Aim. To study the antioxidant activity Cytoflavin in acute myocardial infarction. Material and methods. 46 patients with standard therapy received the drug cytoflavin (POLYSAN, St. Petersburg, Russia) intravenously 20 ml of the solution diluted in 250 ml 5% glucose solution, 1 times a day 30 minutes before coronary artery recanalization; 60 patients (control group) received only standard therapy. Efficacy was evaluated by the content of lipid hydroperoxides, diene conjugates, malonic dialdehyde and activity of the major components of the antioxidant system (ceruloplasmin, vitamin E) in blood of patients. Results. The introduction of cytoflavin patients contributed to a significant decrease in plasma lipid hydroperoxides on 20%, diene conjugates - by 29%, malonic dialdehyde – on 28% after 12 hours of recanalization coronary artery compared with patients in the control group. While analyzing the effect of the succinate containin drugs on the activity of components of antioxidant system it was found that the levels of ceruloplasmin in the blood was higher than in patients of control group in 25%, vitamin E - 21%. Conclusion. The inclusion of Cytoflavin in the treatment of patients with acute myocardial infarction should be considered as pathogenetically justified, clinically justified and promising.