The objective of the present work was the comparative evaluation of the effectiveness and safety of hypothermia in the zone of intervention after phlebectomy with the use of the routine methods and controlled instrumental cooling. Material and methods. This comparative non-randomized study included 120 patients who had undergone combined phlebectomy under spinal anesthesia. The patients comprising the main group (n=60) were treated in the postoperative period with the use of controlled instrumental cooling of the zone of preceding intervention during 5 hours. Standard means of hypothermia (rubber or plastic bags filled with ice) were employed to treat the patients in the group of comparison (n=60). The bags were applied directly to the patient’s skin for 30 min with a 1.5 hour interval during a day. Changes of pain intensity in the zone of intervention estimated based on the visual analog scale (VAS) on days 1 and 2 after surgery were used as the criterion for the effectiveness of hypothermia. Results. The patients of the two groups were matched for age and sex; they were not significantly different in terms of clinical classes of the disease. In the evening of the day of surgical intervention, pain intensity estimated from VAS averaged 2.67±1.72 and 2.72±1.79 (р=0.448) in the patients of the main and control groups respectively. On the first postoperative day, mean pain intensity in the patients of the main group was estimated at 1.15 ± 1.3 and was significantly lower than that in the group of comparison (1.61±1.6) (fig. 2) even though the difference between the groups was insignificant (p=0.125). Conclusion. The use of controlled instrumental hypothermia for the treatment of the patients following combined phlebectomy allows to reduce pain intensity during the postoperative period.