Aim — to evaluate an effectiveness of heart mobilization in transaortic septal myectomy. Material and methods. The study included 132 patients with hypertrophic cardiomyopathy (HCM) who were operated in the Almazov National Medical Research Centre in 2011—2017. All patients underwent transaortic myectomy of interventricular septum (IVS). Heart mobilization was used in 39 (29.5%) cases. In 38 (28.8%) cases intersection of superior vena cava (SVC) was carried out; procedure was supplemented by left atrial dissection in 13 (34.2%) of them; Guiraudon approach was applied in 1 (2,6%) case. Results. There were significant differences in the incidence of redo aortic cross-clamping for additional myectomy and excised myocardial mass. Heart mobilization was followed by adequate myectomy and larger myocardial mass excised in all cases. Time of cardiopulmonary bypass (CPB) and aortic cross-clamping was significantly higher in group of heart mobilization. However, redo aortic cross-clamping was associated with 2-fold increase of these values. In-hospital mortality, intraoperative and postoperative blood loss, ICU-stay, mitral insufficiency grade, left ventricular outflow tract pressure gradient, thickness of IVS after surgery, incidence of intraventricular and atrioventricular blocks were similar in both groups. Conclusion. Heart mobilization during septal myectomy improves surgical quality in some patients, prevents redo aortic cross-clamping and increases excising myocardial mass. CPB and aortic cross-clamping time is significantly less in case of heart mobilization compared with redo cross-clamping. Procedure is not accompanied by advanced morbidity and prolonged ICU-stay.