The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Lvov A.N.
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia
Kornyat M.S.
Moscow Research and Practical Center for Dermatovenereology and Cosmetology, Department of Healthcare, Moscow, Russia
Igoshina A.V.
Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071
Nazarenko A.R.
Moscow Research and Practical Center for Dermatovenereology and Cosmetology, Department of Healthcare, Moscow, Russia
Perspectives in acne therapy: an analytical review (in Russian only)
Journal: Russian Journal of Clinical Dermatology and Venereology. 2019;18(2): 115‑128
Views: 10264
Downloaded: 424
To cite this article:
Lvov AN, Kornyat MS, Igoshina AV, Nazarenko AR. Perspectives in acne therapy: an analytical review (in Russian only). Russian Journal of Clinical Dermatology and Venereology.
2019;18(2):115‑128. (In Russ.)
https://doi.org/10.17116/klinderma201918021115
New data about the role of permanent inflammation in acne pathogenesis determine modern therapeutic goals and significantly expand the number of drugs for the treatment of this chronic skin disease. The main medicines aimed at the key mechanisms of pathogenesis including inflammation were identified considering comprehensive analysis of literature data and own experience. Perspective drugs include biological medicines and "small molecules"; new inhibitors of sebum production (stearoyl-CoA desaturase inhibitor); melanocortin-5 receptor antagonist (olumacostat glasaretil); some drugs in unusual for them topical form (dapsone, cortexolone-17α propionate, minocycline, new topical retinoid trifarotene); new systemic tetracycline derivative (seracycline); other new antibacterial agents with anti-inflammatory activity. The majority of methods described in the article have not been previously used to treat acne and are currently undergoing clinical trials (some drugs have not yet been registered in the Russian Federation, but they are applied abroad). Besides new drugs, features of administration of isotretinoin in an innovative form including low dose mode are presented in the article.
Authors:
Lvov A.N.
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia
Kornyat M.S.
Moscow Research and Practical Center for Dermatovenereology and Cosmetology, Department of Healthcare, Moscow, Russia
Igoshina A.V.
Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071
Nazarenko A.R.
Moscow Research and Practical Center for Dermatovenereology and Cosmetology, Department of Healthcare, Moscow, Russia
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.