, that the average age of the manifestation of AA combined with atopic diseases was significantly lower than in group of patients suffered from AA without atopy (p=0.0017). Patients with comorbid atopic diseases had prevalently total and universal types of AA (S5B1-2N0-1) compared to patients without atopy (OR 3.37; 95% CI 1.07—10.61). There was a tendency to prevalence of AA clinical type in the form of ophiasis among patients with «atopic» AA type.

CONCLUSION

Atopy, as a comorbid condition in AA, is a prognostic unfavorable background referring to early onset and development of AA severe types.

Keywords:

alopecia areata
atopy
comorbidity
manifestation
severity

Authors:

Tereshchenko G.P.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

Potekaev N.N.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
The Russian National Research Medical University named after N.I. Pirogov

Gadzhigoroeva A.G.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Zhukova O.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology;
Peoples’ Friendship University of Russia

Golousenko I.Yu.

Russian University of Medicine

Received:

23.03.2023

Accepted:

18.01.2024

List of references:

  1. Lintzeri DA, Constantinou A, Hillmann K, Ghoreschi K, Vogt A, Blume-Peytavi U. Alopecia areata — Current understanding and management. J Dtsch Dermatol Ges. 2022;20(1):59-90.  https://doi.org/10.1111/ddg.14689
  2. Kridin K, Renert-Yuval Y, et al. Alopecia Areata Is Associated with Atopic Diathesis: Results from a Population-Based Study of 51,561 Patients. J Allergy Clin Immunol Ppract. 2020;8(4):1323-1328.e1.  https://doi.org/10.1016/j.jaip.2020.01.052
  3. Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;24(8): 397-403.  https://doi.org/10.2147/ccid.s53985
  4. Dainichi T, et al. Alopecia areata: What’s new in epidemiology, pathogenesis, diagnosis, and therapeutic options? J Dermatol Sci. 2017;86:3-12.  https://doi.org/10.1016/j.jdermsci.2016.10.004
  5. Gilhar A, Etzioni A, Paus R. Alopecia areata. N Engl J Med. 2012;366: 1515-1525. https://doi.org/10.1056/nejmra1103442
  6. Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol. 2006;20(9): 1055-1060. https://doi.org/10.1111/j.1468-3083.2006.01676.x
  7. Chu SY, Chen YJ, Tseng WC, et al. Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nation- wide population-based study. J Am Acad Dermatol. 2011;65(5):949-956.  https://doi.org/10.1016/j.jaad.2010.08.032
  8. Huang KP, Mullangi S, et al. Autoimmune, Atopic, and Mental Health Comorbid Conditions Associated with Alopecia Areata in the United States. JAMA Dermatol. 2013;149(7):789-794.  https://doi.org/10.1001/jamadermatol.2013.3049
  9. Mohan GC, Silverberg JI. Association of vitiligo and alopecia areata with atopic dermatitis: a systematic review and meta-analysis. JAMA Dermatol. 2014;151:522-528.  https://doi.org/10.1001/jamadermatol.2014.3324
  10. Barahmani N, Schabath MB, Duvic M. National Alopecia Areata Registry. History of atopy or autoimmunity increases risk of alopecia areata. J Am Acad Dermatol. 2009;61(4):581-591.  https://doi.org/10.1016/j.jaad.2009.04.031
  11. Lim CP, Severin RK, Petukhova L. Big data reveal insights into alopecia areata comorbidities. J Invest Dermatol Symp Proc. 2018;19:57-61.  https://doi.org/10.1016/j.jisp.2017.10.006
  12. Lee HJ, Hong N-S, et al. Association between Alopecia Areata and Comorbid Allergies: Implications for Its Clinical Course. Ann Dermatol. 2020; 32(6):523-525.  https://doi.org/10.5021/ad.2020.32.6.523
  13. Kaur S, Sharma VK, Kumar L, Kumar B. Atopy and alopecia areata in North Indians. Indian J Dermatol Venereol Leprol. 2002;68(5):267-269. PMID: 17656963.
  14. Ikeda T. New classification of alopecia areata. Dermatologica. 1965;131(6): 421-445. 
  15. Gadzhigoroeva AG. Treatment of patients with various clinical variants of alopecia areata, considering the pathogenetic features of the disease: Dis. ... d-ra. med. nauk. M. 2015. (In Russ.).
  16. Treatment of patients with alopecia areata considering the high activity of the process and the prevalence of hair loss. Guidelines for the Moscow City Health Department. 2019. Accessed Feb 11, 2023. (In Russ.). https://mosderm.ru/uploads/pages/method_rec/5e41c4f616f7.pdf
  17. Olsen EA. Alopecia areata investigational assessment guidelines--Part II. National Alopecia Areata Foundation. J Am Acad Dermatol. 2004;51(3):440-447.  https://doi.org/10.1016/j.jaad.2003.09.032
  18. Atopic dermatitis. Clinical guidelines. 2020 Accessed Feb 11, 2023. (In Russ.). https://cr.minzdrav.gov.ru/schema/265_2
  19. Olsen EA. Alopecia areata investigational assessment guidelines. National Alopecia Areata Foundation. J Am Acad Dermatol. 1999;40(2 Pt 1):242-246.  https://doi.org/10.1016/s0190-9622(99)70195-7
  20. Quireshi A, Friedman A. Comorbidities in Dermatology: What’s Real and What’s Not. Dermatol Clin. 2019;37(1):65-71.  https://doi.org/10.1016/j.det.2018.07.007
  21. Tosti A. Practice gaps. Alopecia areata and comorbid conditions. JAMA Dermatol. 2013;149(7):794.  https://doi.org/10.1001/jamadermatol.2013.360
  22. Thomsen SF. Epidemiology and natural history of atopic diseases. Eur Clin Respir J. 2015;2.  https://doi.org/10.3402/ecrj.v2.24642
  23. Ratnaparkhi R, Tellez A, Piliang M, Bergfeld W. Eosinophilia versus atopy as a predictor of severe phenotypes in alopecia areata Journal of the American Academy of Dermatology. 2016;74:5(suppl 1)(AB135). https://doi.org/10.1016/j.jaad.2016.02.530
  24. Alopecia areata. Clinical guidelines. 2020 Accessed Feb 11, 2023. (In Russ.). https://www.rodv.ru/upload/iblock/615/615258d9f33e185fa49b7e12fd3e2ecc.docx
  25. Lee HH, Gwillim E, Patel KR. et al. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis. J Am Acad Dermatol. 2020;82:675-682.  https://doi.org/10.1016/j.jaad.2019.08.032
  26. Cho HH, Jo SJ, Paik SH, et al. Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. J Korean Med Sci. 2012;27(7):799-802.  https://doi.org/10.3346/jkms.2012.27.7.799
  27. Lintzeri DA, Constantinou A, Hillmann K. et al. Alopecia areata — Current understanding and management. J Dtsch Dermatol Ges. 2022;20(1):59-90.  https://doi.org/10.1111/ddg.14689
  28. De Oliveira AB, Alpalhao M, et al. The role of Janus kinase inhibitors in the treatment of alopecia areata: A systematic review. Dermatologic Therapy. 2019;32:e13053. https://doi.org/10.1111/dth.13053
  29. Bakry OA, et al. Total serum immunoglobulin E in patients with alopecia areata. Indian Dermatol Online J. 2014;5(2):122-127.  https://doi.org/10.4103/2229-5178.131076
  30. Elsherif NA, et al. Study of total serum immunoglobulin E level and prevalence of atopy in alopecia areata patients. Iran J Dermatol. 2021;24:80-84.  https://doi.org/10.22034/ijd.2021.132451
  31. Sachdeva M, Witol A, et al. Alopecia Areata Related Paradoxical Reactions in Patients on Dupilumab Therapy: A Systematic Review. J Cutan Med Surg. 2021;25(4):464.  https://doi.org/10.1177/1203475421995186
  32. Sterkens A, Lambert J, et al. Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options. Clinical and Experimental Medicine. 2021;21:215-230.  https://doi.org/10.1007/s10238-020-00673-w

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.