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Malinovskaya L.K.

Sechenov First Moscow State Medical University

Chomakhidze P.Sh.

Sechenov First Moscow State Medical University

Bykova A.A.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Shaltaeva Yu.R.

National Research Nuclear University MEPhI, Moscow, Russia

Belyakov V.V.

National Research Nuclear University MEPhI, Moscow, Russia

Golovin A.V.

National Research Nuclear University MEPhI, Moscow, Russia

Pershenkov V.S.

National Research Nuclear University MEPhI, Moscow, Russia

Syrkin A.L.

Sechenov First Moscow State Medical University

Betelin V.B.

Scientific Research Institute for System Analysis of the Russian Academy of Sciences, Moscow, Russia

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

Proton transfer reaction mass spectrometry of exhaled breath in diagnosis of heart failure with preserved ejection fraction

Authors:

Malinovskaya L.K., Chomakhidze P.Sh., Bykova A.A., Shaltaeva Yu.R., Belyakov V.V., Golovin A.V., Pershenkov V.S., Syrkin A.L., Betelin V.B., Kopylov F.Iu.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2018;11(6): 45‑51

DOI: 10.17116/kardio20181106145

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Table of contents

PROTON TRANSFER REACTION MASS SPECTROMETRY OF EXHALED BREATH IN DIAGNOSIS OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
PROTON TRANSFER REACTION MASS SPECTROMETRY OF EXHALED BREATH IN DIAGNOSIS OF HEART FAILURE WITH PRESERVED EJECTION FRACTION

To cite this article:

Malinovskaya LK, Chomakhidze PSh, Bykova AA, et al. . Proton transfer reaction mass spectrometry of exhaled breath in diagnosis of heart failure with preserved ejection fraction. Russian Journal of Cardiology and Cardiovascular Surgery. 2018;11(6):45‑51. (In Russ.)
https://doi.org/10.17116/kardio20181106145

 
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Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Abstract:

Abstract Aim — to evaluate diagnostic role of proton transfer reaction mass spectrometry for chronic heart failure (CHF) with preserved ejection fraction (EF). Material and methods. There were 38 patients with signs of CHF and normal left ventricular ejection (>50%) for the period from October 2014 to April 2016. All patients underwent proton transfer reaction mass spectrometry of exhaled breath and blood copeptin level determination. The diagnosis of CHF was verified by determining N-terminal prohormone of brain natriuretic peptide (NT-proBNP). Diagnosis of CHF was not confirmed in 13 out of 38 patients. Results. It was found that incidence of atrial fibrillation (p=0.034), levels of copeptin (p=0.014) and acetone in exhaled breath (p=0.023) were significantly higher in patients with CHF. There was also a reliable correlation between acetone concentration in exhaled breath and NT-proBNP, pulmonary artery pressure and copeptine. Conclusion. Acetone in exhaled breath may be a promising non-invasive method of diagnosis of heart failure with preserved ejection fraction.

Keywords:

brain natriuretic peptide
exhaled breath acetone
copeptine
chronic heart failure
proton transfer reaction mass spectrometry

Authors:

Malinovskaya L.K.

Sechenov First Moscow State Medical University

Chomakhidze P.Sh.

Sechenov First Moscow State Medical University

Bykova A.A.

GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova"

Shaltaeva Yu.R.

National Research Nuclear University MEPhI, Moscow, Russia

Belyakov V.V.

National Research Nuclear University MEPhI, Moscow, Russia

Golovin A.V.

National Research Nuclear University MEPhI, Moscow, Russia

Pershenkov V.S.

National Research Nuclear University MEPhI, Moscow, Russia

Syrkin A.L.

Sechenov First Moscow State Medical University

Betelin V.B.

Scientific Research Institute for System Analysis of the Russian Academy of Sciences, Moscow, Russia

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

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References:

  1. Cleland JG, Swedberg K, Follath F, et al. The EuroHeart Failure survey programme a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J. 2003;24(5):442-463. https://doi.org/10.1016/S0195-668X902)00823-0
  2. Mareev VYu, Danielyan MO, Belenkov YuN. On behalf of the working group research on the EPOCH–O–CHF. Comparative characteristics of patients with CHF, depending on the value of EV on the results of the Russian multicenter study EPOCH –O–CHF. Heart Failure. 2006;7(4):164-171. (In Russ)
  3. Owan TE, Hodge DO, Herges RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355(3):251-259. https://doi.org/10.1056/NEJMoa052256
  4. Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF. Braunwald’s Heart Disease: a textbook of cardiovascular medicine. Single Vol., 11th ed 523-543 ISBN: 978-0-323-46299-0
  5. Fazulina KS, Fomin VV, Meshalkina VV. Predictive significance of disturbed water-salt homeostasis in decompensated chronic heart failure patients. Kardiologiia. 2018 Apr;S4:10-21. (In Russ) https://doi.org/10.1373/clinchem.2017.278705
  6. Lindinger W, Hansel A, Jordan A. On-line monitoring of volatile organic compounds at pptv levels by means of Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS): Medical applications, food control and environmental research. Int J Mass Spectrom. 1998 February;173(3):191-241. https://doi.org/10.1016/S0168-1176(97)00281-4
  7. Cikach FSJr, Dweik RA. Cardiovascular Biomarkers In Exhaled Breath. Prog Cardiovasc Dis. 2012;55(1):34-43. https://doi.org/10.1016/j.pcad.2012.05.005
  8. Kopylov FYu, Syrkin AL, Chomakhidze PSh, et al. Proton Transfer Reaction Mass Spectrometry of Exhaled Breath in Diagnostics of Heart Failure. Kardiologiya. 2016;56(5):37-41. https://doi.org/10.18565/cardio.2016.5.37-41
  9. Marcondes-Braga FG, Batista GL, Bacal F, et al. Exhaled Breath Analysis in Heart Failure. Curr Heart Fail Rep. 2016 Aug;13(4):166-171. https://doi.org/10.1007/s11897-016-0294-8
  10. Marcondes-Braga FG, Batista GL, Gutz IGR, et al. Impact of Exhaled Breath Acetone in the Prognosis of Patients with Heart Failure with Reduced Ejection Fraction (HFrEF). One Year of Clinical Follow-up. 2016 December 28. https://doi.org/10.1371/journal.pone.0168790
  11. Balling L, Gustafsson F. Copeptin as a biomarker in heart failure. Biomark Med. 2014;8(6):841-854. https://doi.org/10.2217/bmm.14.50
  12. Burnasheva GA, Napalkov DA. Natriuretic Peptides: Role in Current Cardiology. Vestn Ross Akad Med Nauk. 2015;70(5):568-572. https://doi.org/10.15690/vramn.v70.i5.1443
  13. Amann A, Poupart G, Telser S, et al. Applications of breath gas analysis in medicine. Int J Mass Spectrom. 2004 15 December;239:Issues 2-3:227-233. https://doi.org/10.1016/j.ijms.2004.08.010
  14. Stoiser B, Mortl D, Hulsmann M, et al. Copeptin, a fragment of the vasopressin precursor, as a novel predictor of outcome in heart failure. Eur J Clin Invest. 2006;36:771-778. https://doi.org/10.1111/j.1365-2362.2006.01724.x
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