The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Alieva A.M.

Pirogov Russian National Research Medical University

Sozykin A.V.

Pirogov Russian National Research Medical University;
Central Clinical Hospital of the Russian Academy of Science

Lyalina V.V.

Pirogov Russian National Research Medical University

Skripnichenko E.A.

Pirogov Russian National Research Medical University

Teplova N.V.

Pirogov Russian National Research Medical University

Batov M.A.

National Medical Research Radiological Centre

Nikitin A.E.

Central Clinical Hospital of the Russian Academy of Science

Shnakhova L.M.

Sechenov First Moscow State Medical University

Izimarieva D.V.

Central Clinical Hospital of the Russian Academy of Science

Nikitin I.G.

Pirogov Russian National Research Medical University

Modern view on the problem of atherosclerosis in HIV-positive people

Authors:

Alieva A.M., Sozykin A.V., Lyalina V.V., Skripnichenko E.A., Teplova N.V., Batov M.A., Nikitin A.E., Shnakhova L.M., Izimarieva D.V., Nikitin I.G.

More about the authors

Journal: Russian Cardiology Bulletin. 2022;17(2): 25‑32

DOI: 10.17116/Cardiobulletin20221702125

Views: 3483

Downloaded: 108

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Alieva AM, Sozykin AV, Lyalina VV, et al. . Modern view on the problem of atherosclerosis in HIV-positive people. Russian Cardiology Bulletin. 2022;17(2):25‑32. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221702125

 
МСФ на ЯМ
Close metadata

HIV-associated diseases are quite diverse, and cardiovascular lesions are one of the direct causes of mortality in HIV patients. Observational studies have shown that HIV-infected individuals have a high risk of adverse cardiovascular events compared to other ones. Cardiovascular diseases caused by atherosclerosis, including myocardial infarction and stroke, are currently one of the main causes of mortality in these patients. Some authors empathized acceleration of atherogenesis following HIV infection. Possible causes are direct impact of HIV and other factors occurring in these people: side effects of antiretroviral therapy, drug abuse, HIV-related comorbidities. In addition to specific risk factors, patients with HIV infection can also have traditional ones including smoking, physical inactivity, obesity and hypercholesterolemia. The results of various studies show a huge scientific and practical interest in the problem of atherosclerosis in patients with HIV infection.

Keywords:

HIV
cardiovascular diseases
atherosclerosis
endothelial dysfunction
statins

Authors:

Alieva A.M.

Pirogov Russian National Research Medical University

Sozykin A.V.

Pirogov Russian National Research Medical University;
Central Clinical Hospital of the Russian Academy of Science

Lyalina V.V.

Pirogov Russian National Research Medical University

Skripnichenko E.A.

Pirogov Russian National Research Medical University

Teplova N.V.

Pirogov Russian National Research Medical University

Batov M.A.

National Medical Research Radiological Centre

Nikitin A.E.

Central Clinical Hospital of the Russian Academy of Science

Shnakhova L.M.

Sechenov First Moscow State Medical University

Izimarieva D.V.

Central Clinical Hospital of the Russian Academy of Science

Nikitin I.G.

Pirogov Russian National Research Medical University

Received:

26.03.2022

Accepted:

11.04.2022

List of references:

  1. Clinical guidelines “HIV infection in adults”. Developers: National Association of Specialists in the Prevention, Diagnosis and Treatment of HIV Infection. National Virological Association. [Electronic resource] 2020. (In Russ.). https://cr.minzdrav.gov.ru/recomend/79
  2. World Health Organization. HIV AIDS. 2021. [Electronic resource]. Accessed 31.01.22.  https://www.who.int/ru/news-room/fact-sheets/detail/hiv-aids
  3. Mondal P, Aljizeeri A, Small G, Malhotra S, Harikrishnan P, Affandi JS, Buechel RR, Dwivedi G, Al-Mallah MH, Jain D. Coronary artery disease in patients with human immunodeficiency virus infection. Journal of Nuclear Cardiology. 2021;28(2):510-530.  https://doi.org/10.1007/s12350-020-02280-4
  4. Goryacheva OG, Koziolova NA, Terekhina NA. HIV-associated pathology of the cardiovascular system. Russ J Cardiol. 24(11):148-154. (In Russ.). https://doi.org/10.15829/1560-4071-2019-11-148-154
  5. Durstenfeld MS, Hsue PY. Mechanisms and primary prevention of atherosclerotic cardiovascular disease among people living with HIV. Current Opinion in HIV and AIDS. 2021;16(3):177-185.  https://doi.org/10.1097/COH.0000000000000681
  6. Patel AA, Budoff MJ. Coronary Artery Disease in Patients with HIV Infection: An Update. American Journal Cardiovascular Drugs. 2021;21(4):411-417.  https://doi.org/10.1007/s40256-020-00451-9
  7. Hsue PY, Waters DD. HIV infection and coronary heart disease: mechanisms and management. Nature Reviews Cardiology. 2019;12(16):745-759.  https://doi.org/10.1038/s41569-019-0219-9
  8. Krikke M, van Lelyveld SF, Tesselaar K, Arends JE, Hoepelman IM, Visseren FL. The role of T cells in the development of cardiovascular disease in HIV-infected patients. Atherosclerosis. 2014;237(1):92-98.  https://doi.org/10.1016/j.atherosclerosis.2014.08.054
  9. Wang T, Yi R, Green LA, Chelvanambi S, Seimetz M, Clauss M. Increased cardiovascular disease risk in the HIV-positive population on ART: potential role of HIV-Nef and Tat. Cardiovascular Pathology. 2015;24(5):279-282.  https://doi.org/10.1016/j.carpath.2015.07.001
  10. Zaaqoq AM, Khasawneh FA, Smalligan RD. Cardiovascular Complications of HIV-Associated Immune Dysfunction. Cardiology Researh and Practice. 2015;2015:02638. https://doi.org/10.1155/2015/302638
  11. Hsue PY, Lo JC, Franklin A, Bolger AF, Martin JN, Deeks SG, Waters DD. Progression of Atherosclerosis as Assessed by Carotid Intima-Media Thickness in Patients with HIV Infection. Circulation. 2004;13(109):1603-1608. https://doi.org/10.1161/01.CIR.0000124480.32233.8A
  12. Ho JE, Scherzer R, Hecht FM, Maka K, Selby V, Martin JN, Ganz P, Deeks SG, Hsue PY. The association of CD4 + T-cell counts and cardiovascular risk in treated HIV disease. AIDS. 2012;9(26):1115-1120. https://doi.org/10.1097/QAD.0b013e328352ce54
  13. Lichtenstein KA, Armon C, Buchacz K, Chmiel JS, Buckner K, Tedaldi EM, Wood K, Holmberg SD, Brooks JT. Low CD4+ T Cell Count Is a Risk Factor for Cardiovascular Disease Events in the HIV Outpatient Study. Clinical Infectious Diseases. 2010;4(51):435-447.  https://doi.org/10.1086/655144
  14. Triant VA, Regan S, Lee H, Sax PE, Meigs JB, Grinspoon SK. Association of immunologic and virologic factors with myocardial infarction rates in a US healthcare system. Journal of Acquired Immune Deficiency Syndromes. 2010;5(55):615-619.  https://doi.org/10.1097/QAI.0b013e3181f4b752
  15. Hanna DB, Ramaswamy C, Kaplan RC, Kizer JR, Anastos K, Daskalakis D, Zimmerman R, Braunstein SL. Trends in Cardiovascular Disease Mortality among Persons with HIV in New York City, 2001—2012. Clinical Infectious Diseases. 2016;8(63):1122-1129. https://doi.org/10.1093/cid/ciw470
  16. Royston L, Isnard S, Lin J, Routy JP. Cytomegalovirus as an Uninvited Guest in the Response to Vaccines in People Living with HIV. Viruses. 2021;13(7):1266. https://doi.org/10.3390/v13071266
  17. Schnittman SR, Hunt PW. Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection. Current Opinion in HIV and AIDS. 2021;16(3):168-176.  https://doi.org/10.1097/COH.0000000000000678
  18. Knudsen A, Kristoffersen US, Panum I, Hansen YB, Skottrup PD, Hasbak P, Kjaer A, Lebech AM. Coronary artery calcium and intima-media thickness are associated with level of cytomegalovirus immunoglobulin G in HIV-infected patients. HIV Medicine. 2019;1(20):60-62.  https://doi.org/10.1111/hiv.12672
  19. Masiá M, Robledano C, Ortiz de la Tabla V, Antequera P, López N, Gutiérrez F. Increased Carotid Intima-Media Thickness Associated with Antibody Responses to Varicella-Zoster Virus and Cytomegalovirus in HIV-Infected Patients. PLoS ONE. 2013;5(8). https://doi.org/10.1371/journal.pone.0064327
  20. Luján JA, Rugeles MT, Taborda NA. Contribution of the Microbiota to Intestinal Homeostasis and its Role in the Pathogenesis of HIV-1 Infection. Current HIV Research. 2019;17(1):13-25.  https://doi.org/10.2174/1570162X17666190311114808
  21. Sim JH, Mukerji SS, Russo SC, Lo J. Gastrointestinal Dysfunction and HIV Comorbidities. Current HIV/AIDS Reports. 2021;18(1):57-62.  https://doi.org/10.1007/s11904-020-00537-8
  22. Borges ÁH, O’Connor JL, Phillips AN, Neaton JD, Grund B, Neuhaus J, Vjecha MJ, Calmy A, Koelsch KK, Lundgren JD. Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer during HIV Infection. Journal of Infectious Diseases. 2016; 3(214):408-416.  https://doi.org/10.1093/infdis/jiw173
  23. Head BM, Mao R, Keynan Y, Rueda ZV. Inflammatory mediators and lung abnormalities in HIV: A systematic review. PLoS One. 2019;14(12): e0226347. https://doi.org/10.1371/journal.pone.0226347
  24. Tawakol A, Ishai A, Li D, Takx RA, Hur S, Kaiser Y, Pampaloni M, Rupert A, Hsu D, Sereti I, Fromentin R, Chomont N, Ganz P, Deeks SG, Hsue PY. Association of arterial and lymph node inflammation with distinct inflammatory pathways in human immunodeficiency virus infection. JAMA Cardiology. 2017;2(2):163-171.  https://doi.org/10.1001/jamacardio.2016.4728
  25. Kelesidis T, Tran TT, Stein JH, Brown TT, Moser C, Ribaudo HJ, Dube MP, Murphy R, Yang OO, Currier JS, McComsey GA. Changes in Inflammation and Immune Activation with Atazanavir-, Raltegravir-, Darunavir-Based Initial Antiviral Therapy. Clinical Infectious Diseases. 2015;4(61):651-660.  https://doi.org/10.1093/cid/civ327
  26. Kim CJ, Rousseau R, Huibner S, Kovacs C, Benko E, Shahabi K, Kandel G, Ostrowski M, Kaul R. Impact of intensified antiretroviral therapy during early HIV infection on gut immunology and inflammatory blood biomarkers. AIDS. 2017;31(11):1529-1534. https://doi.org/10.1097/QAD.0000000000001515
  27. Toribio M, Fitch KV, Sanchez L, Burdo TH, Williams KC, Sponseller CA, McCurdy Pate M, Aberg JA, Zanni MV, Grinspoon SK. Effects of pitavastatin and pravastatin on markers of immune activation and arterial inflammation in HIV. AIDS. 2017;31(6):797-806.  https://doi.org/10.1097/QAD.0000000000001427
  28. O’Brien MP, Hunt PW, Kitch DW, Klingman K, Stein JH, Funderburg NT, Berger JS, Tebas P, Clagett B, Moisi D, Utay NS, Aweeka F, Aberg JA. Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy. Open Forum Infectious Diseases. 2017;4(1):ofw278. https://doi.org/10.1093/ofid/ofw278
  29. Tenorio AR, Zheng Y, Bosch RJ, Krishnan S, Rodriguez B, Hunt PW, Plants J, Seth A, Wilson CC, Deeks SG, Lederman MM, Landay AL. Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment. The Journal of Infectious Diseases. 2014;210(8):1248-1259. https://doi.org/10.1093/infdis/jiu254
  30. Longenecker CT, Funderburg NT, Jiang Y, Debanne S, Storer N, Labbato DE, Lederman MM, McComsey GA. Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals. HIV Medicine. 2013;14(6):385-390.  https://doi.org/10.1111/hiv.12013
  31. Kaplan RC, Sinclair E, Landay AL. T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. The Journal of Infectious Diseases. 2011;203(4):452-463.  https://doi.org/10.1093/infdis/jiq071
  32. Sinha A, Ma Y, Scherzer R, Hur S, Li D, Ganz P, Deeks SG, Hsue PY. Role of T-Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV. Journal of the American Heart Association. 2016; 5(12):e004243. https://doi.org/10.1161/JAHA.116.004243
  33. Leyes P, Cofan M, González-Cordón A, de Lazzari E, Trabal J, Domingo P, Negredo E, Vidal F, Forga MT, Gatell JM, Ros E, Martínez E. Increased cholesterol absorption rather than synthesis is involved in boosted protease inhibitor-associated hypercholesterolaemia. AIDS. 2018;32(10):1309-1316. https://doi.org/10.1097/QAD.0000000000001837
  34. Greffrath WP, du Plessis JM, Viljoen M, Cockeran M. Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation. South African Journal of HIV Medicine. 2018;19(1):766.  https://doi.org/10.4102/sajhivmed.v19i1.766
  35. Nix LM, Tien PC. Metabolic syndrome, diabetes, and cardiovascular risk in HIV. Current HIV/AIDS Reports. 2014;11(3):271-278.  https://doi.org/10.1007/s11904-014-0219-7
  36. Ciccullo A, Baldin G, Putaggio C, Di Giambenedetto S, Borghetti A. Comparative safety review of recommended, first-line single-tablet regimens in patients with HIV. Expert Opinion on Drug Safety. 2021;20(11):1317-1332. https://doi.org/10.1080/14740338.2021.1931115
  37. Shah ASV, Stelzle D, Lee KK, Beck EJ, Alam S, Clifford S, Longenecker CT, Strachan F, Bagchi S, Whiteley W, Rajagopalan S, Kottilil S, Nair H, Newby DE, McAllister DA, Mills NL. Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV: Systematic Review and Meta-Analysis. Circulation. 2018;138(11):1100-1112. https://doi.org/10.1161/CIRCULATIONAHA.117.033369
  38. Alonso A, Barnes AE, Guest JL, Shah A, Shao IY, Marconi V. HIV Infection and Incidence of Cardiovascular Diseases: An Analysis of a Large Healthcare Database. Journal of the American Heart Association. 2019;8(14):e012241. https://doi.org/10.1161/JAHA.119.012241
  39. Knudsen AD, Gelpi M, Afzal S, Ronit A, Roen A, Mocroft A, Lundgren J, Nordestgaard B, Sillesen H, Lebech AM, Køber L, Kofoed KF, Nielsen SD. Brief Report: Prevalence of Peripheral Artery Disease Is Higher in Persons Living with HIV Compared with Uninfected Controls. Journal of Acquired Immune Deficiency Syndromes. 2018;79(3):381-385.  https://doi.org/10.1097/QAI.0000000000001795
  40. Tort O, Escribà T, Egaña-Gorroño L. Cholesterol efflux responds to viral load and CD4 counts in HIV+ patients and is dampened in HIVexposed. Journal of Lipid Research. 2018;59(11):2108-2115. https://doi.org/10.1194/jlr.M088153
  41. Ozdemir S, Ozdemir E, Birlik B, Demirdal T. The Value of Carotid Intima-Media Thickness in the Detection of Atherosclerosis in HIV (+) Patients Subclinical Atherosclerosis in HIV (+). Journal of College Physicians and Surgens Pakistan. 2021;30(7):759-764.  https://doi.org/10.29271/jcpsp.2021.07.759
  42. Sharma A, Gupta N, Srivastava D. Carotid intima-media thickness, flow-mediated dilatation and proteinuria in patients of human immunodeficiency virus-positive patients: A case-control study. Journal of Family Medicine and Primary Care. 2018;7(2):362-367.  https://doi.org/10.4103/jfmpc.jfmpc_34_17
  43. Krikke M, Arends JE, Van Lelyveld S, Hoepelman A, Visseren F. Greater carotid intima media thickness at a younger age in HIV-infected patients compared with reference values for an uninfected cohort. HIV Medicine. 2017;18(4):275-283.  https://doi.org/10.1111/hiv.12428
  44. Peyracchia M, De Lio G, Montrucchio C, Omedè P, d’Ettore G, Calcagno A, Vullo V, Cerrato E, Pennacchi M, Sardella G, Manga P, GrossoMarra W, Vullo F, Fedele F, Biondi-Zoccai G, Moretti C, Vachiat A, Bonora S, Rinaldi M, Mancone M, D’Ascenzo F. Evaluation of coronary features of HIV patients presenting with ACS: The CUORE, a multicenter study. Atherosclerosis. 2018;274:218-226.  https://doi.org/10.1016/j.atherosclerosis.2018.05.001
  45. Sarfo FS, Nichols M, Agyei B, Singh A, Ennin E, Nyantakyi AD, Asibey SO, Tagge R, Gebregziabher M, Jenkins C, Ovbiagele B. Burden of subclinical carotid atherosclerosis and vascular risk factors among people living with HIV in Ghana. Journal of the Neurological Sciences. 2019;397:103-111.  https://doi.org/10.1016/j.jns.2018.12.026
  46. Chukaeva II, Komarova IV, Kravchenko AV, Kushakova TE. The role of HIV infection in the development of risk factors for cardiovascular diseases in people with a natural course of HIV infection and receiving antiretroviral therapy. Cardiosomatica. 2014;5(2):36-40. (In Russ.).
  47. Arnaiz de Las Revillas F, Gonzalez-Quintanilla V, Parra JA, Palacios E, Gonzalez-Rico C, Arminanzas C, Gutierrez-Cuadra M, Oterino A, Farinas-Alvarez C, Farinas MC.. Evaluation of endothelial function and subclinical atherosclerosis in patients with HIV infection. Scientific Reports. 2021;11(1):18431. https://doi.org/10.1038/s41598-021-97795-2
  48. Subramanya V, McKay HS, Brusca RM, Palella FJ, Kingsley LA, Witt MD, Hodis HN, Tracy RP, Post WS, Haberlen SA. Inflammatory biomarkers and subclinical carotid atherosclerosis in HIV-infected and HIV-uninfected men in the Multicenter AIDS Cohort Study. PLoS One. 2019;14(4): e0214735. https://doi.org/10.1371/journal.pone.0214735
  49. Di Yacovo S, Saumoy M, Sánchez-Quesada JL, Navarro A, Sviridov D, Javaloyas M, Vila R, Vernet A, Low H, Peñafiel J, García B, Ordoñez-Llanos J, Podzamczer D. Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study. PLoS One. 2020;15(8): e0237739. https://doi.org/10.1371/journal.pone.0237739
  50. Toribio M, Fitch KV, Stone L, Zanni MV, Lo J, de Filippi C, Sponseller CA, Lee H, Grundberg I, Thompson MA, Aberg JA, Grinspoon SK. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. EBioMedicine. 2018;35:58-66.  https://doi.org/10.1016/j.ebiom.2018.08.039
  51. De Filippi C, Christenson R, Joyce J, Park EA, Wu A, Fitch KV, Looby SE, Lu MT, Hoffmann U, Grinspoon SK, Lo J.Statin Effects on Myocardial Fibrosis Markers in People Living With HIV. Journal of Acquired Immune Deficiency Syndromes. 2018;78(1):105-510.  https://doi.org/10.1097/QAI.0000000000001644
  52. De Filippi C, Lo J, Christenson R, Grundberg I, Stone L, Zanni MV, Hang L, Grinspoon S.Novel mediators of statin effects on plaque in HIV: a proteomics approach. AIDS. 2018;32(7):867-876.  https://doi.org/10.1097/QAD.0000000000001762
  53. Dirajlal-Fargo S, Kamari V, Sattar A, Alan K, Funderburg N, Labbato D, Pirro L, Longenecker CT, Wilson WH, McComsey G. Effect of statin on arginine metabolites in treated HIV-infection. Atherosclerosis. 2017; 266:74-80.  https://doi.org/10.1016/j.atherosclerosis.2017.09.030
  54. Hussain SK, Golozar A, Widney DP, Rappocciolo G, Penugonda S, Bream JH, Martinez-Mazda O. Effect of Statin Use on Inflammation and Immune Activation Biomarkers in HIV-Infected Persons on Effective Antiretroviral Therapy. AIDS Res Hum Retroviruses. 2021;37(5):357-367.  https://doi.org/10.1089/AID.2020.0127
  55. Lee D. HIV: how to manage dyslipidaemia in HIV. Drugs Context. 2022; 11:2021-8-7.  https://doi.org/10.7573/dic.2021-8-7

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.