Relevance. One of the important factors affecting the development of sexually transmitted infections (STIs) when contact with a source of infection is the condition of the vaginal environment. In foreign studies, the question has repeatedly been raised about the ability of various disorders of the normal microbiota of the vagina (DNMV) to increase the risk of infection by pathogenic and conditionally pathogenic microorganisms by reducing the activity of the protective mechanisms of lactobacilli. In Russian studies, this issue has not been studied enough and requires further consideration. Purpose of the study was to investigate the relationship of STIs with various DNMV among women of reproductive age. Material and methods. The study included 51,295 women who underwent a laboratory examination for the presence of the main markers of bacterial vaginosis (BV), aerobic vaginitis, the detection of fungi of the genus Candida and STIs (Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium). Samples from the posterolateral vaults of the vagina were tested by real-time PCR. Results. STIs were detected in 2,168 (4.2%) women. Bacterial vaginosis (BV) was detected in 20.8% of patients, among them in 8.7% of cases concomitant STIs were noted, the prevalence of aerobic microflora (aerobic vaginitis) was detected in 4.5% of women, including 2.9% of patients with STIs, an intermediate state microflora — in 5.7% and 5.3%, respectively. The causative agents of STIs were found 2.7 times more often in the group of patients with imbalance of the vaginal microbiota, the differences were significant. Conclusion. According to the results of the study, it was found that among women with DNMV, the prevalence of STIs is significantly higher (p<0.001). DNMV increase the likelihood of contracting various STIs. For the prevention of STIs, timely detection and treatment of various DNMV is important.