Fixed-dose combination of vitamin D3 analog and glucocorticosteroid betamethasone (calcipotriol 50 mg/kg and betamethasone 0.5 mg/kg) is recommended for daily use in patients with different clinical forms of psoriasis. The main mechanisms of action include proliferation suppression and normalization of keratinocyte differentiation, as well as immunomodulating, anti-inflammatory, and peeling effects, which rapidly eliminate the major signs of dermatosis. Material and methods. The effectiveness of the combination drug (calcipotriol + betamethasone) in the form of gel and ointment was assessed in 118 patients with different clinical forms of psoriasis. Results. The combination therapy proved to be effective when daily used by patients with psoriasis for up to 8 weeks, as well as when used for up to 52 weeks. Conclusions. The convenient dosage scheme (once daily), high effectiveness, several dosage forms, minimal adverse effects, positive effect on quality of life, and pharmaco-economic benefit make this pharmaceutical the first-line drug in treatment of psoriasis with different location.