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Stepanov I.A.

Irkutsk State Medical University, Irkutsk, Russia

Beloborodov V.A.

Irkutsk State Medical University of the Ministry of Health of Russia, Irkutsk, Russia

Borisov V.E.

Irkutsk State Medical University, Irkutsk, Russia

Aliev M.A.

Irkutsk State Medical University, Krasnogo Vosstaniya Str., 1, Irkutsk, 664003, Russia

Shepelev V.V.

Department of hospital surgery with course of neurosurgery Irkutsk State Medical University, Irkutsk, Russia

Pestryakov Yu.Ya.

Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russia

The effectiveness of local application of vancomycin powder in the prevention of surgical site infections in spine surgery: a meta-analysis

Authors:

Stepanov I.A., Beloborodov V.A., Borisov V.E., Aliev M.A., Shepelev V.V., Pestryakov Yu.Ya.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(6): 60‑70

DOI: 10.17116/hirurgia202006160

Views: 731

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To cite this article:

Stepanov IA, Beloborodov VA, Borisov VE, Aliev MA, Shepelev VV, Pestryakov YuYa. The effectiveness of local application of vancomycin powder in the prevention of surgical site infections in spine surgery: a meta-analysis. Pirogov Russian Journal of Surgery. 2020;(6):60‑70. (In Russ.)
https://doi.org/10.17116/hirurgia202006160

Подписка 2025 (Pirogov Russian Journal of Surgery)
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Objective. To perform a meta-analysis of studies examining the effectiveness of the local application of vancomycin powder for the prophylaxis of surgical site infections (SSIs) in spine surgery. Material and methods. Retrospective cohort studies and prospective randomized clinical trials were searched for in the Pubmed, EMBASE, Cochrane Library and eLibrary databases published from 2008 to December 2018. For the resulting variables, the odds ratio and 95% confidence interval were calculated using random and fixed effects models. Estimation of the degree of heterogeneity is estimated using the coefficient I2. Statistically significant differences were considered differences p<0.05. Results. The meta-analysis included 28 clinical studies that included the results of the local application of vancomycin powder in 17,469 patients after performing various spinal surgical interventions. Two publications had a prospective, randomized, controlled study design. Topical application of vancomycin powder reduces the incidence of SSIs after spine surgery (p<0.0001). The use of vancomycin powder reduces the incidence of SSIs in patients operated on with stabilizing implants (p=0.004). On the other hand, the topical application of vancomycin powder did not affect the prevalence of SSIs in respondents who were operated on without the use of stabilizing implants (p=0.12) or due to deformities of the spine (p=0.06). Conclusion. Topical application of vancomycin powder is highly effective in preventing the development of SSIs in patients after spinal surgical interventions.

Keywords:

spine surgery
surgical site infections
vancomycin powder
local application
prophylaxis

Authors:

Stepanov I.A.

Irkutsk State Medical University, Irkutsk, Russia

Beloborodov V.A.

Irkutsk State Medical University of the Ministry of Health of Russia, Irkutsk, Russia

Borisov V.E.

Irkutsk State Medical University, Irkutsk, Russia

Aliev M.A.

Irkutsk State Medical University, Krasnogo Vosstaniya Str., 1, Irkutsk, 664003, Russia

Shepelev V.V.

Department of hospital surgery with course of neurosurgery Irkutsk State Medical University, Irkutsk, Russia

Pestryakov Yu.Ya.

Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russia

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