The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kozlov I.A.

GBUZ MO «Moscow Regional Scientific Research Clinical Institute named after M.V. Vladimirsky», Moscow, Russia

Dexmedetomidine for anesthetic and resuscitative providing of cardiac surgery

Authors:

Kozlov I.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2014;7(4): 100‑108

Views: 1421

Downloaded: 60

Download PDF (RU)
Contact the author
Table of contents

DEXMEDETOMIDINE FOR ANESTHETIC AND RESUSCITATIVE PROVIDING OF CARDIAC SURGERY
DEXMEDETOMIDINE FOR ANESTHETIC AND RESUSCITATIVE PROVIDING OF CARDIAC SURGERY

To cite this article:

Kozlov IA. Dexmedetomidine for anesthetic and resuscitative providing of cardiac surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2014;7(4):100‑108. (In Russ.)

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Patient safety in on-pump surgeries. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(4):463-469
Influence of inte­stinal microbiota on cardiovascular athe­rosclerotic diseases and colo­rectal cancer in elde­rly patients. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(1):30-36
Airway mana­gement in obese patients: a review. Russian Journal of Anesthesiology and Reanimatology. 2024;(3):67-73
Postoperative sternomediastinitis: morphology of lesion, treatment stra­tegy. Piro­gov Russian Journal of Surgery. 2024;(7):78-84
Effi­cacy of inte­nsive therapy for massive intraoperative blood loss in children: expe­rience of the Moro­zov Hospital. Piro­gov Russian Journal of Surgery. 2024;(7):103-110
Caro­tid Doppler ultrasound data as predictors of fluid responsiveness. Russian Journal of Anesthesiology and Reanimatology. 2024;(4):14-23
Inte­raction within multidisciplinary cardiac team. How to increase effi­ciency. Medi­cal Technologies. Asse­ssment and Choice. 2024;(3):53-61
Prognostic scale for early dete­ction of various postoperative complications after thoracic aortic surgery: post-hoc analysis of biomarkers. Piro­gov Russian Journal of Surgery. 2024;(10):38-48
History of anti-embolic protection in cardiac surgery. Piro­gov Russian Journal of Surgery. 2024;(12-2):139-149
Difficult intu­bation risk asse­ssment in bariatric surgery. Russian Journal of Anesthesiology and Reanimatology. 2025;(1):62-68

Keywords:

dexmedetomidine
anesthesiology
intensive care
cardiac surgery
organs protection

Authors:

Kozlov I.A.

GBUZ MO «Moscow Regional Scientific Research Clinical Institute named after M.V. Vladimirsky», Moscow, Russia

List of references:

  1. Dygalo N.N. Retseptory gormonov, nejrotransmitterov i tkanevykh faktorov [Receptors for hormones, neurotransmitters and tissue factors]. Novosibirsk: Izd-vo NGU 2001. (in Russian)
  2. Eremenko А.А., CHernova E.V. Primenenie deksmedetomidina dlya vnutrivennoj sedatsii i lecheniya deliriya v rannem posleoperatsionnom periode u kardiokhirurgicheskikh patsientov [Application of dexmedetomidine for intravenous sedation and treatment of delirium in the early postoperative period in patients undergoing cardiac surgery]. Аnesteziol i reanimatol 2013; 5: 4-8. (in Russian)
  3. Kozlov I.А. Аgonist al'fa2-adrenoretseptorov deksmedetomidin v praktike sovremennoj sedatsii [Alpha2-adrenoceptor agonist dexmedetomidine in the modern practice of sedation]. Obshhaya reanimatologiya 2013; 2: 55-65. (in Russian)
  4. Kozlov I.А., Burzhunova M.G., CHumakov M.V., Timerbaev V.KH. Perioperatsionnaya dinamika i klinicheskaya znachimost' soderzhaniya natrijureticheskogo peptida B-tipa v krovi kardiokhirurgicheskikh bol'nykh [Perioperative dynamics and clinical significance of blood natriuretic peptide B-type in cardiac patients]. Obshhaya reanimatologiya 2012; 8: 4: 133-138. (in Russian)
  5. Kozlov I.А., KHarlamova I.E. Natrijureticheskie peptidy: biokhimiya, fiziologiya, klinicheskoe ispol'zovanie [Natriuretic peptides: biochemistry, physiology, clinical use].Obshhaya reanimatologiya 2009; 5: 1: 89-97. (in Russian)
  6. Kulikov А.S., Lubnin А.YU. Deksmedetomidin: novye vozmozhnosti v anesteziologii [Dexmedetomidine: new opportunities in anesthesiology]. Аnesteziol i reanimatol 2013; 1: 37-41. (in Russian)
  7. Tolkushkina D.N. Znachenie golubogo pyatna (Locus Coeruleus) v bul'barnykh mekhanizmakh regulyatsii dykhaniya [Meaning coeruleus (Locus Coeruleus) in bulbar respiratory mechanisms of regulation]: Аvtoref. dis. kand. med. nauk. Samara 2007. (in Russian)
  8. SHumakov V.I., Kozlov I.А., KHotev А.ZH., Markin S.M., Аlferov А.V. Opyt shirokogo vnedreniya rannej aktivizatsii bol'nykh, operiruemykh s ispol'zovaniem iskusstvennogo krovoobrashheniya [Experience the widespread introduction of early mobilization of patients undergoing surgery with cardiopulmonary bypass]. Grudnaya i serdechno-sosud khir 2003; 2: 28-32. (in Russian)
  9. Afonso J., Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol 2012; 62: 1: 118-133. DOI: 10.1016/S0034-7094(12)70110-1.
  10. Ahlquist R.P. A study of the adrenotropic receptors. Am J Physiol 1948; 153: 586-600.
  11. Akada S., Takeda S., Yoshida Y., Nakazato K., Mori M., Hongo T., Tanaka K., Sakamoto A. The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study. Anesth Analg 2008; 107: 1: 167-170.
  12. Andrzejewski M., Muckenhoff K., Scheid P., Ballantyne D. Synchronized rhythms in chemosensitive neurons of the locus coeruleus in the absence of chemical synaptic transmission. Respir Physiol 2001; 129: 1-2: 123-140.
  13. Anger K.E., Szumita P.M., Baroletti S.A., Labreche M.J., Fanikos J. Evaluation of dexmedetomidine versus propofol-based sedation therapy in mechanically ventilated cardiac surgery patients at a tertiary academic medical center. Crit Pathw Cardiol 2010; 9: 4: 221-226. DOI: 10.1097/HPC.0b013e3181f4ec4a.
  14. Aziz N.A., Chue M.C., Yong C.Y., Hassan Y., Awaisu A., Hassan J., Kamarulzaman M.H. Efficacy and safety of dexmedetomidine versus morphine in post-operative cardiac surgery patients. Int J Clin Pharm 2011; 33: 2: 150-154. DOI 10.1007/s11096-011-9480-7.
  15. Barletta J.F., Miedema S.L., Wiseman D., Heiser J.C., McAllen K.J. Impact of dexmedetomidine on analgesic requirements in patients after cardiac surgery in a fast-track recovery room setting. Pharmacotherapy 2009; 29: 12: 1427-1432. DOI: 10.1592/phco.29.12.1427.
  16. Barr J., Fraser G.L., Putillo K., Ely E.W., Gélinas C., Dasta J.F., Davidson J.E., Devlin J.W., Kress J.P., Joffe A.M., Coursin D.B., Herr D.L., Tung A., Robinson B.R., Fontaine D.K., Ramsay M.A., Riker R.R., Sessler C.N., Pun B., Skrobik Y., Jaeschke R. Clinical practice guidelines for the management of pain, agitation, and Delirium in adult patients in the intensive care unit. Crit Care Med 2013; 41: 1: 203-306. DOI: 10.1097/CCM.­0b013e3182783b72.
  17. Barton K.P., Munoz R., Morell V.O., Chrysostomou C. Dexmedetomidine as the primary sedative during invasive procedures in infants and toddlers with congenital heart disease. Pediatr Crit Care Med 2008; 9: 6: 612-615. DOI: 10.1097/PCC.0b013e31818d320d.
  18. Billings F.T. 4th, Chen S.W., Kim M., Park S.W., Song J.H., Wang S., Herman J., D'Agati V., Lee H.T. Alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. Am J Physiol Renal Physiol 2008; 295: 3: F741-F748. DOI: 10.1152/ajprenal.90244.2008.
  19. Bloor B.C., Flacke W.E. Reduction in halothane anesthetic requirement by clonidine, an alpha-adrenergic agonist. Anesth Analg 1982; 61: 9: 741-745.
  20. Boussofara M., Mtaallah M.H., Nefaa M.N., Kaddour C. Clonidine and anesthesia. Tunis Med 2004; 82: 3: 249-257.
  21. Brown E.N., Lydic R., Schiff N.D. General anesthesia, sleep, and coma. N Engl J Med 2010; 363: 27: 2638-2650.
  22. Buck M.L. Dexmedetomidine use in pediatric intensive care and procedural sedation. J Pediatr Pharmacol Ther 2010; 15: 1: 17-29.
  23. But A.K., Ozgul U., Erdil F., Gulhas N., Toprak H.I., Durmus M., Ersoy M.O. The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Acta Anaesthesiol Scand 2006; 50: 10: 1207-1212.
  24. Chrysostomou C., Sanchez-de-Toledo J., Wearden P., Jooste E.H., Lichtenstein S.E., Callahan P.M., Suresh T., O'Malley E., Shiderly D., Haney J., Yoshida M., Orr R., Munoz R., Morell V.O. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations. Ann Thorac Surg 2011; 92: 3: 964-972. DOI: 10.1016/j.athoracsur.2011.04.099.
  25. Corbett S.M., Rebuck J.A., Greene C.M., Callas P.W., Neale B.W., Healey M.A., Leavitt B.J. Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Crit Care Med 2005; 33: 5: 940-945.
  26. Coughlan M.G., Lee J.G., Bosnjak Z.J., Schmeling W.T., Kampine J.P., Warltier D.C. Direct coronary and cerebral vascular responses to dexmedetomidine. Significance of endogenous nitric oxide synthesis. Anesthesiology 1992; 77: 5: 998-1006.
  27. Curtis J.A., Hollinger M.K., Jain H.B. Propofol-based versus dexmedetomidine-based sedation in cardiac surgery patients. J Cardiothorac Vasc Anesth 2013; 27: 6: 1289-1294. DOI: 10.1053/j.jvca.2013.03.022.
  28. Dahmani S., Paris A., Jannier V., Hein L., Rouelle D., Scholz J., Gressens P., Mantz J. Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology 2008; 108: 3: 457-466.
  29. Dasta J.F., Jacobi J., Sesti A.M., McLaughlin T.P. Addition of dexmedetomidine to standard sedation regimens after cardiac surgery: an outcomes analysis. Pharmacotherapy 2006; 26: 6: 798-805.
  30. Delwadia S., Naguib A., Tobias J.D. Dexmedetomidine controls supraventricular tachycardia following cardiac surgery in a child. World J. Pediatr. Congenit Heart Surg 2012; 3: 3: 406-409. DOI: 10.1177/2150135111421352.
  31. Ebert T.J., Hall E.J., Barney J.A., Uhrich T.D., Colinco M.D. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000; 93: 2: 382-394.
  32. Filosa J.A., Putnam R.W. Multiple targets of chemosensitive signaling in locus coeruleus neurons: role of K+ and Ca2+ channels. Am J Physiol Cell Physiol 2003; 284: 1: 145-149.
  33. Friesen R.H., Nichols C.S., Twite M.D., Cardwell K.A., Pan Z., Pietra B., Miyamoto S.D., Auerbach S.R., Darst J.R., Ivy D.D. The hemodynamic response to dexmedetomidine loading dose in children with and without pulmonary hypertension. Anesth Analg 2013; 117: 4: 953-959. DOI: 10.1213/ANE.0b013e3182a15aa6.
  34. Gertler R., Brown H.C., Mitchell D.H., Silvius E.N. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent) 2001; 14: 1: 13-21.
  35. Gu J., Sun P., Zhao H., Watts H.R., Sanders R.D., Terrando N., Xia P., Maze M., Ma D. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit Care 2011; 15: 3: R153. DOI: 10.1186/cc10283.
  36. Guo H., Takahashi S., Cho S., Hara T., Tomiyasu S., Sumikawa K. The effects of dexmedetomidine on left ventricular function during hypoxia and reoxygenation in isolated rat hearts. Anesth Analg 2005; 100: 3: 629-635.
  37. Hammer G.B., Drover D.R., Cao H., Jackson E., Williams G.D., Ramamoorthy C., Van Hare G.F., Niksch A., Dubin A.M. The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg 2008; 106: 1: 79-83.
  38. Hanouz J.L., Zhu L., Persehaye E., Massetti M., Babatasi G., Khayat A., Ducouret P., Plaud B., Gérard J.L. Ketamine preconditions isolated human right atrial myocardium: roles of adenosine triphosphate-sensitive potassium channels and adrenoceptors. Anesthesiology 2005; 102: 6: 1190-1196.
  39. Herr D.L., Sum-Ping S.T., England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth 2003; 17: 5: 576-584.
  40. Hsu Y.W., Cortinez L.I., Robertson K.M., Keifer J.C., Sum-Ping S.T., Moretti E.W., Young C.C., Wright D.R., Macleod D.B., Somma J. Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 2004; 101: 5: 1066-1076.
  41. Hunter J.C., Fontana D.J., Hedley L.R., Jasper J.R., Lewis R., Link R.E., Secchi R., Sutton J., Eglen R.M. Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997; 122: 7: 1339-1344.
  42. Huupponen E., Maksimow A., Lapinlampi P., Särkelä M., Saastamoinen A., Snapir A., Scheinin H., Scheinin M., Meriläinen P., Himanen S.L., Jääskeläinen S. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 2008; 52: 2: 289-294.
  43. Iirola T., Aantaa R., Laitio R., Kentala E., Lahtinen M., Wighton A., Garratt C., Ahtola-Sätilä T., Olkkola K.T. Pharmacokinetics of prolonged infusion of highdose dexmedetomidine in critically ill patients. Crit Care 2011; 15: 5: R257.
  44. Jakob S.M., Ruokonen E., Grounds R.M., Sarapohja T., Garratt C., Pocock S.J., Bratty J.R., Takala J. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 2012; 307: 11: 1151-1160. DOI: 10.1001/jama.2012.304.
  45. Jalonen J., Hynynen M., Kuitunen A., Heikkilä H., Perttilä J., Salmenperä M., Valtonen M., Aantaa R., Kallio A. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology 1997; 86: 2: 331-345.
  46. Ji F., Li Z., Nguyen H., Young N., Shi P., Fleming N., Liu H. Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery. Circulation 2013; 127: 15: 1576-1584. DOI: 10.1161/CIRCULATIONAHA.112.000936. Epub 2013 Mar 19.
  47. Jooste E.H., Muhly W.T., Ibinson J.W., Suresh T., Damian D., Phadke A., Callahan P., Miller S., Feingold B., Lichtenstein S.E., Cain J.G., Chrysostomou C., Davis P.J. Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization. Anesth Analg 2010; 111: 6: 1490-1496. DOI:10.1213/ANE.0b013e3181f7e2ab.
  48. Junaid A., Cui L., Penner S.B., Smyth D.D. Regulation of aquaporin-2 expression by the alpha(2)-adrenoceptor agonist clonidine in the rat. J Pharmacol Exp Ther 1999; 291: 2: 920-923.
  49. Kabukçu H.K., Sahin N., Temel Y., Titiz T.A. Hemodynamics in coronary artery bypass surgery. Effects of intraoperative dexmedetomidine administration. Anaesthesist 2011; 60: 5: 427-431. DOI 10.1007/s00101-010-1842-3.
  50. Kalso E.A., Poyhia R., Rosenberg P.H. Spinal antinociception by dexmedetomidine, a highly selective alpha2-adrenergic agonist. Pharmacol Toxicol 1991; 68: 2: 140-143.
  51. Kamibayashi T., Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology 2000; 93: 5: 1345-1349.
  52. Kaukinen S. Effects of antihypertensive medication on the cardiovascular response to ketamine in rats. Acta Anaesthesiol Scand 1978; 22: 4: 437-446.
  53. Kaukinen S., Pyykkö K. The potentiation of halothane anaesthesia by clonidine. Acta Anaesthesiol Scand 1979; 23: 1: 107-111.
  54. Kaukinen S., Ylitalo P. The effects of antihypertensive medication on the control of the cardiovascular system during halothane anaesthesia in rats. Acta Anaesthesiol Scand 1978; 22: 1: 64-75.
  55. Khalil M.A., Abdel Azeem M.S. The impact of dexmedetomidine infusion in sparing morphine consumption in off-pump coronary artery bypass grafting. Semin Cardiothorac Vasc Anesth 2013; 17: 1: 66-71. DOI: 10.1177/1089253212463969.
  56. Klamt J.G., de Andrade Vicente W.V., Garcia L.V., Ferreira C.A. Effect of dexmedetomidine-fentanyl infusion on blood pressure and heart rate during cardiac surgery in children. Anesth Res Pract 2010; 2010: pii: 869049. DOI: 10.1155/2010/869049.
  57. Klamt J.G., de Andrade Vicente W.V., Garcia L.V., Ferreira C.A. Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanylin children undergoing cardiac surgery with cardiopulmonary bypass. Rev Bras Anestesiol 2010; 60: 4: 350-362. DOI: 10.1016/S0034-7094(10)70044-1.
  58. Koroglu A., Demirbilek S., Teksan H., Sagir O., But A.K., Ersoy M.O. Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results. Br J Anaesth 2005; 94: 6: 821-824.
  59. Koroglu A., Teksan H., Sagir O., Yucel A., Toprak H.I., Ersoy O.M. A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesth Analg 2006; 103: 1: 63-67.
  60. Koruk S., Mizrak A., Kaya Ugur B., Ilhan O., Baspinar O., Oner U. Propofol/dexmedetomidine and propofol/ketamine combinations for anesthesia in pediatric patients undergoing transcatheter atrial septal defect closure: a prospective randomized study. Clin Ther 2010; 32: 4: 701-709. DOI: 10.1016/j.clinthera.2010.04.010.
  61. Kudo L.H., Hébert C.A., Rouch A.J. Inhibition of water permeability in the rat collecting duct: effect of imidazoline and alpha-2 compounds. Proc Soc Exp Biol Med 1999; 221: 2: 136-146.
  62. Kulka P.J., Tryba M., Zenz M. Preoperative alpha2-adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: results of a randomized, controlled trial. Crit Care Med 1996; 24: 6: 947-952.
  63. Kunisawa T., Nagata O., Nagashima M., Mitamura S., Ueno M., Suzuki A., Takahata O., Iwasaki H. Dexmedetomidine suppresses the decrease in blood pressure during anesthetic induction and blunts the cardiovascular response to tracheal intubation. J Clin Anesth 2009; 21: 3: 194-199. DOI: 10.1016/j.jclinane.2008.08.015.
  64. Kunisawa T., Ueno M., Kurosawa A., Nagashima M., Hayashi D., Sasakawa T., Suzuki A., Takahata O., Iwasaki H. Dexmedetomidine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypass. J Anesth 2011; 25: 6: 818-822. DOI: 10.1007/s00540-011-1215-3.
  65. Lazar H.L. How important is glycemic control during coronary artery bypass? Adv Surg 2012; 46: 219-235.
  66. Leino K., Hynynen M., Jalonen J., Salmenperä M., Scheinin H., Aantaa R. Dexmedetomidine in Cardiac Surgery Study Group. Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study. BMC Anesthesiol 2011; 11: 9. DOI: 10.1186/1471-2253-11-9.
  67. LeRiger M., Naguib A., Gallantowicz M., Tobias J.D. Dexmedetomidine controls junctional ectopic tachycardia during Tetralogy of Fallot repair in an infant. Ann Card Anaesth 2012; 15: 3: 224-228. DOI: 10.4103/0971-9784.97978.
  68. Lin Y., Chen J., Wang Z. Meta-analysis of factors which influence delirium following cardiac surgery. J Card Surg 2012; 27: 4: 481-492. DOI: 10.1111/j.1540-8191.2012.01472.x.
  69. Lin Y.Y., He B., Chen J., Wang Z.N. Can dexmedetomidine be a safe and efficacious sedative agent in post-cardiac surgery patients? A metaanalysis. Crit Care 2012; 16: R169-R179. http://ccforum.com/content/16/5/R169.
  70. Loponen P., Luther M., Wistbacka J.O., Nissinen J., Sintonen H., Huhtala H., Tarkka M.R. Postoperative delirium and health related quality of life after coronary artery bypass grafting. Scand Cardiovasc J 2008; 42: 5: 337-344. DOI: 10.1080/14017430801939217.
  71. Ma D., Hossain M., Rajakumaraswamy N., Arshad M., Sanders R.D., Franks N.P., Maze M. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Eur J Pharmacol 2004; 502: 1-2: 87-97.
  72. Mahmoud M., Gunter J., Donnelly L.F., Wang Y., Nick T.G., Sadhasivam S. A. comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children. Anesth Analg 2009; 109: 3: 745-753. DOI: 10.1213/ane.0b013e3181adc506.
  73. Maldonado J.R., Wysong A., van der Starre P.J., Block T., Miller C., Reitz B.A. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 2009; 50: 3: 206-217. DOI: 10.1176/appi.psy.50.3.206.
  74. Maze M., Segal I.S., Bloor B.C. Clonidine and other alpha2-adrenergic agonists: strategies for the rational use of these novel anesthetic agents. J Clin Anesth 1988; 1: 2: 146-157.
  75. Maze M., Virtanen R., Daunt D., Banks S.J., Stover E.P., Feldman D. Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies. Anesth Analg 1991; 73: 2: 204-208.
  76. Mester R., Easley R.B., Brady K.M., Chilson K., Tobias J.D. Monitored anesthesia care with a combination of ketamine and dexmedetomidine during cardiac catheterization. Аm J Ther 2008; 15: 1: 24-30. DOI: 10.1097/MJT.0b013e3180a72255.
  77. Mizobe T., Maze M. Alpha2-adrenoceptor agonists and anesthesia. Int Anesthesiol Clin 1995; 33: 1: 81-102.
  78. Molojavyi A., Preckel B., Comfère T., Müllenheim J., Thämer V., Schlack W. Effects of ketamine and its isomers on ischemic preconditioning in the isolated rat heart. Anesthesiology 2001; 94: 4: 623-629.
  79. Mowafi H.A., Aldossary N., Ismail S.A., Alqahtani J. Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation. Br J Anaesth 2008; 100: 4: 485-489.
  80. Nagiub A., McKee C., Phillips A., Tobias J.D. Dexmedetomidine as the primary anesthetic agent during cardiac surgery in an infant with a family history of malignant hyperthermia. Saudi J Anaest 2011; 5: 4: 426-429. DOI: 10.4103/1658-354X.87276.
  81. Nathan H.J., Feigl E.O. Adrenergic vasoconstriction lessens transmural steal during coronary hypoperfusion. Am J Physiol 1986; 250: 4: Pt 2: H645-H653.
  82. Neema P.K. Dexmedetomidine in pediatric cardiac anesthesia. Ann Card Anaesth 2012; 15: 3: 177-179. DOI: 10.4103/0971-9784.97972.
  83. Nelson L.E., Lu J., Guo T., Saper C.B., Franks N.P., Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology 2003; 98: 2: 428-436.
  84. Neuhäuser C., Preiss V., Feurer M.K., Müller M., Scholz S., Kwapisz M., Mogk M., Welters I.D. Comparison of S-(+)-ketamine- with sufentanil-based anaesthesia for elective coronary artery bypass graft surgery: effect on troponin T levels. Br J Anaesth 2008; 100: 6: 765-771. DOI: 10.1093/bja/aen095.
  85. Okada H., Kurita T., Mochizuki T., Morita K., Sato S. The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts. Resuscitation 2007; 74: 3: 538-545.
  86. Pagel P.S., Hettrick D.A., Kersten J.R., Warltier D.C. Dexmedetomidine produces similar alterations in the determinants of left ventricular afterload in conscious dogs before and after the development of pacing-induced cardiomyopathy. Anesthesiology 1998; 89: 3: 741-748.
  87. Pandharipande P.P., Pun B.T., Herr D.L., Maze M., Girard T.D., Miller R.R., Shintani A.K., Thompson J.L., Jackson J.C., Deppen S.A., Stiles R.A., Dittus R.S., Bernard G.R., Ely E.W. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 2007; 298: 22: 2644-2653.
  88. Perez H., Ruiz S. Medullary responses to chemoreceptor activation are inhibited by locus coeruleus and nucleus raphe magnus. Neuroreport 1995; 6: 10: 1373-1376.
  89. Pettinger W.A., Umemura S., Smyth D.D., Jeffries W.B. Renal alpha 2 adrenoreceptors and the adenylate cyclase-c-AMP system: biochemical and physiological interactions. Am J Physiol 1987; 252: 2: Pt 2: F199-F208.
  90. Reardon D.P., Anger K.E., Adams C.D., Szumita P.M. Role of dexmedetomidine in adults in the intensive care unit: an update. Am J Health Syst Pharm 2013; 70: 9: 767-777. DOI 10.2146/ajhp120211.
  91. Reichert M.G., Jones W.A., Royster R.L., Slaughter T.F., Kon N.D., Kincaid E.H. Effect of a dexmedetomidine substitution during a nationwide propofol shortage in patients undergoing coronary artery bypass graft surgery. Pharmacotherapy 2011; 31: 7: 673-677. DOI: 10.1592/phco.31.7.673.
  92. Ríha H., Kotulák T., Březina A., Hess L., Kramář P., Szárszoi O., Netuka I., Pirk J. Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study. Physiol Res 2012; 61: 1: 63-72.
  93. Riker R.R., Shehabi Y., Bokesch P.M., Ceraso D., Wisemandle W., Koura F., Whitten P., Margolis B.D., Byrne D.W., Ely E.W., Rocha M.G. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial (SEDCOM). JAMA 2009; 301: 5: 489-499.
  94. Roekaerts P.M., Prinzen F.W., De Lange S. Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs. Br J Anaesth 1996; 77: 3: 427-429.
  95. Rouch A.J., Kudo L.H., Hébert C. Dexmedetomidine inhibits osmotic water permeability in the rat cortical collecting duct. J Pharmacol Exp Ther 1997; 281: 1: 62-69.
  96. Ruokonen E., Parviainen I., Jakob S.M., Nunes S., Kaukonen M., Shepherd S.T., Sarapohja T., Bratty J.R., Takala J. Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intens Care Med 2009; 35: 2: 282-290.
  97. Sabbe M.B., Penning J.P., Ozaki G.T., Yaksh T.L. Spinal and systemic action of the alpha2 receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide response. Anesthesiology 1994; 80: 5: 1057-1072.
  98. Sanders R.D., Xu J., Shu Y., Januszewski A., Halder S., Fidalgo A., Sun P., Hossain M., Ma D., Maze M. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 2009; 110: 5: 1077-1085. DOI: 10.1097/ALN.0b013e31819daedd.
  99. Sandimenge A. Sedation of ventilated patients and analgesia. Clin Pulm Med 2010; 17: 6: 290-299.
  100. Sato K., Kimura T., Nishikawa T., Tobe Y., Masaki Y. Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats. Acta Anaesthesiol Scand 2010; 54: 3: 377-382. DOI: 10.1111/j.1399-6576.2009.02139.x.
  101. Segal I.S., Vickery R.G., Walton J.K., Doze V.A., Maze M. Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology 1988; 69: 6: 818-823.
  102. Shehabi Y., Grant P., Wolfenden H., Hammond N., Bass F., Campbell M., Chen J. Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). Anesthesiology 2009; 111: 5: 1075-1084. DOI: 10.1097/ALN.0b013e3181b6a783.
  103. Siepe M., Pfeiffer T., Gieringer A., Zemann S., Benk C., Schlensak C., Beyersdorf F. Increased systemic perfusion pressure during cardiopulmonary bypass is associated with less early postoperative cognitive dysfunction and delirium. Eur J Cardiothorac Surg 2011; 40: 1: 200-207. DOI: 10.1016/j.ejcts.2010.11.024.
  104. Sulaiman S., Karthekeyan R.B., Vakamudi M., Sundar A.S., Ravullapalli H., Gandham R. The effects of dexmedetomidine on attenuation of stress response to endotracheal intubation in patients undergoing elective off-pump coronary artery bypass grafting. Ann Card Anaesth 2012; 15: 1: 39-43. DOI: 10.4103/0971-9784.91480.
  105. Székely A., Levin J., Miao Y., Tudor I.C., Vuylsteke A., Ofner P., Mangano D.T. Impact of hyperglycemia on perioperative mortality after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg 2011; 142: 2: 430-437.e1. DOI: 10.1016/j.jtcvs.2011.03.009.
  106. Talke P., Chen R., Thomas B., Aggarwall A., Gottlieb A., Thorborg P., Heard S., Cheung A., Son S.L., Kallio A. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 2000; 90: 4: 834-839.
  107. Talke P., Li J., Jain U., Leung J., Drasner K., Hollenberg M., Mangano D.T. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology 1995; 82: 3: 620-633.
  108. Talke P., Tayefeh F., Sessler D.I., Jeffrey R., Noursalehi M., Richardson C. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology 1997; 87: 4: 835-841.
  109. Tamsen A., Gordh T. Epidural clonidine produces analgesia. Lancet 1984; 2: 8396: 231-232.
  110. Tobias J.D., Chrysostomou C. Dexmedetomidine: antiarrhythmic effects in the pediatric cardiac patient. Pediatr Cardiol 2013; 34: 4: 779-785. DOI: 10.1007/s00246-013-0659-7.
  111. Tobias J.D., Gupta P., Naguib A., Yates A.R. Dexmedetomidine: applications for the pediatric patient with congenital heart disease. Pediatr Cardiol 2011; 32: 8: 1075-1087. doi: 10.1007/s00246-011-0092-8.
  112. Torbic H., Papadopoulos S., Manjourides J., Devlin J.W. Impact of a protocol advocating dexmedetomidine over propofol sedation after robotic-assisted direct coronary artery bypass surgery on duration of mechanical ventilation and patient safety. Ann Pharmacother 2013; 47: 4: 441-446. DOI: 10.1345/aph.1S156.
  113. Tosun Z., Baktir M., Husnu С.K., Baskol G., Guler G., Boyaci A. Does Dexmedetomidine provide cardioprotection in coronary artery bypass grafting with cardiopulmonary bypass? A pilot study. J Cardiothorac Vasc Anesthes 2013; 27: 4: 710-715.
  114. Tse L., Schwarza S.K.W., Boweringa J.B., Moorea R.L., Burnsb K.D., Richfordb C.M., Osborna J.A., Barr A.M. Pharmacological risk factors for delirium after cardiac surgery: A review. Curr Neuropharmacol 2012; 10: 3: 181-196.
  115. Venn R.M., Hell J., Grounds R.M. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 2000; 4: 5: 302-308.
  116. Venn R.M., Karol M.D., Grounds R.M. Pharmacokinetics of dexmedetomidine infusion for sedation of postoperative patients requring intensive care. Br J Anaesth 2002; 88: 5: 669-675.
  117. Virtanen R., Savola J.M., Saano V., Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1988; 150: 1-2: 9-14.
  118. Wijeysundera D.N., Bender J.S., Beattie W.S. Alpha-2 adrenergic agonists for the prevention of cardiac complications among patients undergoing surgery. Cochrane Database Syst Rev 2009; 7: 4: CD004126.
  119. Wijeysundera D.N., Naik J.S., Beattie W.S. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis. Am J Med 2003; 114: 9: 742-752.
  120. Wunsch H., Kahn J.M., Kramer A.A., Rubenfeld G.D. Use of intravenous infusion sedation among mechanically ventilated patients in the United States. Crit Care Med 2009; 37: 12: 3031-3039.
  121. Wunsch H., Kahn J.M., Kramer A.A., Wagener G., Li G., Sladen R.N., Rubenfeld G.D. Dexmedetomidine in the care of critically ill patients from 2001 to 2007: an observational cohort study. Anesthesiology 2010; 113: 2: 386-394.
  122. Xue F.-S., Cheng Y., Li R.-P. Safety of dexmedetomidine sedation in postoperative cardiac surgery patients. Letter. Crit Care 2013; 17: 3: 435.
  123. Yang C.L., Chen C.H., Tsai P.S., Wang T.Y., Huang C.J. Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats. Surg Res 2011; 167: 2: e273-e281. DOI: 10.1016/j.jss.2010.02.020.
  124. Yapici N., Coruh T., Kehlibar T., Yapici F., Tarhan A., Can Y., Ozler A., Aykac Z. Dexmedetomidine in cardiac surgery patients who fail extubation and present with a delirium state. Heart Surg Forum 2011; 14: 1: E93-E98. DOI: 10.1532/HSF98.201011102.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.