sST2 protein in working persons, its relationship with functional and biochemical markers of cardiovascular risk

Blinova T.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Strakhova L.A.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Umnyagina I.A.

Nizhny Novgorod Research Institute for Hygiene and Occupational Pathology

Troshin V.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Ivanova Yu.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

sST2 protein in working persons, its relationship with functional and biochemical markers of cardiovascular risk

Authors:

Blinova T.V., Strakhova L.A., Umnyagina I.A., Troshin V.V., Ivanova Yu.V.

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Journal: Russian Cardiology Bulletin. 2022;17(3): 51‑57

DOI: 10.17116/Cardiobulletin20221703151

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To cite this article:

Blinova TV, Strakhova LA, Umnyagina IA, Troshin VV, Ivanova YuV. sST2 protein in working persons, its relationship with functional and biochemical markers of cardiovascular risk. Russian Cardiology Bulletin. 2022;17(3):51‑57. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221703151

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OBJECTIVE

To assess serum sST2 protein in young and middle-aged workers and to establish its relationship with cardiovascular risk factors.

MATERIAL AND METHODS

The study included 86 workers of metallurgical plant of the Nizhny Novgorod region. These were men aged 29—51 years (mean age 39.1±9.5 years, period of employment 14.5±7.7 years, health group II). We analyzed serum sST2 protein, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, glucose, indicators of oxidative stress, antioxidant capacity of serum and reduced glutathione. All individuals underwent standard 12-lead electrocardiography. Body mass index and blood pressure were measured.

RESULTS

Incidence of increased/decreased functional and biochemical indicators of cardiovascular risk was higher in serum sST2 within the reference values (20.0—34.0 ng/ml) compared to sST2 <20.0 ng/ml. Functional and biochemical indicators did not differ from appropriate values in serum sST2 >34.0 ng/ml exceeding the upper limit of reference values.

CONCLUSION

The relationship between cardiovascular risk and serum sST2 protein in young and middle-aged workers can be detected at a concentration of this protein >26.4±3.9 ng/ml within the reference values. This made it possible to evaluate serum sST2 protein as a possible indicator of cardiovascular risk in young and middle-aged workers.

Keywords:

sST2 protein

healthy individuals

functional and biochemical markers

cardiovascular diseases

Authors:

Blinova T.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Strakhova L.A.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Umnyagina I.A.

Nizhny Novgorod Research Institute for Hygiene and Occupational Pathology

Troshin V.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Ivanova Yu.V.

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

Received:

11.04.2022

Accepted:

17.06.2022

List of references:

Boytsov SA, Drapkina OM, Shlyakhto EV, Konradi AO, Balanova YuA, Zhernakova YuV, Metelskaya VA, Oshchepkova EV, Rotar OP, Shalnova SA. Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSERF) study. Ten years later. Kardiovaskulyarnaya terapiya i profilaktika. 2021;20(5):3007. (In Russ.). https://doi.org/10.15829/1728-8800-2021-3007
Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga S, Solomon SD, Rouleau JL, Lee RT. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002;106(23):2961-2966. https://doi.org/10.1161/01.cir.0000038705.69871.d9
Kamardinov DK, Songurov RN, Ioshina VI, Buziashvili YuI. Soluble ST2 — as a biomarker, a tool for risk stratification and therapeutic target in patients with chronic heart failure. Kardiologiia. 2020;60(2):111-121. (In Russ.). https://doi.org/10.18087/cardio.2020.2.n816
Тепляков А.Т., Тарасов Н.И., Исаков Л.К., Гракова Е.В., Синькова М.Н., Копьева К.В., Гармаева О.В., Огуркова О.Н., Калюжин В.В., Калюжина Е.В. Прогноз сердечно-сосудистых событий после имплантации кардиовертерадефибриллятора пациентам с хронической сердечной недостаточностью: значение повышения концентрации ýндотелина-1 и растворимой формы белка ST2 в плазме крови. Бюллетень сибирской медицины. 2018;17(3):140-150.
Teplyakov AT, Tarasov NI, Isakov LK, Grakova EV, Sinkova MN, Kopieva K., Garmaeva OB, Ogurkova ON, Kalyuzhin VV, Kalyuzhina EV. Prognosis of cardiovascular events after implantation of a cardioverter-defibrillator in patients with chronic heart failure: the value of increasing concentration of endothelin-1 and soluble forms of ST2 protein in blood plasma. Byulleten’ sibirskoj mediciny. 2018;17(3):140-150. (In Russ.). https://doi.org/10.20538/1682-0363-2018-3-140-150
Ciccone MM, Cortese F, Gesualdo M, Riccardi R, Di Nunzio D, Moncelli M, Iacoviello M, Scicchitano P. A novel cardiac bio-marker: ST2: a review. Molecules. 2013;18:15314-15328. https://doi.org/10.3390/molecules181215314
Skvortsov AA, Narusov OYu, Muksinova MD, Protasov VN, Protasova DE, Kuznetsova TV, Masenko VP, Tereshchenko SN. Clinical significance of serial biomarkers activity determination after acute heart failure decompensation: sST2 NT-proBNP role during long-term follow-up. Kardiologiia. 2018;58(12S):27-41. (In Russ.). https://doi.org/10.18087/cardio.2634
Prikaz Minzdrava RF ot 13 marta 2019 goda N 124n «Ob utverzhdenii poryadka provedeniya profilakticheskogo meditsinskogo osmotra i dispanserizatsii opredelennykh grupp vzroslogo naseleniya». (In Russ.)
Chazova IE, Zhernakova YuV. on behalf of the experts. Clinical guidelines. Diagnosis and treatment of arterial hypertension. Systemic Hypertension. 2019;16(1):6-31. (In Russ.). https://doi.org/10.26442/2075082X.2019.1.190179
Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen M, Tokgozoglu L, Wiklund O. 2019 ESC/EAS Guidelines for themanagement of dyslipidaemias: lipid modification to reduce cardiovascular risk. Rossiyskiy kardiologicheskiy journal. 2020;25(5):3826. (In Russ.). https://doi.org/10.15829/1560-4071-2020-3826
Giustarini D, Fanti P, Sparatore A, Matteucci E, Rossi R. Anethole dithiolethione lowers the homocysteine and raises the glutathone levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent. Biochem Pharmacol. 2014;89:246-254. https://doi.org/10.1016/j.bcp.2014.03.005
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16):e240-327. https://doi.org/10.1161/CIR.0b013e31829e8776
Zhang T, Xu C, Zhao R, Cao Z. Diagnostic Value of sST2 in Cardiovascular Diseases: A Systematic Review and Meta-Analysis. Frontiers in Cardiovascular Medicine. 2021;8:697837. https://doi.org/10.3389/fcvm.2021.697837
Yndestad A, Marshall AK, Hodgkinson JD, Tham EL, Sugden PH, Clerk A. Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1. International Journal of Biochemistry & Cell Biology. 2010;42:263e272. https://doi.org/10.1016/j.biocel.2009.10.021
Yang Y, Liu H, Zhang H, Ye Q, Wang J, Yang B, Hu X. ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury. Journal of Neuroscience. 2017;37(18):4692-4704. https://doi.org/10.1523/jneurosci.3233-16.2017

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