Quality of life index in patients with achalasia after peroral endoscopic myotomy

Close metadata

OBJECTIVE

Quality of life evaluation in patients with achalasia after peroral endoscopic myotomy according to SF-36, GIQLI questionnaires, and Eckardt score.

MATERIAL AND METHODS

We performed endoscopic myotomy in 72 patients (27 men, 45 women, age range 15—72 years) between 2017 and 2021. The disease duration ranged from 6 months to 40 years. All patients were questioned using Eckardt score before intervention and after 1, 3, 6, 9 and 12 months, SF-36 and GIQLI before intervention and after 1, 3, 6 and 12 months.

RESULTS

Oral food intake was restored in all patients one month after the intervention, with positive dynamics in the main indicators of all questionnaires. A difference in Eckardt scores before and in all periods after surgery was noticed. According to the SF-36 questionnaire, 1, 3, 6 and 12 months after operation all indicators, including the physical component of health and the psychological component of health, were significantly higher than indicators before the operation. According to the GIQLI questionnaire, one month after the operation all questionnaire indicators improved and remained after 3, 6, and 12 months.

CONCLUSION

The quality of life after peroral endoscopic myotomy in patients with achalasia, according to questionnaires was improved from the first month after intervention and remained at a high level for 12 months after. Further observations are required to assess the long-term results of the intervention.

Keywords:

achalasia

peroral endoscopic myotomy

quality of life

endoscopy

surveys and questionnaires

Authors:

Drobayzgin E.A.

Novosibirsk State Medical University;
Novosibirsk State Regional Clinical Hospital;
Meshalkin National Medical Research Center

ORCID: 0000-0002-3690-1316

Chikinev Yu.V.

Novosibirsk State Medical University;
Novosibirsk State Regional Clinical Hospital

ORCID: 0000-0002-6795-6678

Mitko N.I.

Novosibirsk State Medical University

ORCID: 0000-0002-6447-637X

Received:

29.12.2021

Accepted:

22.03.2022

List of references:

Haito-Chavez Y, Inoue H, Beard KW, Draganov PV, Ujiki M, Rahden BHA, Desai PN, Pioche M, Hayee B, Haji A, Saxena P, Reavis K, Onimaru M, Balassone V, Nakamura J, Hata Y, Yang D, Pannu D, Abbas A, Perbtani YB, Patel LY, Filser J, Roman S, Rivory J, Mion F, Ponchon T, Perretta S, Wong V, Maselli R, Ngamruengphong S, Chen YI, Bukhari M, Hajiyeva G, Ismail A, Pieratti R, Kumbhari V, Galdos-Cardenas G, Repici A, Khashab MA. Comprehensive analysis of adverse events associated with per oral endoscopic myotomy in 1826 patients: an international multicenter study. American Journal of Gastroenterology. 2017;112(8):1267-1276. https://doi.org/10.1038/ajg.2017.139
Ponds FA, Fockens P, Lei A, Neuhaus H, Beyna T, Kandler J, Frieling T, Chiu PWY, Wu JCY, Wong VWY, Costamagna G, Familiari P, Kahrilas PJ, Pandolfino JE, Smout AJPM, Bredenoord AJ. Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes among Treatment-Naive Patients with Achalasia: A Randomized Clinical Trial. JAMA. 2019;322(2):134-144. https://doi.org/10.1001/jama.2019.8859
Olson MT, Triantafyllou T, Singhal S. A Decade of Investigation: Peroral Endoscopic Myotomy Versus Laparoscopic Heller Myotomy for Achalasia. Journal of Laparoendoscopic and Advanced Surgical Techniques. Part A. 2019;29(9):1093-1104. https://doi.org/10.1089/lap.2019.0242
Ward MA, Gitelis M, Patel L, Vigneswaran Y, Carbray J, Ujiki MB. Outcomes in patients with over 1-year follow-up after peroral endoscopic myotomy (POEM). Surgical Endoscopy. 2017;31(4):1550-1557. https://doi.org/10.1007/s00464-016-5130-4
Li CJ, Tan YY, Wang XH, Liu DL. Peroral endoscopic myotomy for achalasia in patients aged 65 years. World Journal of Gastroenterology. 2015;21(30):9175-9181. https://doi.org/10.3748/wjg.v21.i30.9175
Hernández Mondragón OV, González Martinez MA, Blancas Valencia JM, Hernandez Reyes ML, Solórzano Pineda OM, Blanco Velasco G. Long-term quality of life after peroral endoscopic myotomy remains compromised in patients with achalasia type III. Endoscopy. 2017;49(12):1209-1218. https://doi.org/10.1055/s-0043-117401
Perbtani YB, Mramba LK, Yang D, Suarez J, Draganov PV. Life after per-oral endoscopic myotomy: long-term outcomes of quality of life and their association with Eckardt scores. Gastrointestinal Endoscopy. 2018;87(6):1415-1420.e1. https://doi.org/10.1016/j.gie.2018.01.019
Chan SM, Wu JC, Teoh AY, Yip HC, Ng EK, Lau JY, Chiu PW. Comparison of early outcomes and quality of life after laparoscopic Heller’s cardiomyotomy to peroral endoscopic myotomy for treatment of achalasia. Digestive Endoscopy. 2016;28(1):27-32. https://doi.org/10.1111/den.12507
Liu XJ, Tan YY, Yang RQ, Duan TY, Zhou JF, Zhou XL, Liu DL. The Outcomes and Quality of Life of Patients with Achalasia after Peroral Endoscopic Myotomy in the Short-Term. Annals of Thoracic and Cardiovascular Surgery. 2015;21(6):507-512. https://doi.org/10.5761/atcs.oa.15-00066
Peng L, Tian S, Du C, Yuan Z, Guo M, Lu L. Outcome of Peroral Endoscopic Myotomy (POEM) for Treating Achalasia Compared with Laparoscopic Heller Myotomy (LHM). Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2017;27(1):60-64. https://doi.org/10.1097/SLE.0000000000000368
Ling TS, Guo HM, Yang T, Peng CY, Zou XP, Shi RH. Effectiveness of peroral endoscopic myotomy in the treatment of achalasia: a pilot trial in Chinese Han population with a minimum of one-year follow-up. Journal of Digestive Diseases. 2014;15(7):352-358. https://doi.org/10.1111/1751-2980.12153
Dacha S, Wang L, Li X, Jiang Y, Philips G, Keilin SA, Willingham FF, Cai Q. Outcomes and quality of life assessment after per oral endoscopic myotomy (POEM) performed in the endoscopy unit with trainees. Surgical Endoscopy. 2018;32(7):3046-3054. https://doi.org/10.1007/s00464-017-6015-x
Gong EJ, Na HK, Ahn JY, Jung KW, Kim DH, Choi KD, Song HJ, Jung HY. Prospective evaluation of the efficacy of peroral endoscopic myotomy in patients with achalasia. Medicine (Baltimore). 2021;100(23):e26248. https://doi.org/10.1097/MD.0000000000026248
Sharata AM, Dunst CM, Pescarus R, Shlomovitz E, Wille AJT, Reavis KM, Swanstrom LL. Peroral endoscopic myotomy (POEM) for esophageal primary motility disorders: analysis of 100 consecutive patients. Journal of Gastrointestinal Surgery. 2015;19(1):161-170. https://doi.org/10.1007/s11605-014-2610-5
Vigneswaran Y, Tanaka R, Gitelis M, Carbray J, Ujiki MB. Quality of life assessment after peroral endoscopic myotomy. Surgical Endoscopy. 2015;29(5):1198-1202. https://doi.org/10.1007/s00464-014-3793-2
Zhong C, Tan S, Ren Y, Lü M, Peng Y, Fu X, Tang X. Quality of Life Following Peroral Endoscopic Myotomy for Esophageal Achalasia: A Systematic Review and Meta-Analysis. Annals of Thoracic and Cardiovascular Surgery. 2020;26(3):113-124. https://doi.org/10.5761/atcs.ra.19-00273
Khashab MA, Sanaei O, Rivory J, Eleftheriadis N, Chiu PWY, Shiwaku H, Ogihara K, Ismail A, Abusamaan MS, El Zein MH, Wong VW, Billioux VG, Kumbhari V, Kalloo AN, Ponchon T, Pioche M. Peroral endoscopic myotomy: anterior versus posterior approach: a randomized single-blinded clinical trial. Gastrointestinal Endoscopy. 2020;91(2):288-297.e7. https://doi.org/10.1016/j.gie.2019.07.034

Close metadata