Clinical and morphological features of psoriasis of the scalp depending on contamination by fungi of the genus Malassezia

Kornisheva V.G.

North-Western State Medical University named after I.I. Mechnikov

Smolina O.A.

North-Western State Medical University named after I.I. Mechnikov

Stepanova A.A.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-4029-9401

Avdeenko Y.L.

Kashkin Research Institute of Medical Mycology

Raznatovsky K.I.

North-Western State Medical University named after I.I. Mechnikov

ORCID: 0000-0003-1022-7463

Clinical and morphological features of psoriasis of the scalp depending on contamination by fungi of the genus Malassezia

Authors:

Kornisheva V.G., Smolina O.A., Stepanova A.A., Avdeenko Y.L., Raznatovsky K.I.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(3): 366‑372

DOI: 10.17116/klinderma202019031366

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To cite this article:

Kornisheva VG, Smolina OA, Stepanova AA, Avdeenko YL, Raznatovsky KI. Clinical and morphological features of psoriasis of the scalp depending on contamination by fungi of the genus Malassezia. Russian Journal of Clinical Dermatology and Venereology. 2020;19(3):366‑372. (In Russ.)
https://doi.org/10.17116/klinderma202019031366

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RELEVANCE

Investigation of the clinical and morphological features of scalp skin in patients with psoriasis, depending on the presence or absence of foci of lesions of the fungi of the genus Malassezia in the skin scales, in order to determine their role in the pathogenesis of the disease, is of great interest and has not been previously carried out.

THE PURPOSE OF THE STUDY

Was to investigate the clinical and morphological features of scalp skin in patients with psoriasis and to determine the role of fungi of the genus Malassezia in the pathogenesis of this disease.

MATERIAL AND METHODS

15 patients with a diagnosis of psoriasis vulgaris with lesions of the scalp were examined. The severity of psoriatic scalp lesions was assessed using PSSI. To identify Malassezia spp. in the skin scales of the lesions, direct microscopy in a KOH solution using Nomarsky optics was used. Identification of malassezia in scales and histological examination of the skin was carried out by studying serial sections of scalp biopsies.

RESULTS

Patients are divided into 2 groups: by the absence (1st, n=5) and the presence (2nd, n=10) of fungi of the genus Malassezia in the scalp scales. Shown, that: 1) the presence of malassezia in the scales of the scalp skin of patients exacerbates the course of psoriasis; 2) the process of atrophy of the sebaceous glands of the scalp in psoriasis is asynchronous; 3) the vital activity of malassezia in the scales of patients of the 2nd group occurs against the background of the rare prevalence of sebaceous glands.

CONCLUSION

The presence of malassezias in the scales of the scalp of patients exacerbates the course of psoriasis. Obviously, for the development of the microbiota of scalp scales in patients with psoriasis, mainly represented by malassezia, the presence of a high secretory activity of the sebaceous glands is not necessary.

Keywords:

clinical and morphological features

Malassezia

light microscopy

scalp

psoriasis

Authors:

Kornisheva V.G.

North-Western State Medical University named after I.I. Mechnikov

Smolina O.A.

North-Western State Medical University named after I.I. Mechnikov

Stepanova A.A.

Bekhterev National Medical Research Center for Psychiatry and Neurology

ORCID: 0000-0002-4029-9401

Avdeenko Y.L.

Kashkin Research Institute of Medical Mycology

Raznatovsky K.I.

North-Western State Medical University named after I.I. Mechnikov

ORCID: 0000-0003-1022-7463

Received:

11.11.2019

Accepted:

07.04.2020

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