Aim — the objective of the present study was to evaluate the changes in the parameters of microcirculation at different points of the leg skin after endovenous laser ablation. Material and methods. A total of 57 patients presenting with CEAP class C2—C4 chronic venous disease were examined with the use of laser Doppler flowmetry (LDF). Endovenous laser ablation was done to all the patients. The patients were divided into two groups. Those comprising the first group wore compression stockings during the postoperative period and received, in addition diosmin/hesperidine (Venarus) at a dose of 1 tablet (500 mg) two times a day for 2 months. The patients of the second group wore compression stockings in the postoperative period without additional pharmacotherapy. The parameters of microcirculation in the skin of the lower legs were investigated before and two months after the operation. The hemodynamic result of the surgical treatment was evaluated at the level of microcirculation by laser Doppler flowmetry. Results. The skin of the lower leg in the medial ankle region having no arteriovenous anastomoses exhibited the signs of the restoration of the regulatory mechanisms during the postoperative period with the activation of functional by-passes blood flow (p<0.05) that suggested the reduction of hydrodynamic pressure in the microcirculation bed (p<0.05). Simultaneously, the skin of the first toe with arteriovenous anastomoses showed a significant increase in the volume blood flow (p<0.05) and a decrease of the met-arteriole spasm. In the group of the patients treated with the use of Diosmin/hesperidine during the postoperative period the aforementioned changes in microcirculation were supplemented by a tendency toward certain decrease of the met-arteriole spasm were decreased at both points and activation of the functional by-pass blood flow (p<0.05). Conclusion. The method of laser Doppler flowmetry can be used as a non-invasive method for the evaluation of microcirculatory hemodynamics following the surgical intervention and for monitoring its outcomes. The study confirmed the presence of the skin regions on the lower legs differing in the architectonics of the microcirculatory bed and different mechanisms of recovery of the capillary blood flow during the postoperative period. The treatment with diosmin/hesperidine reduced the myogenic component of microvascular resistance at both studied points of the lower leg skin in comparison with control.