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Kolbin A.S.

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
Saint Petersburg State University, Saint Petersburg, Russia

Livshits M.S.

Meditsinskiĭ fakul'tet i fakul'tet prikladnoĭ matematiki - protsessov upravleniia Sankt-Peterburgskogo gosudarstvennogo universiteta

Balykina Y.E.

Saint Petersburg State University, Saint Petersburg, Russia

Andriyashkin A.V.

Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

Kirienko A.I.

Russian National Research Medical University nabbed after N.I. Pirogov, Moscow, Russia

Clinical and economical evaluation of prevention of postoperative venous thromboembolism in a real practice

Authors:

Kolbin A.S., Livshits M.S., Balykina Y.E., Andriyashkin A.V., Zolotukhin I.A., Kirienko A.I.

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Journal: Journal of Venous Disorders. 2011;5(2): 5‑11

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Table of contents

CLINICAL AND ECONOMICAL EVALUATION OF PREVENTION OF POSTOPERATIVE VENOUS THROMBOEMBOLISM IN A REAL PRACTICE
CLINICAL AND ECONOMICAL EVALUATION OF PREVENTION OF POSTOPERATIVE VENOUS THROMBOEMBOLISM IN A REAL PRACTICE

To cite this article:

Kolbin AS, Livshits MS, Balykina YE, Andriyashkin AV, Zolotukhin IA, Kirienko AI. Clinical and economical evaluation of prevention of postoperative venous thromboembolism in a real practice. Journal of Venous Disorders. 2011;5(2):5‑11. (In Russ.)

Подписка 2025-2 (Journal of Venous Disorders)
 
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Results of clinico-economic analysis of the completed part of Safety Zone Project regarding preventive treatment with enoxaparin (ENX, 6 113 cases) and unfractionated heparin (UFH, 2944 cases) in real practice among moderate and high VTE risk groups are presented. VTE events occurred more frequently in UFH group vs ENX group (3,06% и 1,34% respectively; OR 0,43; ARR 1,79%; RRR 56,8%). Hospitalization cost of VTE cases in the UFH group was 2,36 times higher and VTE treatment in this group was 2,31 times higher vs ENX (calculated per 100 patients receiving prophylaxis). Total of the prevention costs for ENX and UFH did not differ despite the lower utilitarian cost of UFH. Cost-effectiveness ratio was slightly better for ENX (by 2,46%) and expenditures for non-effective prevention were lower than for UFH. The expertise results demonstrate economic disadvantages of changing ENX for UFH in the VTE risk group after surgery.

Keywords:

venous thromboembolism
prevention
enoxaparin
unfractionated heparin
pharmacoeconomics

Authors:

Kolbin A.S.

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia;
Saint Petersburg State University, Saint Petersburg, Russia

Livshits M.S.

Meditsinskiĭ fakul'tet i fakul'tet prikladnoĭ matematiki - protsessov upravleniia Sankt-Peterburgskogo gosudarstvennogo universiteta

Balykina Y.E.

Saint Petersburg State University, Saint Petersburg, Russia

Andriyashkin A.V.

Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

Kirienko A.I.

Russian National Research Medical University nabbed after N.I. Pirogov, Moscow, Russia

List of references:

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  2. Rossiiskie klinicheskie rekomendatsii po diagnostike, lecheniyu i profilaktike venoznykh tromboembolicheskikh oslozhnenii. Flebologiya 2010;1:2-37.
  3. Amin A.N., Lin J., Lenhart G., Schulman K.L. Clinical and economic outcomes in patients at risk of venous thromboembolism receiving appropriate enoxaparin or unfractionated heparin prophylaxis. Thromb Haemost 2009;102:2:321-326.
  4. Deitelzweig S.B., Becker R., Lin J., Benner J. Comparison of the two-year outcomes and costs of prophylaxis in medical patients at risk of venous thromboembolism. Thromb Haemost 2008;100:5:810-820.
  5. Schädlich P.K., Kentsch M., Weber M. et al. Cost effectiveness of enoxaparin as prophylaxis against venous thromboembolic complications in acutely ill medical inpatients: modelling study from the hospital perspective in Germany. Pharmacoeconomics 2006;24:6:571-591.
  6. Sistema standartizatsii v zdravookhranenii Rossiiskoi Federatsii. Otraslevoi standart kliniko-ekonomicheskogo issledovaniya. Obshchie polozheniya 91500.14.0001-2002. MZ SR RF. Prikaz ot 27 maya 2002 g.
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  9. http://www.pharmindex.ru
  10. Vardanyan A.V., Mumladze R.B., Belousov D.Yu., Roitman E.V. Kliniko-ekonomicheskii analiz profilaktiki posleoperatsionnykh venoznykh tromboembolicheskikh oslozhnenii. Kachestvennaya klinicheskaya praktika 2006;1:51-63.
  11. Gubler E.V. Vychislitel'nye metody analiza i raspoznavaniya patologicheskikh protsessov. L: Meditsina 1978;296.
  12. Fletcher R., Fletcher S., Vagner E. (red.). Klinicheskaya epidemiologiya. Osnovy dokazatel'noi meditsiny: Per. s angl. M: Media Sfera 1998;347.
  13. http://www.hutchon.net

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