The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Khubulava G.G.

Pervaia kafedra khirurgii usovershenstvovaniia vracheĭ im. akad. P.A. Kupriianova Voenno-meditsinskoĭ akademii, Sankt-Peterburg

Avaliani V.M.

Voenno-meditsinskaia akademiia im. S.M. Kirova;
GBOU VPO Sankt-Peterburgskiĭ gosudarstvennyĭ pediatricheskiĭ meditsinskiĭ universitet Minzdrava Rossii

Myocardial protection during coronary artery bypass grafting: current state of the problem

Authors:

Khubulava G.G., Avaliani V.M.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2013;6(5): 42‑47

Read: 2658 times

Download PDF (RU)
Contact the author
Table of contents

MYOCARDIAL PROTECTION DURING CORONARY ARTERY BYPASS GRAFTING: CURRENT STATE OF THE PROBLEM
MYOCARDIAL PROTECTION DURING CORONARY ARTERY BYPASS GRAFTING: CURRENT STATE OF THE PROBLEM

To cite this article:

Khubulava GG, Avaliani VM. Myocardial protection during coronary artery bypass grafting: current state of the problem. Russian Journal of Cardiology and Cardiovascular Surgery. 2013;6(5):42‑47. (In Russ.)

ЭндоКард
Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Left ante­rior descending artery and diagonal branch bypass in multiple-vessel coro­nary artery disease. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):646-650
Mode­rate ischemic mitral insu­fficiency with severe left ventricular dysfunction: surgical treatment depe­nding on predictors of adve­rse long-term outcomes. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):651-659
Stentectomy following percutaneous coro­nary inte­rvention complicated by perforation of distal anastomosis after previous coro­nary artery bypass grafting. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(1):109-114
Strain echo­cardiography for perioperative asse­ssment of the left ventricle and left atrium in patients unde­rgoing coro­nary artery bypass surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(3):269-279
Imme­diate resu­lts of coro­nary bypass grafting without touching the aorta in patients with multiple-vessel disease: a single-center retrospective study. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(3):280-285
Asse­ssment of the quality of medi­cal care for patients who unde­rwent myocardial reva­scularization in the Russian Fede­ration: the patient, the physician, and the healthcare orga­nizer views. Russian Journal of Preventive Medi­cine. 2024;(12):44-50
Prediction of no-reflow phenomenon in endo­vascular treatment of patients with acute ST segment elevation myocardial infa­rction. Russian Cardiology Bulletin. 2024;(4):52-58
Hemo­dynamic para­meters of venous return and their role in asse­ssment of fluid responsiveness in cardiac surgery. Russian Journal of Anesthesiology and Reanimatology. 2025;(2):6-12
In-hospital resu­lts of coro­nary artery bypass grafting in patients with coro­nary artery disease and unve­rified distal coro­nary bed. Russian Cardiology Bulletin. 2025;(1):81-89
Cognitive impairment after major surgical operations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):74-80
Abstract:

Keywords:

myocardial revascularization
coronary artery bypass grafting
myocardial protection
reperfusion myocardial injury
ischemic preconditioning.

Authors:

Khubulava G.G.

Pervaia kafedra khirurgii usovershenstvovaniia vracheĭ im. akad. P.A. Kupriianova Voenno-meditsinskoĭ akademii, Sankt-Peterburg

Avaliani V.M.

Voenno-meditsinskaia akademiia im. S.M. Kirova;
GBOU VPO Sankt-Peterburgskiĭ gosudarstvennyĭ pediatricheskiĭ meditsinskiĭ universitet Minzdrava Rossii

Close metadata

References:

  1. Akchurin R.S., Margolina A.A., Podlesskikh Yu.S. i dr. Razvitie metodov intraoperatsionnoi zashchity miokarda: put' k sovershenstvu ili doroga v nikuda. Grudnaya i serdechno-sosud khir 2001; 3: 27-30.
  2. Alshibaya M.M., Beknazaryan D.Yu., Abadzhanyan M.F. i dr. Razlichnye metody intraoperatsionnoi zashchity miokarda pri rekonstruktivnykh operatsiyakh anevrizm levogo zheludochka. Byul NTsSSKh im. N.A. Bakuleva RAMN "Serdechno-sosudistye zabolevaniya" 2006; 3: 145.
  3. Belov Yu.V. Rukovodstvo po sosudistoi khirurgii s atlasom operativnoi tekhniki. M: DeNovo 2000.
  4. Bokeriya L.A., Avaliani V.M., Merzlyakov V.Yu. Aortokoronarnoe shuntirovanie na rabotayushchem serdtse. M: NTsSSKh im. A.N. Bakuleva RAMN 2008.
  5. Lishmanov Yu.B., Maslov L.N. Ishemicheskoe postkonditsionirovanie serdtsa. Retseptornye mekhanizmy i vozmozhnosti klinicheskogo primeneniya. Kardiologiya 2010; 6: 68-74.
  6. Petrishchev N.N., Shlyakhto E.V., Tsyrlin V.A. i dr. Rol' svobodnykh radikalov kisloroda v mekhanizmakh lokal'nogo i distantnogo ishemicheskogo prekonditsionirovaniya miokarda. Vestn RAMN 2006; 8: 10-15.
  7. Todosiichuk V.V., Kuznetsov V.A. Vliyanie dipiridamola na fenomen ishemicheskogo prekonditsionirovaniya u bol'nykh ishemicheskoi bolezn'yu serdtsa pri provedenii parnykh veloergometrii. Kardiologiya 2005; 9: 23-25.
  8. Khubulava G.G., Zhuravlev V.P., Biryukov A.V. i dr. Sravnitel'naya otsenka metodov zashchity miokarda pri operatsiyakh koronarnogo shuntirovaniya v usloviyakh iskusstvennogo krovo­obrashcheniya. Anesteziol i kardiorean 2009; 1: 51-55.
  9. Shlyakhto E.V., Galagudze M.M., Nifontov E.M., Shcherbak N.S. Ostroe ishemicheskoe povrezhdenie i zashchita miokarda. Rukovodstvo po aterosklerozu i ishemicheskoi bolezni serdtsa. Pod red. akad. E.I. Chazova. M: Media Medika 2007; 552-573.
  10. Bergsland J., Lingaas P.S., Skulstad H. et al. Intracoronary shunt prevents ischemia in off-pump coronary artery bypass surgery. Ann Thorac Surg 2009; 87: 54-60.
  11. Boyce S.W., Bartels C., Bolli R. et al. GUARD During Ischemia Against Necrosis (GUARDIAN) Study Investigators. Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study. J Thorac Cardiovasc Surg 2003; 126: 420-427.
  12. Brener S.J., Lytle B.W., Schneider J.P. et al. Association between CK-MB elevation after percutaneous or surgical revascularization and three-year mortality. J Am Coll Cardiol 2002; 40: 11: 1961-1967.
  13. Chowdhury U.K., Malik V., Yadav R. et al. Myocardial injury in coronary artery bypass grafting: on-pump versus off-pump comparison by measuring highsensitivity C-reactive protein, cardiac troponin I, heart-type fatty acid-binding protein, creatine kinase-MB, and myoglobin release. J Thorac Cardiovasc Surg 2008; 135: 1110-1119.
  14. Costa M.A., Carere R.G., Lichtenstein S.V. et al. Incidence, predictors, and significance of abnormal cardiac enzyme rise in patients treated with bypass surgery in the arterial revascularization therapies study (ARTS). Circulation 2001; 104: 2689-2693.
  15. Demaria R.G., Fortier S., Malo O. et al. Influence of intracoronary shunt size on coronary endothelial function during off pump coronary artery bypass. Heart Surg Forum 2003; 6: 160-168.
  16. Domanski M.J., Mahaffey K., Hasselblad V. et al. Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery. JAMA 2011; 305: 585-591.
  17. Emmiler M., Kocogullari C.U., Ela Y., Cekirdekci A. Influence of intracoronary shunt on myocardial damage: a prospective randomized study. Eur J Cardiothorac Surg 2008; 34: 1000-1004.
  18. Gurbuz A., Emrecan B., Yilik L. et al. Intracoronary shunt reduces postoperative troponin leaks: a prospective randomized study. Eur J Cardiothorac Surg 2006; 29: 186-189.
  19. Hangler H., Mueller L., Ruttmann E. et al. Shunt or snare: coronary endothelial damage due to hemostatic devices for beating heart coronary surgery. Ann Thorac Surg 2008; 86: 1873-1877.
  20. Hausenloy D.J., Mwamure P.K., Venugopal V. et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet 2007; 370: 575-579.
  21. Hausenloy D.J., Yellon D.M. Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res 2008; 79: 377-386.
  22. Huang C., Gu H., Zhang W. et al. SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. Am J Physiol Heart Circulat Physiol 2011; 301: 1496-505.
  23. Karuppasamy P., Chaubey S., Dew T. et al. Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? Basic Res Cardiol 2011; 106: 511-519.
  24. Klatte K., Chaitman B.R., Theroux P. et al., GUARDIAN Investigators (The GUARD during Ischemia Against Necrosis). Increased mortality after coronary artery bypass graft surgery is associated with increased levels of postoperative creatine kinase-myocardial band isoenzyme release: results from the GUARDIAN trial. J Am Coll Cardiol 2001; 38: 1070-1077.
  25. Kobayashi J., Tashiro T., Ochi M. et al., Japanese Off-Pump Coronary Revascularization Investigation (JOCRI) Study Group. Early outcome of a randomized comparison of off-pump and on-pump multiple arterial coronary revascularization. Circulation 2005; 112: 338-343.
  26. Kottenberg E., Thielmann M., Bergmann L. et al. Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta Anaesthesiol Scand 2012; 56: 30-38.
  27. Lucchinetti E., Bestmann L., Feng J. et al. Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass graft surgery: lack of synergy or evidence of antagonism in cardioprotection? Anesthesiology 2012; 116: 296-310.
  28. Manukyan M.C., Alvernaz C.H., Poynter J.A. et al. Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. Surgery 2011; 150: 231-239.
  29. Alexander J.H., Emery R.W. Jr, Carrier M. et al., MEND-CABG II Investigators. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial. JAMA 2008; 299: 1777-1787.
  30. Mentzer R.M. Jr, Bartels C., Bolli R. et al., EXPEDITION Study Investigators. Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg 2008; 85: 1261-1270.
  31. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-1136.
  32. Puskas J.D., Williams W.H., Duke P.G. et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003; 125: 797-808.
  33. Rahman I.A., Mascaro J.G., Steeds R.P. et al. Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment? Circulation 2010; 122: 53-59.
  34. Smith P.K., Levy J.H., Shernan S.K. Pexelizumab, a terminal complement inhibitor in coronary artery bypass graft surgery: results from the Pexelizumab for the Reduction of Infarction and Mortality in CABG II trial. Program and abstracts from the American College of Cardiology 55 th Annual Scientific Session. Atlanta: 2006; 411-412.
  35. Tapuria N., Kumar Y., Habib M.M. et al. Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury - a review. J Surg Res 2008; 150: 304-330.
  36. Tardif J.C., Carrier M., Kandzari D.E. et al., MENDCABG Investigators. Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study. J Thorac Cardiovasc Surg 2007; 133: 1604-1611.
  37. Testa L., Van Gaal W.J., Bhindi R. et al. Pexelizumab in ischemic heart disease: a systematic review and metaanalysis on 15,196 patients. J Thorac Cardiovasc Surg 2008; 136: 884-893.
  38. Theroux P., Chaitman B.R., Danchin N. et al. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators. Circulation 2000; 102: 3032-3038.
  39. Thielmann M., Kottenberg E., Boengler K. et al. Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest. Basic Res Cardiol 2010; 105: 657-664.
  40. Van de Werf F., Newman M.F., Chen J.C., PRIMO-CABG Investigators, et al. Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial. JAMA 2004; 291: 2319-2327.
  41. Vural A.H., Yalcinkaya S., Turk T. et al. Intracoronary shunt versus bulldog clamp in off-pump bypass surgery. Endothelial trauma: shunt versus clamp. J Surg Res 2008; 150: 261-265.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.