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Stepanov I.A.

Irkutsk State Medical University, Irkutsk, Russia

Beloborodov V.A.

Irkutsk State Medical University of the Ministry of Health of Russia, Irkutsk, Russia

Borisov V.E.

Irkutsk State Medical University, Irkutsk, Russia

Aliev M.A.

Irkutsk State Medical University, Krasnogo Vosstaniya Str., 1, Irkutsk, 664003, Russia

Shepelev V.V.

Department of hospital surgery with course of neurosurgery Irkutsk State Medical University, Irkutsk, Russia

Pestryakov Yu.Ya.

Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russia

The effectiveness of local application of vancomycin powder in the prevention of surgical site infections in spine surgery: a meta-analysis

Authors:

Stepanov I.A., Beloborodov V.A., Borisov V.E., Aliev M.A., Shepelev V.V., Pestryakov Yu.Ya.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(6): 60‑70

DOI: 10.17116/hirurgia202006160

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Table of contents

THE EFFECTIVENESS OF LOCAL APPLICATION OF VANCOMYCIN POWDER IN THE PREVENTION OF SURGICAL SITE INFECTIONS IN SPINE SURGERY: A META-ANALYSIS
THE EFFECTIVENESS OF LOCAL APPLICATION OF VANCOMYCIN POWDER IN THE PREVENTION OF SURGICAL SITE INFECTIONS IN SPINE SURGERY: A META-ANALYSIS

To cite this article:

Stepanov IA, Beloborodov VA, Borisov VE, Aliev MA, Shepelev VV, Pestryakov YuYa. The effectiveness of local application of vancomycin powder in the prevention of surgical site infections in spine surgery: a meta-analysis. Pirogov Russian Journal of Surgery. 2020;(6):60‑70. (In Russ.)
https://doi.org/10.17116/hirurgia202006160

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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Objective. To perform a meta-analysis of studies examining the effectiveness of the local application of vancomycin powder for the prophylaxis of surgical site infections (SSIs) in spine surgery. Material and methods. Retrospective cohort studies and prospective randomized clinical trials were searched for in the Pubmed, EMBASE, Cochrane Library and eLibrary databases published from 2008 to December 2018. For the resulting variables, the odds ratio and 95% confidence interval were calculated using random and fixed effects models. Estimation of the degree of heterogeneity is estimated using the coefficient I2. Statistically significant differences were considered differences p<0.05. Results. The meta-analysis included 28 clinical studies that included the results of the local application of vancomycin powder in 17,469 patients after performing various spinal surgical interventions. Two publications had a prospective, randomized, controlled study design. Topical application of vancomycin powder reduces the incidence of SSIs after spine surgery (p<0.0001). The use of vancomycin powder reduces the incidence of SSIs in patients operated on with stabilizing implants (p=0.004). On the other hand, the topical application of vancomycin powder did not affect the prevalence of SSIs in respondents who were operated on without the use of stabilizing implants (p=0.12) or due to deformities of the spine (p=0.06). Conclusion. Topical application of vancomycin powder is highly effective in preventing the development of SSIs in patients after spinal surgical interventions.

Keywords:

spine surgery
surgical site infections
vancomycin powder
local application
prophylaxis

Authors:

Stepanov I.A.

Irkutsk State Medical University, Irkutsk, Russia

Beloborodov V.A.

Irkutsk State Medical University of the Ministry of Health of Russia, Irkutsk, Russia

Borisov V.E.

Irkutsk State Medical University, Irkutsk, Russia

Aliev M.A.

Irkutsk State Medical University, Krasnogo Vosstaniya Str., 1, Irkutsk, 664003, Russia

Shepelev V.V.

Department of hospital surgery with course of neurosurgery Irkutsk State Medical University, Irkutsk, Russia

Pestryakov Yu.Ya.

Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russia

List of references:

  1. Byvaltsev VA, Stepanov IA, Borisov VE, Kalinin AA, Pleshko IV, Belykh EG, et al. Surgical site infections in spinal neurosurgery. 2017;98(5):796-803. (In Russ.)
  2. Cotogni P, Barbero C, Passera R, Fossati L, Olivero G, Rinaldi M. Violation of prophylactic vancomycin administration timing is a potential risk factor for rate of surgical site infections in cardiac surgery patients: a prospective cohort study. . 2017;17(1):73. 
  3. Patel H, Khoury H, Girgenti D, Welner S, Yu H. Burden of Surgical Site Infections Associated with Select Spine Operations and Involvement of Staphylococcus aureus. 2017;18(4):461-473.
  4. Nota SP, Braun Y, Ring D, Schwab JH. Incidence of surgical site infection after spine surgery: what is the impact of the definition of infection? 2014;473(5):1612-1619.
  5. West JM, Jordan SW, Mendel E, Khan SN, Chandawarkar RY, Valerio IL. Instillation Negative Pressure Wound Therapy: An Effective Tool for Complex Spine Wounds. 2018;7(10):333-338.
  6. Ogihara S, Yamazaki T, Inanami H, et al. Risk factors for surgical site infection after lumbar laminectomy and/or discectomy for degenerative diseases in adults: A prospective multicenter surveillance study with registry of 4027 cases. 2018;13(10):e0205539. Published 2018 Oct 16. 
  7. Rosenthal NA, Heinrich KH, Chung J, Yu H. Cost and Hospital Resource Utilization of Staphylococcus aureus Infection Post Elective Posterior Instrumented Spinal Fusion Surgeries in U.S. Hospitals: A Retrospective Cohort Study. 2018 Oct 15. 
  8. Dessy AM, Yuk FJ, Maniya AY, et al. Reduced Surgical Site Infection Rates Following Spine Surgery Using an Enhanced Prophylaxis Protocol. 2017;9(4):e1139. Published 2017 Apr 6. 
  9. Chahoud J, Kanafani Z, Kanj SS. Surgical site infections following spine surgery: eliminating the controversies in the diagnosis. 2014;1:7. Published 2014 Mar 24. 
  10. Anderson PA, Savage JW, Vaccaro AR, Radcliff K, Arnold PM, Lawrence BD, et al. Prevention of Surgical Site Infection in Spine Surgery. Neurosurgery. 2017 Mar 1;80(3S):S114-S123.
  11. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. . 2009;62(10):1-34. 
  12. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? 1996;17(1): 1-12.
  13. Margulis AV, Pladevall M, Riera-Guardia N, et al. Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: the Newcastle-Ottawa Scale and the RTI item bank. 2014;6:359-368. 
  14. Belykh E, Carotenuto A, Kalinin AA, Akshulakov SK, Kerimbayev T, Borisov VE, et al. Surgical protocol for infections, nonhealing wound prophylaxis, and analgesia: development and implementation for posterior spinal fusions. 2018 Nov 24. pii: S1878-8750(18)32694-9. 
  15. Cannon JGD, Ho AL, Mohole J, et al. Topical vancomycin for surgical prophylaxis in non-instrumented pediatric spinal surgeries. 2018;5:1-5. 
  16. Caroom C, Tullar JM, Benton EG Jr, Jones JR, Chaput CD. Intrawound vancomycin powder reduces surgical site infections in posterior cervical fusion. 2013;38(14):1183-1187.
  17. Dennis HW, Thiam DW, Koh ZS, et al. Is Intraoperative Local Vancomycin Powder the Answer to Surgical Site Infections in Spine Surgery? 2017;42(4):267-274. 
  18. Devin CJ, Chotai S, McGirt MJ, et al. Intrawound vancomycin decreases the risk of surgical site infection after posterior spine surgery: a multicenter analysis. 2018;43(1):65-71. 
  19. Emohare O, Ledonio CG, Hill BW, Davis RA, Polly DW Jr, Kang MM. Cost savings analysis of intrawound vancomycin powder in posterior spinal surgery. 2014;14(11):2710-2715.
  20. Feng T, Yang Y. Effects observation of local intrawound application vancomycin in prevention surgical site infection after the spine surgeries. 2018;21(2):157-159. 
  21. Garg S, Bloch N, Potter M, et al. Topical vancomycin in pediatric spine surgery does not reduce surgical site infection: a retrospective cohort study. 2018;6(5):523-528. 
  22. Godil SS, Parker SL, O’Neill KR, Devin CJ, McGirt MJ. Comparative effectiveness and cost-benefit analysis of local application of vancomycin powder in posterior spinal fusion for spine trauma: clinical article. 2013;19(3):331-335. 
  23. Haimoto S, Schär RT, Nishimura Y, Hara M, Wakabayashi T, Ginsberg HJ. Reduction in surgical site infection with suprafascial intrawound application of vancomycin powder in instrumented posterior spinal fusion: a retrospective case-control study. 2018;29(2):193-198. 
  24. Heller A, McIff TE, Lai SM, Burton DC. Intrawound vancomycin powder decreases staphylococcal surgical site infections after posterior instrumented spinal arthrodesis. 2015;28(10): E584-E589.
  25. Hida T, Ando K, Kobayashi K, Ito K, Tsushima M, Matsumoto A, et al. Intrawound Vancomycin powder as the prophylaxis of surgical site infection after invasive spine surgery with a high risk of infection. 2017;79(4):545-550. 
  26. Hill BW, Emohare O, Song B, Davis R, Kang MM. The use of vancomycin powder reduces surgical reoperation in posterior instrumented and noninstrumented spinal surgery. 2014;156(4):749-754. 
  27. Horii C, Yamazaki T, Oka H, et al. Does intrawound vancomycin powder reduce surgical site infection after posterior instrumented spinal surgery? A propensity score-matched analysis. Epub 2018 Apr 26. 
  28. Kim HS, Lee SG, Kim WK, Park CW, Son S. Prophylactic intrawound application of vancomycin powder in instrumented spinal fusion surgery. 2013;10(3):121-125. 
  29. Li XC, Qin Y, Xuxuan W, Wang XX. The effect of local application of vancomycin powder after posterior lumbar interbody fusion surgery on prevention of surgical site infection and fusion rate. 2016;26(12):1109-1114.
  30. Martin JR, Adogwa O, Brown CR, et al. Experience with intrawound vancomycin powder for spinal deformity surgery. 2014;39(2):177-184. 
  31. Martin JR, Adogwa O, Brown CR, et al. Experience with intrawound vancomycin powder for posterior cervical fusion surgery. 2015;22(1):26-33. 
  32. Mirzashahi B, Chehrassan M, Mortazavi SMJ. Intrawound application of vancomycin changes the responsible germ in elective spine surgery without significant effect on the rate of infection: a randomized prospective study. 2018;102(1):35-39. 
  33. O’Neill KR, Smith JG, Abtahi AM, et al. Reduced surgical site infections in patients undergoing posterior spinal stabilization of traumatic injuries using vancomycin powder. 2011;11(7):641-646. 
  34. Pahys JM, Pahys JR, Cho SK, Kang MM, Zebala LP, Hawasli AH, et al. Methods to decrease postoperative infections following posterior cervical spine surgery. 2013;95(6):549-554. 
  35. Strom RG, Pacione D, Kalhorn SP, Frempong-Boadu AK. Lumbar laminectomy and fusion with routine local application of vancomycin powder: decreased infection rate in instrumented and non-instrumented cases. 2013;115(9):1766-1769.
  36. Strom RG, Pacione D, Kalhorn SP, Frempong-Boadu AK. Decreased risk of wound infection after posterior cervical fusion with routine local application of vancomycin powder. . 2013;38(12):991-994. 
  37. Sweet FA, Roh M, Sliva C. Intrawound application of vancomycin for prophylaxis in instrumented thoracolumbar fusions: efficacy, drug levels, and patient outcomes. 2011;36(24):2084-2088.
  38. Theologis AA, Demirkiran G, Callahan M, Pekmezci M, Ames C, Deviren V. Local intrawound vancomycin powder decreases the risk of surgical site infections in complex adult deformity reconstruction: a cost analysis. . 2014;39(22):1875-1880.
  39. Thompson GH, Poe-Kochert C, Hardesty CK, Son-Hing J, Mistovich RJ. Does Vancomycin Powder Decrease Surgical Site Infections in Growing Spine Surgery? A Preliminary Study. 2018;100(6):466-471. 
  40. Tomov M, Mitsunaga L, Durbin-Johnson B, Nallur D, Roberto R. Reducing surgical site infection in spinal surgery with betadine irrigation and intrawound vancomycin powder. 2015;40(7):491-499. 
  41. Tubaki VR, Rajasekaran S, Shetty AP. Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients. 2013;38(25):2149-2155.
  42. Texakalidis P, Lu VM, Yolcu Y, Kerezoudis P, Alvi MA, Parney IF, et al. Impact of Powdered Vancomycin on Preventing Surgical Site Infections in Neurosurgery: A Systematic Review and Meta-analysis. 2018.
  43. Peng XQ, Sun CG, Fei ZG, Zhou QJ. Risk Factors for Surgical Site Infection after Spinal Surgery: A Systematic Review and Meta-Analysis Based on Twenty-Seven Studies. pii: S1878-8750(18)32717-7. 
  44. Saleh A, Khanna A, Chagin KM, Klika AK, Johnston D, Barsoum WK. Glycopeptides versus β-lactams for the prevention of surgical site infections in cardiovascular and orthopedic surgery: a meta-analysis. 2015;261(1):72-80. 
  45. Evaniew N, Khan M, Drew B, Peterson D, Bhandari M, Ghert M. Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis. 2015;24(3):533–542. 
  46. Byvaltsev VA, Stepanov IA, Borisov VE. Adverse drug reactions to local intrawound vancomycin application after posterior lumbosacral fusion. . 2018;15(2):76-83. (In Russ.)
  47. Tailaiti A, Shang J, Shan S, Muheremu A. Effect of intrawound vancomycin application in spinal surgery on the incidence of surgical site infection: a meta-analysis. 2018;14:2149-2159.
  48. De Lissovoy G, Fraeman K, Hutchins V, Murphy D, Song D, Vaughn BB. Surgical site infection: incidence and impact on hospital utilization and treatmentncosts. 2009;37(5):387-397. 

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