sST2 protein in working persons, its relationship with functional and biochemical markers of cardiovascular risk

Blinova T.V.; Strakhova L.A.; Umnyagina I.A.; Troshin V.V.; Ivanova Yu.V.

doi:https://doi.org/10.17116/Cardiobulletin20221703151

Blinova T.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Strakhova L.A.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Umnyagina I.A.

Nizhny Novgorod Research Institute for Hygiene and Occupational Pathology

Troshin V.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Ivanova Yu.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

sST2 protein in working persons, its relationship with functional and biochemical markers of cardiovascular risk

Authors:

Blinova T.V., Strakhova L.A., Umnyagina I.A., Troshin V.V., Ivanova Yu.V.

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Journal: Russian Cardiology Bulletin. 2022;17(3): 51‑57

DOI: 10.17116/Cardiobulletin20221703151

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To cite this article:

Blinova TV, Strakhova LA, Umnyagina IA, Troshin VV, Ivanova YuV. sST2 protein in working persons, its relationship with functional and biochemical markers of cardiovascular risk. Russian Cardiology Bulletin. 2022;17(3):51‑57. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221703151

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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OBJECTIVE

To assess serum sST2 protein in young and middle-aged workers and to establish its relationship with cardiovascular risk factors.

MATERIAL AND METHODS

The study included 86 workers of metallurgical plant of the Nizhny Novgorod region. These were men aged 29—51 years (mean age 39.1±9.5 years, period of employment 14.5±7.7 years, health group II). We analyzed serum sST2 protein, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, glucose, indicators of oxidative stress, antioxidant capacity of serum and reduced glutathione. All individuals underwent standard 12-lead electrocardiography. Body mass index and blood pressure were measured.

RESULTS

Incidence of increased/decreased functional and biochemical indicators of cardiovascular risk was higher in serum sST2 within the reference values (20.0—34.0 ng/ml) compared to sST2 <20.0 ng/ml. Functional and biochemical indicators did not differ from appropriate values in serum sST2 >34.0 ng/ml exceeding the upper limit of reference values.

CONCLUSION

The relationship between cardiovascular risk and serum sST2 protein in young and middle-aged workers can be detected at a concentration of this protein >26.4±3.9 ng/ml within the reference values. This made it possible to evaluate serum sST2 protein as a possible indicator of cardiovascular risk in young and middle-aged workers.

Keywords:

sST2 protein

healthy individuals

functional and biochemical markers

cardiovascular diseases

Authors:

Blinova T.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Strakhova L.A.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Umnyagina I.A.

Nizhny Novgorod Research Institute for Hygiene and Occupational Pathology

Troshin V.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Ivanova Yu.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Received:

11.04.2022

Accepted:

17.06.2022

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References:

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