Botulinum toxin type A injection in the middle and lower thirds of the face and neck area for aesthetic purposes

Sharova A.A.

doi:https://doi.org/10.17116/plast.hirurgia2025031108

Sharova A.A.

Clinic of Aesthetic Medicine “Chistye Prudy”;
Pirogov Russian National Research Medical University

ORCID: 0000-0003-2148-5740

Botulinum toxin type A injection in the middle and lower thirds of the face and neck area for aesthetic purposes

Authors:

Sharova A.A.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2025;(3): 108‑117

DOI: 10.17116/plast.hirurgia2025031108

Read: 451 times

To cite this article:

Sharova AA. Botulinum toxin type A injection in the middle and lower thirds of the face and neck area for aesthetic purposes. Plastic Surgery and Aesthetic Medicine. 2025;(3):108‑117. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia2025031108

Подписка 2026 Пластическая хирургия и эстетическая медицина (Plastic Surgery and Aesthetic Medicine)

Использование инфографики авторами научных работ

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Abstract:

The use of botulinum toxin type A in the middle and lower thirds of the face and neck area is widely practiced by doctors all over the world, but these manipulations still remain off-label. Russian specialists have a great advantage for is the opportunity, because they can work in a legal field, since the instructions for Russian botulinum toxin type A provide recommendations for their use in the middle and lower half of the face and neck. It is even more interesting to study the experience of foreign colleagues and compare it with the recommendations that are reflected in the permitted indications for the use of Russian botulinum toxin type A in the middle and lower thirds of the face and platysmal bands.

Keywords:

botulinum toxin type A

middle third of the face

lower third of the face

platysma

masseter muscle

Authors:

Sharova A.A.

Clinic of Aesthetic Medicine “Chistye Prudy”;
Pirogov Russian National Research Medical University

ORCID: 0000-0003-2148-5740

Received:

22.01.2025

Accepted:

07.02.2025

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References:

Monheit GD, Pickett A. AbobotulinumtoxinA: A 25-Year History. Aesthet Surg J. 2017 May 01;37(Suppl 1):S4-S11. https://doi.org/10.1093/asj/sjw284
Warren H, Welch K, Coquis-Knezek S. AbobotulinumtoxinA for Facial Rejuvenation: What Affects the Duration of Efficacy? Plastic Surgical Nursing. 2020;40(1):37-44. https://doi.org/10.1097/PSN.0000000000000292
Scaglione F. Conversion Ratio between Botox, Dysport, and Xeomin in Clinical Practice. Toxins (Basel). 2016 Mar 04;8(3):65. https://doi.org/10.3390/toxins8030065
Sharova AA. Comparison of different consensuses of BTXA in different countries. J Cosmet Dermatol. 2016 Dec;15(4):540-548. https://doi.org/10.1111/jocd.12287
Choudhury S, Baker MR, Chatterjee S, Kumar H. Botulinum Toxin: An Update on Pharmacology and Newer Products in Development. Toxins (Basel). 2021 Jan 14;13(1):58. https://doi.org/10.3390/toxins13010058
Dressler D, Johnson EA. Botulinum toxin therapy: past, present and future developments. J Neural Transm (Vienna). 2022 June;129(5-6):829-833. https://doi.org/10.1007/s00702-022-02494-5
Kassir M, Babaei M, Hasanzadeh S, Rezaei Tavirani M, Razzaghi Z, Robati RM. Botulinium toxin applications in the lower face and neck: A comprehensive review. J Cosmet Dermatol. 2024 Apr;23(4):1205-1216. https://doi.org/10.1111/jocd.16116
Sundaram H, Signorini M, Liew S, Trindade de Almeida AR, Wu Y, Vieira Braz A, Fagien S, Goodman GJ, Monheit G, Raspaldo H; Global Aesthetics Consensus Group. Global Aesthetics Consensus: Botulinum Toxin Type A — Evidence-Based Review, Emerging Concepts, and Consensus Recommendations for Aesthetic Use, Including Updates on Complications. Plast Reconstr Surg. 2016 Mar;137(3):518e-529e. https://doi.org/10.1097/01.prs.0000475758.63709.23
Yutskovskaya Y, Gubanova E, Khrustaleva I, Atamanov V, Saybel A, Parsagashvili E, Dmitrieva I, Sanchez E, Lapatina N, Korolkova T, Saromytskaya A, Goltsova E, Satardinova E. IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations. Clin Cosmet Investig Dermatol. 2015 June 05;8:297-306. https://doi.org/10.2147/CCID.S72301
Ascher B, Rzany BJ, Kestemont P, Redaelli A, Hendrickx B, Iozzo I, Martschin C, Milotich A, Molina B, Cartier H, Picaut P, Prygova I. International Consensus Recommendations on the Aesthetic Usage of Ready-to-Use AbobotulinumtoxinA (Alluzience). Aesthet Surg J. 2024 Jan 16;44(2): 192-202. https://doi.org/10.1093/asj/sjad222
Lorenc ZP, Corduff N, van Loghem J, Yoelin S. Creating Lift in the Lower Face With Botulinum Toxin A Treatment: An Anatomical Overview With Videos and Case Studies Illustrating Patient Evaluation and Treatment. Aesthet Surg J Open Forum. 2022 May 02;4:ojac034. https://doi.org/10.1093/asjof/ojac034
Redaelli A, Saromytskaya A, Rowland Payne C, Manturova N, Battistella M, Saban Y, Panova O, Wollina U, Landau M, Atamanov V, Gavasheli L, Sanches E, Gubanova E, Orlova O, Diaspro A, Kobaladze N, Reznik A, Lukyanau A, Sharova A, Zhaboeva S, Holod O, Zhumatova G, Goltsova E, Soiher M, Chaikovskaya E, Chebotareva J, Parsagashvili E. International expert consensus on the use of AboBotulinum Toxin A (AboTA) for facial rejuvenation and primary hyperhidrosis. CosMed. 2017;3(2):70-80.
Bertossi D, Cavallini M, Cirillo P, Piero Fundarò S, Quartucci S, Sciuto C, Tonini D, Trocchi G, Signorini M. Italian consensus report on the aesthetic use of onabotulinum toxin A. J Cosmet Dermatol. 2018 Oct;17(5):719-730. https://doi.org/10.1111/jocd.12729
von Arx T, Nakashima MJ, Lozanoff S. The Face — A Musculoskeletal Perspective. A literature review. Swiss Dent J. 2018 Sept 10;128(9):678-688. https://doi.org/10.61872/sdj-2018-09-442
Hur MS, Hu KS, Cho JY, Kwak HH, Song WC, Koh KS, Lorente M, Kim HJ. Topography and location of the depressor anguli oris muscle with a reference to the mental foramen. Surg Radiol Anat. 2008 July;30(5):403-407. https://doi.org/10.1007/s00276-008-0343-4
Ohana O, Fezza JP, Sykes J, Yoelin SG, Lee JH, Fezza RM, Lee WW. The Platysma Contraction Pattern in Healthy Adults: A Vector Analysis Study. Plast Reconstr Surg. 2024 Mar 01;153(3):601-607. https://doi.org/10.1097/PRS.0000000000010630
Sharova AA, Khatkova SE. Mezhdistsiplinarnye aspekty korrektsii platizmy preparatom Relatoks®. Metamorfozy (Vestnik MOOSBT). 2024;47:76-88. (In Russ.).
Levy PM. The ‘Nefertiti lift’: a new technique for specific re-contouring of the jawline. J Cosmet Laser Ther. 2007;9(4):249‐252. https://doi.org/10.1080/14764170701545657
Sharova AA. Mimic patterns of the lower third of the face and botulinum therapy for facial contour correction. Plastic Surgery and Aesthetic Medicine. 2020;(4):41-51. (In Russ.). https://doi.org/10.17116/plast.hirurgia202004141
Yi K-H, Lee H-J, Hur H-W, Seo KK, Kim H-J. Guidelines for Botulinum Neurotoxin Injection for Facial Contouring. Plast Reconstr Surg. 2022 Sept 01;150(3):562e-571e. https://doi.org/10.1097/PRS.0000000000009444
IMP LP-005821 MIOTOKS Botulinicheskij toksin tipa A — gemagglyutinin kompleks. (In Russ.).
IMP LP-001593 RELATOKS Toksin botulinicheskij tipa A v komplekse s gemagglyutininom. (In Russ.).
Plotnikova EV, Elkin VD. Experimental and clinical test on safety and medical effectivness of native Botulinic toxin of A-type Relatox for correction of wrinles. Zdorov’e sem’i — 21 vek. 2011;4(4):11. (In Russ.).
Wang C, Sun T, Li H, Li Z, Wang X. Hypersensitivity Caused by Cosmetic Injection: Systematic Review and Case Report. Aesthetic Plastic Surgery. 2021 Feb;45(1):263-272. Epub 2020 Mar 23. PMID: 32206863. https://doi.org/10.1007/s00266-020-01684-4
Wee SY, Park ES. Immunogenicity of botulinum toxin. Arch Plast Surg. 2022 Jan;49(1):12-18. https://doi.org/10.5999/aps.2021.00766
Sidorov DV, Starozhuk NV. Izuchenie klinicheskikh effektov i markerov allergii pri korrektsii mimicheskikh morshchin preparatom Relatoks. In”ektsionnye metody v kosmetologii. 2016;1:8-11. (In Russ.).
Manturova NE, Chajkovskaya EA, Timerbaeva SL. Botulinum toxin therapy: what do we have and what do we see on the horizon? Plastic Surgery and Aesthetic Medicine. 2020;(2):70-80. (In Russ.). https://doi.org/10.17116/plast.hirurgia202002170
Kaminer MS, Cox SE, Fagien S, Kaufman J, Lupo MP, Shamban A. Re-examining the Optimal Use of Neuromodulators and the Changing Landscape: A Consensus Panel Update. J Drugs Dermatol. 2020 Apr 01;19(4):s5-s15. Erratum in: J Drugs Dermatol. 2020 May 01;19(5):S1545961620P0e28X.
Kolsanova OA, Suslin SA. Organizational aspects of the use of medicines in cosmetology clinics. Sovremennye problemy zdravookhraneniya i meditsinskoj statistiki. 2022;5;564-581. (In Russ.). Accessed November 22, 2024. https://cyberleninka.ru/article/n/organizatsionnye-aspekty-primeneniya-lekarstvennyh-preparatov-v-kosmetologicheskih-klinikah