Russian experts’ recommendations on the practical use of the filler VYC-25L

Avtomonov V.Yu.

«Medea Esthetic» clinic

Gutop E.O.

Peoples’ Friendship University of Russia;
Clinic “Actual”

Kalashnikova N.G.

«Linline» Clinic Chain

ORCID: 0000-0001-5250-9288

Kapuler O.M.

Center of Cosmetology, Plastic and Reconstructive Surgery

ORCID: 0000-0001-5714-5495

Kruglik E.V.

VIP-Clinic Moscow

Murakov S.V.

Academy of Postgraduate Education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency of Russia

ORCID: 0000-0003-4330-2570

Pozdeeva E.V.

«Linline» Clinic Chain

ORCID: 0000-0002-5507-9751

Razumovskaya E.A.

«Renaissance» clinic

Sokolova E.V.

Clinic «Galaxy»

Terentyeva L.V.

Beauty Class Clinic

Russian experts’ recommendations on the practical use of the filler VYC-25L

Authors:

Avtomonov V.Yu., Gutop E.O., Kalashnikova N.G., Kapuler O.M., Kruglik E.V., Murakov S.V., Pozdeeva E.V., Razumovskaya E.A., Sokolova E.V., Terentyeva L.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2021;20(5): 120‑127

DOI: 10.17116/klinderma202120051120

Downloaded: 44

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Avtomonov VYu, Gutop EO, Kalashnikova NG, et al. . Russian experts’ recommendations on the practical use of the filler VYC-25L. Russian Journal of Clinical Dermatology and Venereology. 2021;20(5):120‑127. (In Russ.)
https://doi.org/10.17116/klinderma202120051120

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)

Close metadata

Recommended articles:

Ultrasound characteristics of hyaluronic acid fillers tissue integration and hyaluronidase-mediated degradation. Russian Journal of Clinical Dermatology and Venereology. 2024;(3):322-331

Consensus recommendations on the use of biorevitalization in mono- and combination protocols of aesthetic treatment. Russian Journal of Clinical Dermatology and Venereology. 2024;(5):601-610

Clinical experimental study of the efficacy and safety of biorevitalization using a drug based on native hyaluronic acid modified by trehalose in patients with melasma. Russian Journal of Clinical Dermatology and Venereology. 2024;(5):612-618

Study of hardware methods impact on the physical properties of hyaluronic acid-based tissue fillers in experiment. Russian Journal of Clinical Dermatology and Venereology. 2025;(1):22-28

Effectiveness evaluation of IAL-System ACP in correction of age-related skin changes in periorbital area. Plastic Surgery and Aesthetic Medicine. 2024;(3):36-42

Application of fillers for intimate contour plasty in aesthetic gynecology. Russian Bulletin of Obstetrician-Gynecologist. 2024;(5):58-65

Evaluation of therapeutic efficiency of the combined nasal spray containing hyaluronic acid and alpha-tocopherol in postoperative period after endonasal surgery. Russian Rhinology. 2024;(4):283-295

Experimental modeling, prevention, and treatment of endometriosis-associated adhesion formation in NIH/3T3 fibroblast cell line using bovhyaluronidase azoximer (in vitro). Russian Journal of Human Reproduction. 2024;(6):61-72

Fatal non-thrombotic pulmonary embolism in penis enlargement with injections of hyaluronic acid-based drugs. Forensic Medical Expertise. 2025;(1):59-62

Aseptic osteitis of the tibia after intraarticular injection of hyaluronic acid in a patient with knee osteoarthritis. Russian Journal of Archive of Pathology. 2025;(2):69-72

Aesthetic treatments of the chin and jawline are becoming increasingly popular nowadays since special attention has been paid to the harmony of the lower face. One of the most used fillers in this facial area is VYC-25L. This filler has an extensive evidence base obtained during the non-clinical and clinical trials. After that many clinics around the world, including Russian ones, have started successful use of this product. However, despite the scientific evidence, aesthetic practitioners should be guided by approaches for the treatments with VYC-25L in different categories of patients. The presented article describes in detail the practical recommendations for aesthetic treatments with VYC-25L, considering the accumulated data of clinical trials and practical experience. These recommendations will be useful for cosmetologists and plastic surgeons for more effective and safe aesthetic treatments.

Keywords:

hyaluronic acid

fillers

aesthetic correction

lower third of the face

chin

facial contours

Authors:

Avtomonov V.Yu.

«Medea Esthetic» clinic

Gutop E.O.

Peoples’ Friendship University of Russia;
Clinic “Actual”

Kalashnikova N.G.

«Linline» Clinic Chain

ORCID: 0000-0001-5250-9288

Kapuler O.M.

Center of Cosmetology, Plastic and Reconstructive Surgery

ORCID: 0000-0001-5714-5495

Kruglik E.V.

VIP-Clinic Moscow

Murakov S.V.

Academy of Postgraduate Education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency of Russia

ORCID: 0000-0003-4330-2570

Pozdeeva E.V.

«Linline» Clinic Chain

ORCID: 0000-0002-5507-9751

Razumovskaya E.A.

«Renaissance» clinic

Sokolova E.V.

Clinic «Galaxy»

Terentyeva L.V.

Beauty Class Clinic

Received:

21.07.2021

Accepted:

12.09.2021

List of references:

How Frequently Are Dermal Filler Treatments Done? About Plastic Surgery. Accessed June 11, 2021. https://www.aboutplasticsurgery.com/skin/dermal-fillers/dermal-fillers-frequency-of-treatment/
Lee EI. Aesthetic Alteration of the Chin. Semin Plast Surg. 2013;27(3):155-160. https://doi.org/10.1055/s-0033-1357113
Frodel JL, Sykes JM. Chin augmentation/genioplasty: chin deformities in the aging patient. Facial Plast Surg. 1996;12(3):279-283. https://doi.org/10.1055/s-0028-1082418
Zide BM, Boutros S. Chin surgery III: revelations. Plast Reconstr Surg. 2003;111(4):1542-1550; discussion 1551-1552. https://doi.org/10.1097/01.PRS.0000049635.68551.FF
Kapuler OM. Contour correction of the lower face: innovative hyaluronic acid-based filler Juvederm Volux. Plasticheskaja Hirurgija I Jesteticheskaja Medicina. 2020;4:52-57. (In Russ.). https://doi.org/10.17116/plast.hirurgia202004152
Kapuler OM. Hyaluronic acid fillers: what is important to know? Kosmetika i Medicina. 2018;(4):35-38. (In Russ.).
Health C for D and R. Juvéderm Voluma — P110033/S047. FDA. Published online July 7, 2020. Accessed June 11, 2021. https://www.fda.gov/medical-devices/recently-approved-devices/juvedermr-volumatm-xc-p110033s047
Thayer ZM, Dobson SD. Geographic Variation in Chin Shape Challenges the Universal Facial Attractiveness Hypothesis. PLoS One. 2013;8(4):e60681. https://doi.org/10.1371/journal.pone.0060681
Mastroluca E, Patalano M, Bertossi D. Minimally invasive aesthetic treatment of male patients: The importance of consultation and the lower third of the face. J Cosmet Dermatol. 2021;20(7):2086-2092. Published online May 16, 2021. https://doi.org/10.1111/jocd.14231
Henderson A. Focusing on chin augmentation: treating the lower face using dermal filler. Journal of Aesthetic Nursing. 2020;9(5):191-194. https://doi.org/10.12968/joan.2020.9.5.191
Allergan. When you want to define the lower face. Information for healthcare professionals. 2019.
Mommaerts MY, Shteif M, Hendrickx K, Laster Z. Surgical options in deep-bite mandibular deficiency with prominent chin — aesthetic considerations. J Craniomaxillofac Surg. 2004;32(2):112-118. https://doi.org/10.1016/j.jcms.2003.09.005
Naini FB, Cobourne MT, McDonald F, Wertheim D. Submental-Cervical Angle: Perceived Attractiveness and Threshold Values of Desire for Surgery. J Maxillofac Oral Surg. 2016;15(4):469-477. https://doi.org/10.1007/s12663-015-0872-4
de Maio M. Myomodulation with Injectable Fillers: An Update. Aesthetic Plast Surg. 2020;44(4):1317-1319. https://doi.org/10.1007/s00266-020-01768-1
de Maio M. Myomodulation with Injectable Fillers: An Innovative Approach to Addressing Facial Muscle Movement. Aesth Plast Surg. 2018; 42(3):798-814. https://doi.org/10.1007/s00266-018-1116-z
Valenzano DR, Mennucci A, Tartarelli G, Cellerino A. Shape analysis of female facial attractiveness. Vision Res. 2006;46(8-9):1282-1291. https://doi.org/10.1016/j.visres.2005.10.024
Malloy TE, DiPietro C, DeSimone B, Curley C, Chau S, Silva C. Facial attractiveness, social status, and face recognition. Visual Cognition. 2021;29(3): 158-179. https://doi.org/10.1080/13506285.2021.1884630
Little AC, Jones BC, DeBruine LM. Facial attractiveness: evolutionary based research. Philos Trans R Soc Lond B Biol Sci. 2011;366(1571):1638-1659. https://doi.org/10.1098/rstb.2010.0404
Bloom JD. Emerging Trends, Techniques, and Technologies in Facial Plastic and Reconstructive Surgery. Facial Plast Surg Clin North Am. 2019;27(3): xiii-xiv. https://doi.org/10.1016/j.fsc.2019.04.010
Ward J, Podda S, Garri JI, Wolfe SA, Thaller SR. Chin deformities. J Craniofac Surg. 2007;18(4):887-894. https://doi.org/10.1097/scs.0b013e3180684401
Mendelson B, Wong C-H. Changes in the facial skeleton with aging: implications and clinical applications in facial rejuvenation. Aesthetic Plast Surg. 2012;36(4):753-760. https://doi.org/10.1007/s00266-012-9904-3
Swift A, Remington K. BeautiPHIcation: a global approach to facial beauty. Clin Plast Surg. 2011;38(3):347-377. https://doi.org/10.1016/j.cps.2011.03.012
Ogilvie P, Sattler G, Gaymans F, Belhaouari L, Weichman BM, Snow S, Chawla S, Abrams S, Schumacher S. Safe, Effective Chin and Jaw Restoration With VYC-25L Hyaluronic Acid Injectable Gel. Dermatol Surg. 2019; 45(10):1294-1303. https://doi.org/10.1097/DSS.0000000000001960
Ogilvie P, Benouaiche L, Philipp-Dormston WG, Gaymans F, Belhaouari L, Schumacher A, Sattler G, Harvey C. VYC-25L Hyaluronic Acid Injectable Gel Is Safe and Effective for Long-Term Restoration and Creation of Volume of the Lower Face. Aesthet Surg J. 2020;40(9):NP499-NP510. https://doi.org/10.1093/asj/sjaa013
Bertossi D, Robiony M, Lazzarotto A, Giampaoli G, Nocini R, Nocini PF. Nonsurgical Redefinition of the Chin and Jawline of Younger Adults With a Hyaluronic Acid Filler: Results Evaluated With a Grid System Approach. Aesthet Surg J. Published online September 2021;41(9):1068–1076. https://doi.org/10.1093/asj/sjaa179
Urdiales-Gálvez F, Barres-Caballer J, Carrasco-Sánchez S. Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC-25L in facial lower-third aesthetic treatment: A prospective multicenter study. Journal of Cosmetic Dermatology. 2021;20(5):1439-1449. https://doi.org/10.1111/jocd.13632
Raspaldo H. Volumizing effect of a new hyaluronic acid sub-dermal facial filler: a retrospective analysis based on 102 cases. J Cosmet Laser Ther. 2008; 10(3):134-142. https://doi.org/10.1080/14764170802154607
Hoffmann K, Juvéderm Voluma Study Investigators Group. Volumizing effects of a smooth, highly cohesive, viscous 20-mg/mL hyaluronic acid volumizing filler: prospective European study. BMC Dermatol. 2009;9:9. https://doi.org/10.1186/1471-5945-9-9
Callan P, Goodman GJ, Carlisle I, Liew S, Muzikants P, Scamp T, Halstead MB, Rogers J. Efficacy and safety of a hyaluronic acid filler in subjects treated for correction of midface volume deficiency: a 24 month study. Clin Cosmet Investig Dermatol. 2013;6:81-89. https://doi.org/10.2147/CCID.S40581
Few J, Cox SE, Paradkar-Mitragotri D, Murphy DK. A Multicenter, Single-Blind Randomized, Controlled Study of a Volumizing Hyaluronic Acid Filler for Midface Volume Deficit: Patient-Reported Outcomes at 2 Years. Aesthet Surg J. 2015;35(5):589-599. https://doi.org/10.1093/asj/sjv050
de Maio M. MD CodesTM: A Methodological Approach to Facial Aesthetic Treatment with Injectable Hyaluronic Acid Fillers. Aesthetic Plast Surg. 2021;45(2):690-709. https://doi.org/10.1007/s00266-020-01762-7
Label information for Juvéderm VoluxTM. January 2019.
Kruglik EV, Likhtinova AN, Saromytskaya AN, Chebotareva YuYu, Yusova ZhYu. The use of cryolipolysis for body contouring as monotherapy and in combination with other methods of aesthetic correction. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2020;19(5):771-780. (In Russ.). https://doi.org/10.17116/klinderma202019051771
Casabona G, Kaye K. Facial Skin Tightening With Microfocused Ultrasound and Dermal Fillers: Considerations for Patient Selection and Outcomes. J Drugs Dermatol. 2019;18(11):1075-1082.
Alam M, Levy R, Pajvani U, Ramierez J, Guitart J, Veen H, Gladstone H. Safety of radiofrequency treatment over human skin previously injected with medium-term injectable soft-tissue augmentation materials: a controlled pilot trial. Lasers Surg Med. 2006;38(3):205-210. https://doi.org/10.1002/lsm.20241
Shumaker PR, England LJ, Dover JS, Ross EV, Harford R, Derienzo D, Bogle M, Uebelhoer N, Jacoby M, Pope K. Effect of monopolar radiofrequency treatment over soft-tissue fillers in an animal model: part 2. Lasers Surg Med. 2006;38(3):211-217. https://doi.org/10.1002/lsm.20292
England LJ, Tan M-H, Shumaker PR, Egbert B, Pittelko K, Orentreich D, Pope K. Effects of monopolar radiofrequency treatment over soft-tissue fillers in an animal model. Lasers Surg Med. 2005;37(5):356-365. https://doi.org/10.1002/lsm.20253
Kalashnikova NG, Pozdeeva EV. Combined approach to the correction of age-related facial changes: laser technologies, botulinum toxin and hyaluronic acid fillers. Russian Journal of Clinical Dermatology and Venereology = Klinichaskaya dermatologiya i venerologiya. 2021;20(2):104-113. (In Russ.). https://doi.org/10.17116/klinderma202120021104
Ribé A, Ribé N. Neck skin rejuvenation: histological and clinical changes after combined therapy with a fractional non-ablative laser and stabilized hyaluronic acid-based gel of non-animal origin. J Cosmet Laser Ther. 2011; 13(4):154-161. https://doi.org/10.3109/14764172.2011.594060
Gutop EO, Murakov SV. Possibilities of combined protocols in the treatment of age-related changes in the face: fillers, botulinum toxin and thread methods. Plastic Surgery and Aesthetic Medicine. 2021;3:92-101. (In Russ.). https://doi.org/10.17116/plast.hirurgia202103192
Kim B, Oh S, Jung W. The Art and Science of Thread Lifting: Based on Pinch Anatomy. Springer Singapore; 2019. https://doi.org/10.1007/978-981-13-0614-3
Cavallini M, Pierce A, Nakab L. In Vivo Degradation of Juvéderm® Volux™ Compared With Other Hyaluronic Acid–based Fillers Following Injection of Hyaluronidase. Presented at the ISAPS World Congress 2021, Vienna, Austria, September 11-13, 2021.
Kurshakova KM. A new level of drugs for the correction of the lower third of the face. Nauchno-prakticheskoe obshhestvo vrachej kosmetologi g. Sankt-Peterburg. Sbornik statej N 22, 2021. (In Russ.).

Close metadata