The method of pancreaticojejunostomy in pancreaticoduodenectomy was applied in 20 patients. The technique is based on the first row of through P-shaped sutures in the sequence of jejunum-pancreas-jejunum. This method excludes thread pressure on pancreatic tissue. The technique may be used in any pancreatic texture. Pancreaticojejunostomy failure was observed in 2 patients (10%). The complication was not determined by pancreatic anastomotic technique in 1 case. There were 2 deaths (10%). The causes of lethal outcomes were not determined by peculiarities of pancreaticojejunostomy performing. The obtained results show good preventive properties of proposed method relatively pancreaticojejunostomy failure and postoperative pancreatitis.