The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Goldobina M.V.

Atypical Clinic LLC, St. Petersburg, Russia

Controlled study of the efficacy and safety of correction of wrinkles in anatomically complex areas using hyaluronic acid and low-temperature plasma drugs in mono- and combination therapies

Authors:

Goldobina M.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2026;25(2): 293‑300

DOI: 10.17116/klinderma202625021293

Read: 278 times

Contact the author
Table of contents

CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF CORRECTION OF WRINKLES IN ANATOMICALLY COMPLEX AREAS USING HYALURONIC ACID AND LOW-TEMPERATURE PLASMA DRUGS IN MONO- AND COMBINATION THERAPIES
CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF CORRECTION OF WRINKLES IN ANATOMICALLY COMPLEX AREAS USING HYALURONIC ACID AND LOW-TEMPERATURE PLASMA DRUGS IN MONO- AND COMBINATION THERAPIES

To cite this article:

Goldobina MV. Controlled study of the efficacy and safety of correction of wrinkles in anatomically complex areas using hyaluronic acid and low-temperature plasma drugs in mono- and combination therapies. Russian Journal of Clinical Dermatology and Venereology. 2026;25(2):293‑300. (In Russ.)
https://doi.org/10.17116/klinderma202625021293

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Therapeutic pote­ntial of hyaluronic acid and poly­lactic acid for the treatment of atro­phic scars. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):512-522
Rosa­cea: from multifactorial pathogenesis to modern treatment methods. Russian Journal of Clinical Dermatology and Vene­reology. 2026;(1):23-30
Features of the layer-by-layer soft tissue stru­cture of the upper face in terms of the use of hyaluronic acid-based fillers under ultrasound control. Russian Journal of Clinical Dermatology and Vene­reology. 2026;(1):129-140
Expe­rimental mode­ling and treatment of endo­metriosis using bovhyaluronidase azoximer in an animal model. Russian Journal of Human Reproduction. 2025;(4):26-40
Effi­cacy and safety of dermal filler based on poly-D,L-lactic acid. Plastic Surgery and Aesthetic Medi­cine. 2025;(3):38-48
Morphological and immu­nohistochemical characteristics of skin specimens after isolated and combined inje­ctions of poly-L-lactic acid and hyaluronic acid. Plastic Surgery and Aesthetic Medi­cine. 2025;(3):50-62
Effi­cacy and safety of inje­ctable complex of stabilized and native hyaluronic acid and sorbitol for lip skin hydration in patients taking systemic reti­noids. Plastic Surgery and Aesthetic Medi­cine. 2025;(3):64-70
Oxidative stress and depression in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):131-138
Study of the physicomechanical properties and hydrolysis resi­stance of mate­rials based on photopolymerizable hyaluronic acid and polye­thyleneglycol diacrylate composites. Stomatology. 2025;(6-2):5-11
The influence of poly­mer addi­tives in the composition of implantable matrices based on collagen and hyaluronic acid on their degradation in vitro. Stomatology. 2025;(6-2):94-99
Abstract:

The skin aging process is multifactorial, which creates prerequisites to searching for combined methods of correcting age-related changes. Data of study on the efficacy and safety of using dermal implants on the basis of hyaluronic acid and sorbitol in mono- or combination therapy with low-temperature plasma exposure for correcting age-related changes of the skin of the periorbital region and neck are presented. Volunteers (n=45) were divided into 3 groups. Group 1 patients underwent 2 injections of semi-cross-linked hyaluronic acid and sorbitol, group 2 — 3 procedures of treatment with «cold» plasma, group 3 — a combined protocol of 2 injections of hyaluronic acid and 3 «cold» plasma procedures. The assessment was carried out by means of photo documentation and mDLQI and GAIS questionnaires. Subjects in all groups demonstrated improvement in quality of life indicators according to the mDLQI, high degree of satisfaction with the aesthetic results according to the GAIS and statistically significant reduction in wrinkle depth, but the best results were found in groups 1 and 3. Thus, this study demonstrates the efficacy and safety of using semi-cross-linked hyaluronic acid and low-temperature plasma for correction of wrinkles of the periorbital region in both mono- and combination therapies.

Keywords:

hyaluronic acid
sorbitol
low-temperature plasma
«cold» plasma
combined therapy
wrinkles
skin quality
periorbital region
neck skin

Authors:

Goldobina M.V.

Atypical Clinic LLC, St. Petersburg, Russia

Received:

16.01.2026

Accepted:

27.02.2026

Close metadata

References:

  1. Friedman O. Changes associated with the aging face. Facial Plast Surg Clin North Am. 2005 Aug;13(3):371-380. PMID: 16085282. https://doi.org/10.1016/j.fsc.2005.04.004
  2. Gupta MA, Gilchrest BA. Psychosocial aspects of aging skin. Dermatol Clin. 2005 Oct;23(4):643-648. PMID: 16112440. https://doi.org/10.1016/j.det.2005.05.012
  3. Albert AM, Ricanek K Jr, Patterson E. A review of the literature on the aging adult skull and face: implications for forensic science research and applications. Forensic Sci Int. 2007 Oct 2;172(1):1-9. Epub 2007 Apr 16. PMID: 17434276. https://doi.org/10.1016/j.forsciint.2007.03.015
  4. Hussein RS, Bin Dayel S, Abahussein O, El-Sherbiny AA. Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. J Cosmet Dermatol. 2025 Feb;24(2):e16688. Epub 2024 Nov 27. PMID: 39604792; PMCID: PMC11845971. https://doi.org/10.1111/jocd.16688
  5. Uitto J. The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure. J Drugs Dermatol. 2008 Feb;7(2 Suppl):s12-6. PMID: 18404866.
  6. Nikolaeva NN, Malova IO. On the issue of increasing patient satisfaction with the results of cosmetic procedures. Farmateka. 2022;29(8):85-90. (In Russ.). https://doi.org/10.18565/pharmateca.2022.8.85-90
  7. Olisova OYu, Krasil`nikova ON. Socio-hygienic research and assessment of the quality of life of cosmetology patients. Rossijskij zhurnal kozhny`x i venericheskix boleznej. 2021;24(3):307-314. (In Russ.). https://doi.org/10.17816/dv71454
  8. Alimova SM, Sharobaro VI, Shamanaeva LS, Penaeva SA. Psychometric scales in assessing patient satisfaction with the results of aesthetic face and neck correction. Plastic Surgery and Aesthetic Medicine. 2021;(4):77-82. (In Russ., In Engl.). https://doi.org/10.17116/plast.hirurgia202104177
  9. Shakhnovich AA, Ragimova AA, Samushiya MA, Efremov AA. Mental status of patients in cosmetology as predictor of satisfaction with aesthetic procedures and psychometric scales for its assessment (literature review). Medical alphabet. 2019;2(26):5-11. (In Russ.). https://doi.org/10.33667/2078-5631-2019-2-26(401)-5-11
  10. Ramos-E-Silva M, Fonteles LA, Lagalhard CS, Fucci-da-Costa AP. STYLAGE®: a range of hyaluronic acid dermal fillers containing mannitol. Physical properties and review of the literature. Clin Cosmet Investig Dermatol. 2013 Oct 23;6:257-261. PMID: 24187508; PMCID: PMC3810198. https://doi.org/10.2147/CCID.S35251
  11. Zhou R, Yu M. The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025 Jan;24(1):e16760. PMID: 39807700; PMCID: PMC11731322. https://doi.org/10.1111/jocd.16760
  12. Sapon AM, Gutop EO, Akhmedbaeva IA, Korzun YuL, Rumak AS. Randomized study of efficacy and safety of combined application of hyaluronic acid-based dermal implants, IPL technology and non-ablative laser fractional resurfacing for age-related changes correction. Russian Journal of Clinical Dermatology and Venereology. 2025;24(1):94-101. (In Russ.). https://doi.org/10.17116/klinderma20252401194
  13. Karagadyan AD. Efficacy and safety of injectable complex of stabilized and native hyaluronic acid and sorbitol for lip skin hydration in patients taking systemic retinoids. Plastic Surgery and Aesthetic Medicine. 2025;(3):64-70. (In Russ., In Engl.). https://doi.org/10.17116/plast.hirurgia202503164
  14. Korotkiĭ VN. The use of low-temperature atmospheric plasma in dermatology. Russian Journal of Clinical Dermatology and Venereology. 2017;16(5):4-11. (In Russ.). https://doi.org/10.17116/klinderma20171654-10
  15. Shemshuk MI, Korotkij VN, Serov DN, Kochetkov MA, Sten`ko AG, Korotkij NG. Low-temperature atmospheric plasma in the correction of age-related skin changes. Vestnik RGMU. 2018;2:60-66. (In Russ.). https://doi.org/10.24075/vrgmu.2018.018
  16. Kisch T, Helmke A, Schleusser S, Song J, Liodaki E, Stang FH, Mailaender P, Kraemer R. Improvement of cutaneous microcirculation by cold atmospheric plasma (CAP): Results of a controlled, prospective cohort study. Microvasc Res. 2016 Mar;104:55-62. Epub 2015 Dec 3. PMID: 26655582. https://doi.org/10.1016/j.mvr.2015.12.002
  17. Khalaf AT, Abdalla AN, Ren K, Liu X. Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare. Eur J Med Res. 2024 Oct 5;29(1):487. PMID: 39367460; PMCID: PMC11453049. https://doi.org/10.1186/s40001-024-02088-9
  18. Bai F, Ran Y, Zhai S, Xia Y. Cold Atmospheric Plasma: A Promising and Safe Therapeutic Strategy for Atopic Dermatitis. Int Arch Allergy Immunol. 2023;184(12):1184-1197. Epub 2023 Sep 13. PMID: 37703833; PMCID: PMC10733932. https://doi.org/10.1159/000531967
  19. Nam SH, Choi JH, Kim GC. Topical Application of No-Ozone Cold Plasma in Combination with Vitamin C Reduced Skin Redness and Pigmentation of UV-Irradiated Mice. Biomedicines. 2023 May 27;11(6):1563. PMID: 37371658; PMCID: PMC10294968. https://doi.org/10.3390/biomedicines11061563
  20. Shakouri R, Khani MR, Samsavar S, Jezeh MA, Abdollahimajd F, Hosseini SI, Dilmaghanian A, Ghasemi E, Alihoseini MR, Shokri B. In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation. Sci Rep. 2021 Nov 9;11(1):21915. PMID: 34753995; PMCID: PMC8578492. https://doi.org/10.1038/s41598-021-01341-z
  21. Wang L, Ren M, Chen C, Yang X, Zhang C, Gao J, Wang J, Yang C. Cold atmospheric plasma in combination with laser therapy provides a window for the treatment of hyperproliferative skin disease. Photodiagnosis Photodyn Ther. 2024 Aug;48:104243. Epub 2024 Jun 9. PMID: 38862086. https://doi.org/10.1016/j.pdpdt.2024.104243
  22. Bernhardt T, Semmler ML, Schäfer M, Bekeschus S, Emmert S, Boeckmann L. Plasma Medicine: Applications of Cold Atmospheric Pressure Plasma in Dermatology. Oxid Med Cell Longev. 2019 Sep 3;2019:3873928. PMID: 31565150; PMCID: PMC6745145. https://doi.org/10.1155/2019/3873928
  23. Tan F, Wang Y, Zhang S, Shui R, Chen J. Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma. Front Oncol. 2022 Jul 12;12:918484. PMID: 35903680; PMCID: PMC9314643. https://doi.org/10.3389/fonc.2022.918484
  24. Gentile RD. Renuvion RF-Helium Plasma for Subdermal Skin Tightening, Facial Contouring and Skin Rejuvenation of the Face and Neck. Facial Plast Surg Aesthet Med. 2020 Jul/Aug;22(4):304-306. Epub 2020 May 5. PMID: 32379988; PMCID: PMC7374633. https://doi.org/10.1089/fpsam.2020.0070
  25. Lee S, Yen MT. Nonsurgical Rejuvenation of the Eyelids with Hyaluronic Acid Gel Injections. Semin Plast Surg. 2017 Feb;31(1):17-21. PMID: 28255285; PMCID: PMC5330790  https://doi.org/10.1055/s-0037-1598189
  26. Berguiga M, Galatoire O. Tear trough rejuvenation: A safety evaluation of the treatment by a semi-cross-linked hyaluronic acid filler. Orbit. 2017 Feb;36(1):22-26. Epub 2017 Jan 25. PMID: 28121477. https://doi.org/10.1080/01676830.2017.1279641
  27. Razumovskaya EA, Murakov SV, Artemenko AR, Kurenkov AL. Study of facial muscles function after the chin treatment with hyaluronic acid filler. Plastic Surgery and Aesthetic Medicine. 2024;1:84-95. (In Russ.). https://doi.org/10.17116/plast.hirurgia202401184
  28. Makhova OA. Monitoring the safety of medical devices in plastic surgery and cosmetology. Plastic Surgery and Aesthetic Medicine. 2024;1:96-102. (In Russ.). https://doi.org/10.17116/plast.hirurgia202401196
  29. Razumovskaya EA, Murakov SV, Artemenko AR, Kurenkov AL. Study of facial muscles function after the chin treatment with hyaluronic acid filler. Plastic Surgery and Aesthetic Medicine. 2024;1:84-95. (In Russ.). https://doi.org/10.17116/plast.hirurgia20240184
  30. Chaikovskaya EA, Rodina YuA, Manturova NE, Stenko AG. Patient assessment of effectiveness of facial skin biorevitalization procedures:a prospective study. Plastic Surgery and Aesthetic Medicine. 2023;4:93-100. (In Russ.). https://doi.org/10.17116/plast.hirurgia202304193
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.