Analysis of endothelial dysfunction in the context of pleural effusions of various origins using skin thermometry

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OBJECTIVE

To analyze the mechanisms and severity of endothelial dysfunction in patients with pleural effusion of various origins using skin thermometry.

MATERIAL AND METHODS

We studied microcirculation in 135 patients with pleural effusions of various origins. Local skin thermometry and computer wavelet analysis were performed in 3-5 days after thoracoscopy with pleural biopsy using Microtest-100WF device with a temperature measuring resolution of 0.001°C. We estimated endothelial, myogenic and neurogenic indices using spectral analysis of skin temperature fluctuations in a range 0.0095-2 Hz. The control group comprised 40 healthy participants aged 23-36 years.

RESULTS

Three groups of patients were distinguished depending on the cause of effusion: malignant pleural effusions (n=65, 48.1%); inflammatory pleural effusions (para-pneumonic, post-traumatic, pancreatogenic, tuberculous) (n=58, 43%); transudates (hepatogenic, cardiogenic, and nephrogenic) (n=12, 8.9%). There were no significant differences in vascular tone in response to local heating of the second finger of the hand up to 40°C. Measurements were carried out within 10 min in all groups. Patients with diabetes mellitus and cardiovascular diseases (n=48, 35.6%) had significant decrease of thermal vasodilation index in endothelial range up to 2.93±1.77, in the control group — up to 4.21±2.40 (p=0.041).

CONCLUSION

Endothelial dysfunction is a universal non-specific aspect in pathogenesis of various diseases. This process is essential in pleural effusion. Local thermometry and computer wavelet analysis revealed no significant differences between patients with malignant, inflammatory and transudative pleural effusions. Pleural effusions in the context of cardiovascular pathology and/or diabetes mellitus occur due to impaired vasodilatation mechanisms in endothelial range.

Keywords:

pleural effusion

pleuritis

endothelial dysfunction

skin thermometry

heating test

Authors:

Plaksin S.A.

Vagner Perm State Medical University

ORCID: 0000-0001-8108-1655

Farshatova L.I.

Vagner Perm State Medical University

Received:

19.01.2020

Accepted:

21.02.2020

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