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Volkov A.Yu.

Blokhin National Medical Research Center of Oncology

Nered S.N.

Blokhin National Medical Research Center of Oncology

Kozlov N.A.

Blokhin National Medical Research Center of Oncology

Stilidi I.S.

Blokhin National Medical Research Center of Oncology

Arkhiri P.P.

Blokhin National Medical Research Center of Oncology

Antonova E.Yu.

Blokhin National Medical Research Center of Oncology

Privezentsev S.A.

Pletnev City Clinical Hospital

Differentiated surgical approach for retroperitoneal non-organ liposarcoma

Authors:

Volkov A.Yu., Nered S.N., Kozlov N.A., Stilidi I.S., Arkhiri P.P., Antonova E.Yu., Privezentsev S.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2021;(7): 36‑44

DOI: 10.17116/hirurgia202107136

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Table of contents

DIFFERENTIATED SURGICAL APPROACH FOR RETROPERITONEAL NON-ORGAN LIPOSARCOMA
DIFFERENTIATED SURGICAL APPROACH FOR RETROPERITONEAL NON-ORGAN LIPOSARCOMA

To cite this article:

Volkov AYu, Nered SN, Kozlov NA, Stilidi IS, Arkhiri PP, Antonova EYu, Privezentsev SA. Differentiated surgical approach for retroperitoneal non-organ liposarcoma. Pirogov Russian Journal of Surgery. 2021;(7):36‑44. (In Russ.)
https://doi.org/10.17116/hirurgia202107136

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To determine the indications for combined and organ-sparing surgery depending on malignancy grade of retroperitoneal liposarcoma.

MATERIAL AND METHODS

A retrospective study included 190 patients with retroperitoneal liposarcoma. Influence of malignancy grade, lesion of adjacent organs and resection/excision of adjacent organs on the overall and recurrence-free survival was studied. Moreover, we analyzed the issue of kidney-sparing surgery and nephrectomy.

RESULTS

Overall and recurrence-free survival were significantly worse in high grade (G2—3) compared to low-grade tumors (G1) (p=0.0001; log—rank test). Visceral invasion was revealed in 23% of patients with low-grade (G1) tumors and 53% of patients with high-grade (G2-3) neoplasms. Visceral invasion significantly impairs overall and recurrence-free survival in both low grade (G1) and high-grade (G2-3) tumors (p=0.0001; log—rank test). In case of low grade (G1) retroperitoneal liposarcoma, overall and recurrence-free survival was similar after combined surgery without histologically confirmed visceral invasion of liposarcoma and organ—sparing surgery (p=0.006; p=0.053; log-rank test). On the contrary, high grade (G2—3) tumor was followed by significantly better overall and recurrence-free survival after combined surgery without histologically confirmed visceral invasion compared to organ—sparing surgery (p=0.006; p=0.053; log-rank test). Recurrence-free survival was similar after kidney-sparing surgery and nephrectomy among patients with low-grade (G1) tumor (p=0.456; log—rank test). In case of high-grade retroperitoneal liposarcoma (G2-3), recurrence-free survival was significantly worse after kidney-sparing surgery compared to nephrectomy (p=0.039; log-rank test).

CONCLUSION

Surgery is the only potentially radical treatment of patients with retroperitoneal liposarcoma. Organ-sparing including kidney-sparing surgery is advisable for low-grade liposarcoma (G1). On the contrary, organ-sparing surgery impairs long-term results and prognosis in patients with high-grade tumors (G2-3). Combined operations including nephrectomy are justified for high-grade retroperitoneal liposarcoma (G2-3).

Keywords:

retroperitoneal liposarcoma
liposarcoma
aggressive surgery
non-organ retroperitoneal tumors
prognosis
organ-sparing surgery

Authors:

Volkov A.Yu.

Blokhin National Medical Research Center of Oncology

Nered S.N.

Blokhin National Medical Research Center of Oncology

Kozlov N.A.

Blokhin National Medical Research Center of Oncology

Stilidi I.S.

Blokhin National Medical Research Center of Oncology

Arkhiri P.P.

Blokhin National Medical Research Center of Oncology

Antonova E.Yu.

Blokhin National Medical Research Center of Oncology

Privezentsev S.A.

Pletnev City Clinical Hospital

Received:

29.07.2020

Accepted:

30.09.2020

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