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Afanasieva O.I.

Chazov National Medical Research Center of Cardiology

Arefieva T.I.

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

Tyurina A.V.

Chazov National Medical Research Center of Cardiology

Filatova A.Yu.

Chazov National Medical Research Center of Cardiology

Razova O.A.

Chazov National Medical Research Center of Cardiology

Klesareva E.A.

Chazov National Medical Research Center of Cardiology

Radyukhina N.V.

Chazov National Medical Research Center of Cardiology

Ruleva N.Yu.

Chazov National Medical Research Center of Cardiology

Ezhov M.V.

Chazov National Medical Research Center of Cardiology

Pokrovsky S.N.

Chazov National Medical Research Center of Cardiology

Lipoprotein(a) and triglyceride-rich lipoproteins — association with recurrent nonfatal myocardial infarction in patients with early manifestation of coronary artery disease

Authors:

Afanasieva O.I., Arefieva T.I., Tyurina A.V., Filatova A.Yu., Razova O.A., Klesareva E.A., Radyukhina N.V., Ruleva N.Yu., Ezhov M.V., Pokrovsky S.N.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(1): 29‑37

DOI: 10.17116/Cardiobulletin20241901129

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To cite this article:

Afanasieva OI, Arefieva TI, Tyurina AV, et al. . Lipoprotein(a) and triglyceride-rich lipoproteins — association with recurrent nonfatal myocardial infarction in patients with early manifestation of coronary artery disease. Russian Cardiology Bulletin. 2024;19(1):29‑37. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20241901129

Подписка 2025 (Russian Cardiology Bulletin)
 
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Elevated serum lipoprotein(a) is associated with early manifestation of coronary artery disease and higher risk of acute cardiovascular events including myocardial infarction. Neutrophil granulocyte activation leading to cell death is accompanied by release of various inflammatory and thrombotic mediators. These substances cause atherosclerotic plaque destabilization. In this study, we have shown that netosis in primary culture of neutrophils is stimulated by lipoprotein(a) rather triglyceride-rich lipoproteins. We found a correlation between lipoprotein (a) and neutrophil elastase content in homogenates of human coronary artery atherosclerotic plaques. In patients with early manifestation of coronary artery disease and lipoprotein(a) >30 mg/dL, the content of circulating neutrophils correlated with remnant cholesterol as a component of triglyceride-rich lipoproteins. Hyperlipoproteinemia(a) and low-molecular-weight apolipoprotein(a) phenotype independently increased the risk of recurrent myocardial infarction. This risk was maximal in case of additional elevation of remnant cholesterol. These data suggest that triglyceride-rich lipoproteins accompanied by hyperlipoproteinemia(a) and low-molecular-weight apo(a) phenotype contribute to aggravation of inflammatory process in the vascular wall via stimulation of leukocyte recruitment.

Keywords:

lipoprotein(a)
triglyceride-rich lipoproteins
neutrophil granulocytes
atherosclerosis
myocardial infarction

Authors:

Afanasieva O.I.

Chazov National Medical Research Center of Cardiology

Arefieva T.I.

Chazov National Medical Research Center of Cardiology;
Lomonosov Moscow State University

Tyurina A.V.

Chazov National Medical Research Center of Cardiology

Filatova A.Yu.

Chazov National Medical Research Center of Cardiology

Razova O.A.

Chazov National Medical Research Center of Cardiology

Klesareva E.A.

Chazov National Medical Research Center of Cardiology

Radyukhina N.V.

Chazov National Medical Research Center of Cardiology

Ruleva N.Yu.

Chazov National Medical Research Center of Cardiology

Ezhov M.V.

Chazov National Medical Research Center of Cardiology

Pokrovsky S.N.

Chazov National Medical Research Center of Cardiology

Received:

17.11.2023

Accepted:

23.11.2023

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