The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II

Vinnik Yu.S.; Salmina A.B.; Tepliakova O.V.; Drobushevskaia A.I.; Pozhilenkova E.A.; Morgun A.V.; Shapran M.V.; Kovalenko A.O.

doi:https://doi.org/10.17116/hirurgia2015263-69

Vinnik Yu.S.

Krasnoyarsk State Medical University. prof. V.F Voyno-Yasenetsky, Krasnoyarsk, Russia;
Clinical Hospital №7, Krasnoyarsk, Russia

Salmina A.B.

Kafedra biologicheskoĭ khimii s kursami meditsinskoĭ farmatsevticheskoĭ i toksikologicheskoĭ khimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo, NII molekuliarnoĭ meditsiny i patobiokhimii, Krasnoiarsk

Tepliakova O.V.

Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo

Drobushevskaia A.I.

Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo

Pozhilenkova E.A.

Morgun A.V.

Kafedra biokhimii s kursami meditsinskoĭ, farmatsevticheskoĭ i toksikologicheskoĭ khimii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo

Shapran M.V.

Institut poliklinicheskoĭ meditsiny, Krasnoiarsk

Kovalenko A.O.

Institut poliklinicheskoĭ meditsiny, Krasnoiarsk

The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II

Authors:

Vinnik Yu.S., Salmina A.B., Tepliakova O.V., Drobushevskaia A.I., Pozhilenkova E.A., Morgun A.V., Shapran M.V., Kovalenko A.O.

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Journal: Pirogov Russian Journal of Surgery. 2015;(2): 63‑69

DOI: 10.17116/hirurgia2015263-69

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To cite this article:

Vinnik YuS, Salmina AB, Tepliakova OV, et al. . The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II. Pirogov Russian Journal of Surgery. 2015;(2):63‑69. (In Russ.)
https://doi.org/10.17116/hirurgia2015263-69

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

Levels of interleukins-6, 8, 10, TNF-alpha and basic fibroblast growth factor (bFGF) were examined in peripheral blood of 60 patients with diabetes mellitus type II and soft tissues infections. It was revealed the elevated levels of proinflammatory (IL-6, 8), anti-inflammatory (IL-10) cytokines and basic fibroblast growth factor at the time of admission. Application of combined ozone therapy including ozonated autohemotherapy and superficial management of wounds with ozone-oxygen mixture resulted in significant decrease of IL-6, 8, 10 production and high level of bFGF on blood serum. Thus effective local bactericidal impact of ozone in combination with normalization of proinflammatory cytokines levels and preserved high level of bFGF in peripheral blood provide better results of wound healing process in patients with diabetes mellitus type II.

Keywords:

soft tissues infections

diabetes mellitus type II

cytokines

interleukins

ozone therapy

basic fibroblast growth factor

Authors:

Vinnik Yu.S.

Krasnoyarsk State Medical University. prof. V.F Voyno-Yasenetsky, Krasnoyarsk, Russia;
Clinical Hospital №7, Krasnoyarsk, Russia

Salmina A.B.

Tepliakova O.V.

Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo

Drobushevskaia A.I.

Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo

Pozhilenkova E.A.

Morgun A.V.

Shapran M.V.

Institut poliklinicheskoĭ meditsiny, Krasnoiarsk

Kovalenko A.O.

Institut poliklinicheskoĭ meditsiny, Krasnoiarsk

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References:

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