Introduction. Balanoposthitis is a widespread disease characterized by lesions of the glans and the inner layer of the foreskin of the penis. Incidence of the disease depends on the living standards, organization of the healthcare system, religious affiliations, and other features. Objective. To evaluate the indices of social adaptation in patients with different clinical forms of balanoposthitis. Material and methods. Evaluation of the efficacy of treatment and prevention of relapses of bacterial balanoposthitis based on studying the objective clinical criteria and quality-of-life indices (subjective evaluation of the patient) was performed in 42 patients aged 38-76 years. Clinical, instrumental, microbiological and morphological methods were used to diagnose balanoposthitis. All patients were divided into three groups: Group 1 included 21 patients with candidal balanoposthitis; group 2 included 8 patients with anaerobic balanoposthitis; group 3 included 13 patients with aerobic balanoposthitis. Results and discussion. The results of dynamic observation for 10 months were available for 34 of 42 patients with balanoposthitis. The positive impact of the selected treatment program on the incidence of inflammation recurrence was observed. A significant decrease in the frequency of balanoposthitis recurrence was found in 42.6% of patients. Summary. When analyzing the research results, it should be noted that indices of social adaptation and quality of life in patients with balanoposthitis are affected by disease duration, relapse frequency, form of the disease, risk factors for the development and recurrence of inflammation, as well as treatment methods. Conclusions. Optimization of social adaptation and quality of life of patients with balanoposthitis requires a personalized approach to patient management algorithm, which includes comprehensive assessment of all the components of both physical and mental health, as ewll as adequate selection of treatment methods, including identification and correction of risk factors of the development of disease recurrence.