Coronary and aortic calcification in high cardiovascular risk patients with low bone mineral density

Blankova Z.N.; Samsonova N.S.; Barinova I.V.; Fedotenkov I.S.; Shariya M.A.; Ternovoy S.K.; Ageev F.T.

doi:https://doi.org/10.17116/Cardiobulletin201813123-29

Blankova Z.N.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Samsonova N.S.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Barinova I.V.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

SPIN RSCI: 6145-0926
Scopus AuthorID: 35788141500
ORCID: 0000-0003-0447-1734

Fedotenkov I.S.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Shariya M.A.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Ternovoy S.K.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Ageev F.T.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Coronary and aortic calcification in high cardiovascular risk patients with low bone mineral density

Authors:

Blankova Z.N., Samsonova N.S., Barinova I.V., Fedotenkov I.S., Shariya M.A., Ternovoy S.K., Ageev F.T.

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Journal: Russian Cardiology Bulletin. 2018;13(1): 23‑29

DOI: 10.17116/Cardiobulletin201813123-29

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To cite this article:

Blankova ZN, Samsonova NS, Barinova IV, Fedotenkov IS, Shariya MA, Ternovoy SK, Ageev FT. Coronary and aortic calcification in high cardiovascular risk patients with low bone mineral density. Russian Cardiology Bulletin. 2018;13(1):23‑29. (In Russ.)
https://doi.org/10.17116/Cardiobulletin201813123-29

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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Abstract:

Background: Osteoporosis and atherosclerosis are diseases with pathophysiological similarities. Vascular calcification has been associated inconsistently with low bone mineral density(BMD). The aim of the study was investigating the relationship of coronary artery calcification (CAC) and thoracic aortic calcification (TAC) with BMD. Material and methods: 86 high cardiovascular risk patients average age of 65 years with atherosclerosis of brachiocephalic arteries without ischemic heart disease were divided into three groups by the results of dual-energy X-ray absorptiometry (DEXA): T-score> –SD normal BMD (n=18), T-score from –1 to –2.5 SD osteopenia (n=48) and T-score ≤–2.5 SD—osteoporosis (n=20). Fasting blood analysis, 25-OH (25 (OH) D), osteoprotegerin levels, arterial stiffness (applanation tonometry for carotid-femoral pulse wave velocity (cfPWV) and volumetric sphygmography for ankle-brachial PWV(abPWV), multislice spiral computed tomography for calcium index (CI). Results. No correlation was found between the incidence and severity of CAC and TAC with the presence and BMD level. CAC and TAC were significantly more common in older patients, higher values of arterial stiffness parameters (abPWV), osteoprotegerin level (for CAC-trends, p=0.07), risk of major fractures and hip fractures (p<0.05). In the group of patients with CAC had higher values of brachial and central systolic blood pressure (SBP), central pulse BP, and in the presence of TAC revealed lower values of glomerular filtration rate. There were direct correlations of CAC CI and TAC CI with age, levels of brachial and central SBP, central SBP, abPWV, as well as the estimated risk of major fractures and hip fracture. The blood concentration of 25 (OH) D correlated with the severity of CAC (p<0.05). The level of osteoprotegerin was associated with the values of the lumbar BMD T-score (p<0.05) and of the thoracic aorta CI (p<0.05) in the general group of patients. Conclusion. the presence and severity of low BMD in patients with high cardiovascular risk were not associated with detection and severity of CAC and TAC. Factors associated with the presense and intensity of CAC and TAC were age, blood pressure level, arterial stiffness, osteoprotegerin, vitamin D, glomerular filtration rate.

Keywords:

coronary artery calcification

thoracic aorta calcification

low bone mineral density

osteoporosis

osteoprotegerin

Authors:

Blankova Z.N.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Samsonova N.S.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Barinova I.V.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

SPIN RSCI: 6145-0926
Scopus AuthorID: 35788141500
ORCID: 0000-0003-0447-1734

Fedotenkov I.S.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Shariya M.A.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Ternovoy S.K.

FGBU National medical research cardiology center of Russia, Moscow, Russia

Ageev F.T.

FGBU National medical research cardiology center of Russia, Moscow, Russia

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References:

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