Association between Helicobacter pylori infection and overlap syndrome between functional dyspepsia and irritable bowel syndrome

Butov M.A.; Zhestkova T.V.; Shebbi R.

doi:https://doi.org/10.17116/dokgastro20231204120

Butov M.A.

Ryazan State Medical University

ORCID: 0000-0003-3402-1128

Zhestkova T.V.

Ryazan State Medical University

ORCID: 0000-0002-6505-1031

Shebbi R.

Ryazan State Medical University

ORCID: 0000-0002-9201-4578

Association between Helicobacter pylori infection and overlap syndrome between functional dyspepsia and irritable bowel syndrome

Authors:

Butov M.A., Zhestkova T.V., Shebbi R.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2023;12(4): 20‑26

DOI: 10.17116/dokgastro20231204120

Read: 2200 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Butov MA, Zhestkova TV, Shebbi R. Association between Helicobacter pylori infection and overlap syndrome between functional dyspepsia and irritable bowel syndrome. Russian Journal of Evidence-Based Gastroenterology. 2023;12(4):20‑26. (In Russ.)
https://doi.org/10.17116/dokgastro20231204120

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)

Использование инфографики авторами научных работ

Close metadata

OBJECTIVE

Yo assess the severity of functional dyspepsia (FD) symptoms with concomitant irritable bowel syndrome (IBS) and Helicobacter pylori (H. pylori) infection.

METHODS AND MATERIALS

We examined 27 patients with IBS who were being treated at the Gastroenterology Center. We used surveys: «7×7», the Spielberger-Hanin anxiety test, and a survey of the attitude toward the diseases. Additionally, we conducted peripheral electrogastroenterocolography and H. pylori detection using serology, rapid urease tests, or stool antigen tests.

RESULTS

We found that 44.4% of patients had overlap between FD and IBS. According to the «7×7» questionnaire, patients with both conditions reported a high level of distress, scoring 20 [15.25; 21.75] points. In contrast, those with only IBS had milder distress, scoring 11 [10; 13] points (p<0.001). Individuals with H.pylori infection reported even higher distress levels, scoring 21 [12; 22] points, while those without the infection reported moderate distress, with a score of 13 [10; 14.75] points (p=0.036). Among patients with H. pylori infection, 85.7% experienced FD symptoms, compared to 30% in patients without H. pylori infection (p=0.024). The amplitude of gastric electrical activity, gastric and duodenal rhythms in patients with both IBS and FD was greater than in patients with only IBS (p=0.03). Most patients with isolated IBS and those with both IBS and FD had a high level of anxiety (74.1%) but had a positive attitude towards their illness (63%).

CONCLUSION

Overlap between IBS and FD worsens the overall well-being of patients. H. pylori infection may play a role in exacerbating gastrointestinal symptoms in patients with functional diseases.

Keywords:

irritable bowel syndrome

functional dyspepsia

Helicobacter pylori

Authors:

Butov M.A.

Ryazan State Medical University

ORCID: 0000-0003-3402-1128

Zhestkova T.V.

Ryazan State Medical University

ORCID: 0000-0002-6505-1031

Shebbi R.

Ryazan State Medical University

ORCID: 0000-0002-9201-4578

Received:

14.11.2022

Accepted:

02.04.2023

Close metadata

References:

Lazebnik LB, Golovanova EV, Volel BA, Korochanskaya NV, Lyalyukova EA, Mokshina MV, Mekhtiev SN, Mekhtieva OA, Metsaeva ZV, Petelin DS, Simanenkov VI, Sitkin SI, Cheremushkin SV, Chernogorova MV, Khavkin AI; Russian Scientific Medical Society of Therapists; Scientific Society of Gastroenterologists of Russia. Functional diseases of the digestive system. Crossover syndromes. Clinical guidelines. Eksperimental’naya i klinicheskaya gastroenterologiya. 2021;192(8):5-117. (In Russ.). https://doi.org/10.31146/1682-8658-ecg-192-8-5-117
Maev IV, Umyarova RM, Andreev DN, Vyuchnova ES, Lebedeva EG, Dicheva DT, Borzova DV. Overlap of functional dyspepsia and irritable bowel syndrome by revised Rome IV criteria: meta-analysis. Meditsinskiy sovet. 2021;(5):12-20. (In Russ.). https://doi.org/10.21518/2079-701X-2021-5-12-20
Barberio B, Yiannakou Y, Houghton LA, Black CJ, Savarino EV, Ford AC. Overlap of Rome IV Irritable Bowel Syndrome and Functional Dyspepsia and Effect on Natural History: A Longitudinal Follow-Up Study. Clinical Gastroenterology and Hepatology. 2022;20(2):e89-e101. https://doi.org/10.1016/j.cgh.2021.04.011
Jones MP, Shah A, Walker MM, Koloski NA, Holtmann G, Talley NJ. Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities. Neurogastroenterology and Motility. 2022;34:e14349. https://doi.org/10.1111/nmo.14349
Choi YJ, Kim N, Yoon H, Shin CM, Park YS, Kim J.-W, Kim YS, Lee DH, Jung HC. Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses. Journal of Gastroenterology and Hepatology. 2017;32:1553-1561. https://doi.org/10.1111/jgh.13756
Ivashkin VT, Maev IV, Shelygin YuA, Baranskaya EK, Belous SS, Belousova EA, Beniashvili AG, Vasilyev SV, Veselov AV, Grigoryev EG, Kostenko NV, Kashnikov VN, Kulikovskiy VF, Loranskaya ID, Lyashenko OS, Poluektova EA, Rumyantsev VG, Timerbulatov VM, Fomenko OYu, Khubezov DA, Chashkova EYu, Chibisov GI, Shapina M.V, Sheptulin AA, Shifrin OS, Trukhmanov AS, Alekseeva OP, Alekseenko SA., Baranovsky AYu., Zolnikova OYu., Korochanskaya NV, Mammayev SN, Khlynov IB, Tsukanov VV. Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia. Rossijskij zhurnal gastroenterologii, gepatologii, koloproktologii. 2021;31(5):74-95. (In Russ.). https://doi.org/10.22416/1382-4376-2021-31-5-74-95
Bordin DS, Livzan MA. The Consensus Maastricht VI Is Published: What’s New? Effektivnaya farmakoterapiya. 2022;18(22):72-84. (In Russ.). https://doi.org/10.33978/2307-3586-2022-18-22-72-84
Sheptulin AA, Storonova OA, Rumyantseva DE. Consensus Meeting of European Society of Neurogastroenterology and Motility on Functional Dyspepsia (2020): Have We Dotted All the I’s? Rossijskij zhurnal gastroenterologii, gepatologii, koloproktologii. (In Russ.). https://doi.org/10.22416/1382-4376-2021-31-2-40-45
Ivashkin VT, Sheptulin AA, Poluektova YeA, Reykhart DV, Belostotsky AV, Drozdova AA, Arnautov VS. Potential of «7×7» (7 symptoms per 7 days) questionnaire in assessment of symptom dynamics of functional dyspepsia and irritable bowel syndrome. Rossijskij zhurnal gastroenterologii, gepatologii, koloproktologii. 2016;3:24-32. (In Russ.). https://doi.org/10.22416/1382-4376-2016-26-3-24-33
Vasserman LI, Trifonova EA, Shhelkova OJu. Psihologicheskaja diagnostika i korrekcija v somaticheskoj klinike: nauchno-prakticheskoe rukovodstvo. SPb.: Rech’; 2011. (In Russ.).
Klinicheskaja psihologija: Uchebnik dlja vuzov. 5-e izd. Pod red. Karvasarskogo B.D. SPb.: Piter; 2021. (In Russ.).
Rusina NA. Psychological status and adaptive resourses patients with cancer. Rossijskij mediko-biologicheskij vestnik im. akad. I.P. Pavlova. 2012;20(3):115-121. (In Russ.). https://doi.org/10.17816/PAVLOVJ20123115-121
Butov MA, Shurpo EM, Kuznetsov PS, Dzhurzhevich MD. Normative values for peripheral electrical gastroenterocolonography. Terapevticheskii arkhiv. 2015;2:45-48. (In Russ.). https://doi.org/10.17116/terarkh201587245-48
Kim YA, Cho YJ, Kwak SG. The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis. International Journal of Environmental Research and Public Health. 2020;17(7):2524. https://doi.org/10.3390/ijerph17072524