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Beburishvili A.G.

Volgograd State Medical University

Burchuladze N.Sh.

Volgograd State Medical University

Mikhin V.S.

Volgograd State Medical University

Kitaeva A.V.

Volgograd State Medical University

Mikhin I.V.

Volgograd State Medical University

Prediction and diagnosis of pancreatogenic encephalopathy in patients with destructive pancreatitis

Authors:

Beburishvili A.G., Burchuladze N.Sh., Mikhin V.S., Kitaeva A.V., Mikhin I.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(7): 58‑63

DOI: 10.17116/hirurgia202207158

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Table of contents

PREDICTION AND DIAGNOSIS OF PANCREATOGENIC ENCEPHALOPATHY IN PATIENTS WITH DESTRUCTIVE PANCREATITIS
PREDICTION AND DIAGNOSIS OF PANCREATOGENIC ENCEPHALOPATHY IN PATIENTS WITH DESTRUCTIVE PANCREATITIS

To cite this article:

Beburishvili AG, Burchuladze NSh, Mikhin VS, Kitaeva AV, Mikhin IV. Prediction and diagnosis of pancreatogenic encephalopathy in patients with destructive pancreatitis. Pirogov Russian Journal of Surgery. 2022;(7):58‑63. (In Russ.)
https://doi.org/10.17116/hirurgia202207158

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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OBJECTIVE

To study the literature data on pancreatogenic encephalopathy in patients with destructive pancreatitis.

MATERIAL AND METHODS

Searching for Russian- and English-language literature data was carried out in electronic databases: elibrary, PubMed, the Cochrane Library. We planned a systematic review if studies with evidence level 1 and 2 were available. If these trials were absent, descriptive review was considered.

RESULTS

No studies with evidence level 1 and 2 were found in available literature. Therefore, a descriptive review was carried out. Analysis of primary sources showed that the incidence of pancreatogenic encephalopathy is 9-35% and has no direct correlation with etiology of destructive pancreatitis. Major factors of pathogenesis are high serum enzymes, activation of proinflammatory cytokines and hypoxemia, which are accompanied by damage to myelin sheath of the white matter and cytotoxic brain edema. Clinical manifestation of pancreatogenic encephalopathy occurs within two weeks. Acute onset and various symptoms are typical. Possible laboratory predictors of encephalopathy are persistent hyperglycemia, increased hematocrit, fibrinogen-like protein 2 (FPB-2), proinflammatory cytokines TNF-αand interleukin-1-beta. Pancreatogenic encephalopathy is a factor of unfavorable prognosis of treatment. Mortality in patients with pancreatogenic encephalopathy is 57-70%. Favorable course of pancreatic necrosis is followed by regression of cerebral disorders in most cases while residual cognitive disorders are possible in elderly patients.

CONCLUSION

Pancreatogenic encephalopathy accompanies severe destructive pancreatitis. It is an unfavorable factor for treatment outcomes requiring further research.

Keywords:

pancreatic necrosis
pancreatogenic encephalopathy
prognosis
diagnosis and treatment of pancreatic cerebral insufficiency

Authors:

Beburishvili A.G.

Volgograd State Medical University

Burchuladze N.Sh.

Volgograd State Medical University

Mikhin V.S.

Volgograd State Medical University

Kitaeva A.V.

Volgograd State Medical University

Mikhin I.V.

Volgograd State Medical University

Received:

22.11.2021

Accepted:

20.02.2022

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