The introduction of ideology of venous thrombosis and pulmonary embolism prophylaxis in the routine clinical practice is a most important goal in modern medicine. Material and methods. The second stage of the project «The Safety zone» involved 63 hospitals located in all regions of the Russian Federation. The data from a total of 80 797 patients were obtained. 50 396 (62.4%) of them had undergone surgical treatment and 15 458 (30.7%) had been given the therapeutic treatment. In all the cases, the risk of venous thromboembolism was estimated. Results. 14 731 (29.2%) surgical patients were referred to the low risk group, 20 207 (40.1%) ones to the moderate risk group, and 15 458 (30.7%) to the group at high risk of development of venous thromboembolism. 9509 (31.3%) therapeutic patients were referred to the group at low risk of venous thromboembolism 20 892 (68.7%) to the group at high risk of developing this condition. The expert verification demonstrated that the risk groups were correctly identified by the attending surgeons in 69.2% of the cases and in 88.8% casesby the therapists. The surgeons underestimated the risk of  development of venous thromboembolism in 22.5% of the patients and overestimated it in 8.3% cases. Specialists of non-surgical departments underestimated the risk of  development of this condition in 4.6% of the patients and overestimated it in 6.6% cases. The majority of the patients included in the study were given advice for the prevention of venous thromboembolism. Early activization of 83.5% of the patients in the postoperative period was undertaken in the surgical departments, elastic compression was recommended to 70.6% of them and medicamental prophylaxis to 69.7%. In therapeutic departments, 65.4% of the patients were given medicamental prophylaxis and 44.9% ones were treated by elastic compression of the lower extremities. Antithrombotic agents were prescribed to practically all patients at high risk of venous thromboembolism (including 98.6% of the surgical patients and 89.2% of the therapeutic patients). The overall mortality was estimated at 1.8%. Pulmonary embolism was the cause of death in 0.046% of the surgical patients and in 0.21% of the therapeutic ones. Conclusion. One of the main results of the project «The Safety zone» is the involvement of  specialist representing different medical disciplines (both surgical and therapeutic) in the practical realization of the principles of venous thromboembolism.