Overcoming antibiotic resistance in treatment of pyoderma

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The paper focuses on etiopathogenetic features of pyoderma course in children. The high incidence of this disease is caused by such factors as anatomical and functional features of pediatric skin, aggressive impact of the environment, and the microbial properties of Staphylococcus aureus. The clinical manifestations and treatment of staphyloderma in pediatrics are described. Special focus is placed on external therapy of pyoderma with silver-based drugs. The mechanisms of action of silver ions on a bacterial cell are presented. The anti-inflammatory and regeneration effects of silver ions are described. The follow-up of the outcomes of external therapy with 2% silver sulfathiazole in 20 patients (11 boys and 9 girls) aged 8 months to 13 years with pyoderma was performed. The high clinical effectiveness, broad range of antimicrobial activity and safety of Argosulfan cream was demonstrated. Thus, the agent can be also used to treat patients with secondary manifestations of pyoderma caused by atopic dermatitis.

Keywords:

pyoderma

children

Staphylococcus aureus

MRSA

silver ions

2% silver sulfathiazole

Authors:

Tamrazova O.B.

Gosudarstvennyĭ tsentr lazernoĭ meditsiny Federal'nogo i mediko-biologicheskogo agentstva Rossii;
Institut khimicheskoĭ fiziki im. N.I. Sechenova RAN, Moskva

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