Association between Helicobacter pylori infection and overlap syndrome between functional dyspepsia and irritable bowel syndrome

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OBJECTIVE

Yo assess the severity of functional dyspepsia (FD) symptoms with concomitant irritable bowel syndrome (IBS) and Helicobacter pylori (H. pylori) infection.

METHODS AND MATERIALS

We examined 27 patients with IBS who were being treated at the Gastroenterology Center. We used surveys: «7×7», the Spielberger-Hanin anxiety test, and a survey of the attitude toward the diseases. Additionally, we conducted peripheral electrogastroenterocolography and H. pylori detection using serology, rapid urease tests, or stool antigen tests.

RESULTS

We found that 44.4% of patients had overlap between FD and IBS. According to the «7×7» questionnaire, patients with both conditions reported a high level of distress, scoring 20 [15.25; 21.75] points. In contrast, those with only IBS had milder distress, scoring 11 [10; 13] points (p<0.001). Individuals with H.pylori infection reported even higher distress levels, scoring 21 [12; 22] points, while those without the infection reported moderate distress, with a score of 13 [10; 14.75] points (p=0.036). Among patients with H. pylori infection, 85.7% experienced FD symptoms, compared to 30% in patients without H. pylori infection (p=0.024). The amplitude of gastric electrical activity, gastric and duodenal rhythms in patients with both IBS and FD was greater than in patients with only IBS (p=0.03). Most patients with isolated IBS and those with both IBS and FD had a high level of anxiety (74.1%) but had a positive attitude towards their illness (63%).

CONCLUSION

Overlap between IBS and FD worsens the overall well-being of patients. H. pylori infection may play a role in exacerbating gastrointestinal symptoms in patients with functional diseases.

Keywords:

irritable bowel syndrome

functional dyspepsia

Helicobacter pylori

Authors:

Butov M.A.

Ryazan State Medical University

ORCID: 0000-0003-3402-1128

Zhestkova T.V.

Ryazan State Medical University

ORCID: 0000-0002-6505-1031

Shebbi R.

Ryazan State Medical University

ORCID: 0000-0002-9201-4578

Received:

14.11.2022

Accepted:

02.04.2023

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