Advanced monitoring of the urogenital and dermatological health of patients infected with the human papillomavirus (HPV) is very important. The issues of improving diagnostic and therapeutic techniques used both for timely elimination of the pathogen and prevention of complications are still relevant. Objective. The objective of the study was to optimize diagnostic and therapeutic techniques in patients with HPV infection of the skin or urogenital tract. Material and methods. The infectious status of the skin and urogenital tract was assessed in 203 and 123 patients, respectively, on the basis of clinical, laboratory, and instrumental studies using visualization, colposcopic control, and HPV verification by PCR, including genotyping, microscopic and cultural studies of free, scraping, and bioptic skin samples with confirmation/exclusion of dermatophytes and Candida yeast fungi, as well as standard methods to detect flora and pathogens of sexually transmitted infections (STIs). Immune status was assessed based on blood levels of CD16+, CD3+, CD4+ lymphocytes, and secretory IgA. Results. The paper presents a range of clinical manifestations of HPV infection. Combinations of viral and mycotic infections of the skin and mucous membranes were detected. Therapeutic techniques of administration of Panavir for effective elimination of the pathogen in patients with HPV infection of the skin and mucous membranes are provided. Conclusion. The feasibility of expanding the diagnostic pathway in patients with HPV infection of the skin and the lower urogenital tract and efficacy of therapeutic techniques using systemic and topical effect of Panavir are evaluated.