Aim. The objective of the present study was to analyse the results of diagnostics and treatment of the patients presenting with idiopathic deep vein thrombosis (DVT). Material and methods. A total of 193  patients presenting with idiopathic DVT at the age varying from 22 to 95 years were available for the examination. All of them underwent ultrasound angioscanning of the venous vessels in the lower extremities and pelvis at different stages of the follow-up. Laboratory diagnostics of the homeostatic system included routine coagulation tests. Fifty (25.9%%) patients with idiopathic DVT were selected for the molecular-genetic study with a view to detecting congenital thrombophilia. The results of the pharmacogenetic study were used to prescribe warfarin doses on an individual basis. However, the complexity of this method, the impossibility of its application, and the consequences of inadequate antithrombotic treatment made possible rivaroxaban therapy with the evaluation of its effectiveness based on the objective criteria in 34 patients. Open and endovascular surgical interventions were performed on 79 (41%) patients presenting with embolism-threatening DVT for the prevention of venous thromboembolic complications. Results. The antithrombotic treatment of 86 (44.6%) outpatients followed up during the period from 6 months to 1 year produced good and  satisfactory clinical results in 53 (81.5%) and  12 (18.5%) cases respectively. Conclusion. We have developed the algorithm for the application of the sequence of diagnostic and therapeutic methods and  control of the effectiveness of antithrombotic therapy in the patients presenting with DVT. The proposed approach is based on the analysis of the results of the clinical materials and relevant investigations. The study has demonstrated the effectiveness and hemorrhagic safety of the method for the patients given rivaroxaban therapy for the treatment of DVT.