Liver regeneration: solved and problem issues

Plekhanov A.N.; Tovarshinov A.I.

doi:https://doi.org/10.17116/hirurgia2020111101

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Abstract:

It is known that liver is able to restore own dimensions and functional properties in response to various injuries. Despite extensive injuries, liver can preserve functional activity. Analysis of liver regeneration mechanisms allowed us to obtain significant results in the treatment of hepatitis, cirrhosis and liver failure. Liver regeneration processes substantiate the development of hepatocellular cancer following cirrhosis. Modern experimental and clinical data on liver regeneration, as well as current methods of stimulating this process are summarized in the manuscript. Despite significant advances in this issue, there are still many questions in scientific understanding of liver regeneration.

Keywords:

liver

regeneration

mechanisms

regulation

stem cells

Authors:

Plekhanov A.N.

Dorzhi Banzarov Buryat State University;
Irkutsk Research Center for Surgery and Traumatology

ORCID: 0000-0002-2939-8863

Tovarshinov A.I.

Dorzhi Banzarov Buryat State University

ORCID: 0000-0003-1909-8047

Received:

23.10.2019

Accepted:

11.11.2019

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References:

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