Gastrointestinal stromal tumors (GIST) account for only about 1% of all tumors of the gastrointestinal tract. The most common GIST sites are the stomach and small intestine, while the esophagus is considered an extremely rare localization of this type of tumor. The rarity of GIST localization in the esophagus leads to the lack of clear recommendations for their treatment. The team of authors presents a case of successful treatment of a giant GIST of the thoracic esophagus in the volume of subtotal resection of the esophagus with simultaneous gastroplasty with a gastric flap and intrathoracic anastomosis. The article presents a clinical case of GIST. A 66-year-old woman complained of difficulty in swallowing, which she noted during the year. Endoscopic examination revealed a mass with compression of the middle and lower thoracic esophagus. According to the biopsy performed under the control of endosonography, the diagnosis of GIST of the esophagus was established. MSCT of the chest from 13.07.20 in the subbronchial part of the esophagus to the supradiaphragmatic part had a rounded formation measuring 68×60×82 mm with compression of the left atrium, inferior vena cava. On August 27, 2020, subtotal resection of the esophagus was performed with simultaneous laparoscopic gastroplasty and intrathoracic anastomosis. When isolating the right surface of the tumor, its growth to the parenchyma of the lower lobe of the right lung was revealed. The tumor was separated from the parenchyma of the right lung in an acute way within healthy tissues, the parenchyma was sutured. The tumor has been removed. Formed circular esophagogastroanastomosis end to side. With the use of indocyanine green, perfusion control of the prepared gastric graft and the formed anastomosis was performed. The postoperative period proceeded without complications. Oral nutrition was started on the 4th day after the operation. The patient was discharged for outpatient treatment on the 8th day. According to the results of immunohistochemical examination, the tumor was verified as GIST. The patient was prescribed adjuvant therapy with imatinib for 3 years. During postoperative follow-up of the patient for 1 year, according to MSCT of the chest and abdominal cavity, no signs of tumor recurrence were detected. Thus, despite the large size of a non-epithelial tumor of the esophagus and its complex relationship with the surrounding structures, it is possible to perform radical surgical treatment, including using a minimally invasive approach. The use of indocyanine green at various stages of reconstruction makes it possible to confidently assess the viability of tissues, which contributes to a safer formation of anastomosis.