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Maksimenko A.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

Approximation of new generation pharmacological enzyme researches to clinical practice

Authors:

Maksimenko A.V.

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Journal: Russian Cardiology Bulletin. 2018;13(4): 41‑49

DOI: 10.17116/Cardiobulletin20181304141

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APPROXIMATION OF NEW GENERATION PHARMACOLOGICAL ENZYME RESEARCHES TO CLINICAL PRACTICE
APPROXIMATION OF NEW GENERATION PHARMACOLOGICAL ENZYME RESEARCHES TO CLINICAL PRACTICE

To cite this article:

Maksimenko AV. Approximation of new generation pharmacological enzyme researches to clinical practice. Russian Cardiology Bulletin. 2018;13(4):41‑49. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20181304141

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Significant widening of drug arsenal has been beetled the research and development of modified enzyme derivatives. Biomedical investigation of these means has demonstrated their high efficacy in vivo and perspective of therapeutic application. A few groups of modified biocatalyst study were formed against different injuries including cardiological disturbances. It is possible to select the research of antibody-drug derivatives, construction of multienzyme nanoensembles for extra- and intracellular action, sequential investigation of modified enzymes for founded ingoing to medical practice on the base of their targeted delivery to injury centre. The research front of mentioned above studies is fairly wide providing the possibility of success breakthrough along a few directions against different injuries due to cooperative efforts of scientific and medical coworkers.

Keywords:

enzymes
modification
targeted drug delivery
cardiological injuries
oxidative stress
nanoconjugates

Authors:

Maksimenko A.V.

Institute of the Clinical Cardiology named after A.L. Myasnikov of National Medical Research Center for Cardiology, Moscow, Russia

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References:

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