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Kapelko V.I.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Lakomkin V.L.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Timoshin A.A.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Rodnenkov O.V.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Zorin A.V.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Abramov A.A.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Lukoshkova E.V.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Ermishkin V.V.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Gramovich V.V.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Vyborov O.N.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Dragnev A.G.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Arzamastsev E.V.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Vanin A.F.
Semenov institute of chemical physics of the Russian academy of sciences, Moscow, Russia;
Institute for regenerative medicine, Sechenov First Moscow State Medical University, Moscow, Russia
Application of native NO-donor in cardiology
Journal: Russian Cardiology Bulletin. 2019;14(2): 26‑35
Views: 2134
Downloaded: 47
To cite this article:
Kapelko VI, Lakomkin VL, Timoshin AA, et al. . Application of native NO-donor in cardiology. Russian Cardiology Bulletin.
2019;14(2):26‑35. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20191402126
The experimental and clinical data of usage of stable nitric oxide donor, dinitrosyl iron complexes, are considered. On the basis of this compound, the drug Oxacom was created in the National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Its hypotensive effect, unlike other nitric oxide donors, was much more prolonged — up to 8—10 hours in humans due to gradual release of nitric oxide from complexes. The drug successfully passed two phases of clinical trials. Oxacom also had ability to reduce the pressure in a small circle of rats with pulmonary hypertension. The drug reduced coronary tone in the isolated rat heart, and in vivo experiments increased myocardial contractility and relaxabiity in rats with CHF. This ability makes Oxacom a promising drug for the treatment of cardiac pathologies with reduced myocardial NO-synthase activity.
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Authors:
Kapelko V.I.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Lakomkin V.L.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Timoshin A.A.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Rodnenkov O.V.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Zorin A.V.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Abramov A.A.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Lukoshkova E.V.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Ermishkin V.V.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Gramovich V.V.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Vyborov O.N.
National Cardiology Research Center, Russian Ministry of Health, 3 Cherepkovskaya 15A, Moscow, 121552, Russian Federation
Dragnev A.G.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Arzamastsev E.V.
Federal State budget organization «National medical research center of cardiology» of the Ministry of healthcare of the Russian Federation, Moscow, Russia
Vanin A.F.
Semenov institute of chemical physics of the Russian academy of sciences, Moscow, Russia;
Institute for regenerative medicine, Sechenov First Moscow State Medical University, Moscow, Russia
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