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Malinovskaya L.K.

Sechenov First Moscow State Medical University

Chomakhidze P.Sh.

Sechenov First Moscow State Medical University

Bykova A.A.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Shaltaeva Yu.R.

National Research Nuclear University MEPhI, Moscow, Russia

Belyakov V.V.

National Research Nuclear University MEPhI, Moscow, Russia

Golovin A.V.

National Research Nuclear University MEPhI, Moscow, Russia

Pershenkov V.S.

National Research Nuclear University MEPhI, Moscow, Russia

Syrkin A.L.

Sechenov First Moscow State Medical University

Betelin V.B.

Scientific Research Institute for System Analysis of the Russian Academy of Sciences, Moscow, Russia

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

Proton transfer reaction mass spectrometry of exhaled breath in diagnosis of heart failure with preserved ejection fraction

Authors:

Malinovskaya L.K., Chomakhidze P.Sh., Bykova A.A., Shaltaeva Yu.R., Belyakov V.V., Golovin A.V., Pershenkov V.S., Syrkin A.L., Betelin V.B., Kopylov F.Iu.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2018;11(6): 45‑51

DOI: 10.17116/kardio20181106145

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Table of contents

PROTON TRANSFER REACTION MASS SPECTROMETRY OF EXHALED BREATH IN DIAGNOSIS OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
PROTON TRANSFER REACTION MASS SPECTROMETRY OF EXHALED BREATH IN DIAGNOSIS OF HEART FAILURE WITH PRESERVED EJECTION FRACTION

To cite this article:

Malinovskaya LK, Chomakhidze PSh, Bykova AA, et al. . Proton transfer reaction mass spectrometry of exhaled breath in diagnosis of heart failure with preserved ejection fraction. Russian Journal of Cardiology and Cardiovascular Surgery. 2018;11(6):45‑51. (In Russ.)
https://doi.org/10.17116/kardio20181106145

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Abstract Aim — to evaluate diagnostic role of proton transfer reaction mass spectrometry for chronic heart failure (CHF) with preserved ejection fraction (EF). Material and methods. There were 38 patients with signs of CHF and normal left ventricular ejection (>50%) for the period from October 2014 to April 2016. All patients underwent proton transfer reaction mass spectrometry of exhaled breath and blood copeptin level determination. The diagnosis of CHF was verified by determining N-terminal prohormone of brain natriuretic peptide (NT-proBNP). Diagnosis of CHF was not confirmed in 13 out of 38 patients. Results. It was found that incidence of atrial fibrillation (p=0.034), levels of copeptin (p=0.014) and acetone in exhaled breath (p=0.023) were significantly higher in patients with CHF. There was also a reliable correlation between acetone concentration in exhaled breath and NT-proBNP, pulmonary artery pressure and copeptine. Conclusion. Acetone in exhaled breath may be a promising non-invasive method of diagnosis of heart failure with preserved ejection fraction.

Keywords:

brain natriuretic peptide
exhaled breath acetone
copeptine
chronic heart failure
proton transfer reaction mass spectrometry

Authors:

Malinovskaya L.K.

Sechenov First Moscow State Medical University

Chomakhidze P.Sh.

Sechenov First Moscow State Medical University

Bykova A.A.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Shaltaeva Yu.R.

National Research Nuclear University MEPhI, Moscow, Russia

Belyakov V.V.

National Research Nuclear University MEPhI, Moscow, Russia

Golovin A.V.

National Research Nuclear University MEPhI, Moscow, Russia

Pershenkov V.S.

National Research Nuclear University MEPhI, Moscow, Russia

Syrkin A.L.

Sechenov First Moscow State Medical University

Betelin V.B.

Scientific Research Institute for System Analysis of the Russian Academy of Sciences, Moscow, Russia

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

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  3. Owan TE, Hodge DO, Herges RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355(3):251-259. https://doi.org/10.1056/NEJMoa052256
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