HIV-infected patients often have cutaneous and mucosal diseases. They vary from opportunistic infections and inflammatory dermatoses to neoplasms and drug responses. Cutaneous mycoses are the most common infectious manifestations of HIV-associated immune suppression. Objective. To study the etiopathogenetic and clinical features of mycoses of the skin and its appendages. Material and methods. The study group included 83 HIV-infected patients with different CD4 count and viral load levels. Mycoses of the skin and its appendages were diagnosed by clinical examination and mycological analysis. Results. Among 83 HIV-infected patients involved in the study, 55 (66.3%) patients had mycoses of the skin and its appendages. The most common forms of mycosis included oropharyngeal candidosis (69.1%), tinea pedis (49.1%), and onychomycosis (45.5%). Dermatophytes and Candida spp. were predominantly detected in HIV-infected patients. The relationship between the incidence rate of dermatomycoses caused by conditionally pathogenic fungi and the immune status of patients was revealed. Cell-mediated immunodeficiency was associated neither with dermatomycoses caused by dermatophytes nor with vulvovaginal candidosis. Dermatomycoses were mostly represented by typical clinical entities; however, they had an atypical course in immunosuppressed patients. Conclusions. Mycoses of the skin and its appendages are common among patients with HIV (in particular, oropharyngeal candidosis, tinea pedis, and onychomycosis) but may manifest as atypical entities. Cutaneous and mucosal diseases caused by conditionally pathogenic fungi are associated with cell-mediated immunodeficiency.